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Total antioxidant status in the blood serum of rats exposed to N-nitroso compounds and nitric oxide synthase inhibitors

100%

Grudzinski I. P., Frankiewicz-Jozko A., Szarska E.

Roczniki Państwowego Zakładu Higieny

2005

tom 56

nr 2

In this study, the total antioxidant status (TAS) was assayed in the blood serum of rats pretreated per os with either N-nitrosodiethylamine (NDEA) (0.1 mg/kg b.w./day) or N-methyl-N-nitrosourea (NMU) (0.1 mg/kg b.w./day) for 30 days. The animals were also dosed per os with spermidine (SPR) (10 mg/kg b.w./day) for a first 21 day period, and Nto-nitro-L-arginine methyl ester (L-NAME) (10 mg/kg b.w./day) given to animals for 3 days (days 22-24), respectively. Nitric oxide synthase (NOS) inhibitor, L-NAME was found to mitigate TAS levels in the blood serum of rats pretreated with NDEA and NMU. No such changes were found in animals dosed with L-NAME only nor even with L-NAME and spermidine, respectively. Since spermidine, also known as an inhibitor of iNOS synthesis, elevated TAS levels in rats dosed with L-NAME and NDEA/NMU, the polyamine was suggested to modify the NOS/NO origin to serve the physiological level of the total anti-oxidant status in rat blood serum.

Occurrence of volatile N-nitrosamines in Polish processed meat products

100%

Domanska K., Kowalski B.

Bulletin of the Veterinary Institute in Puławy

2003

tom 47

nr 2

Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG

70%

Arabski M., Kazmierczak P., Wisniewska-Jarosinska M., Morawiec Z., Morawiec-Bajda A., Klupinska G., Drzewoski J., Chojnacki J., Blasiak J.

Cellular and Molecular Biology Letters

2006

tom 11

nr 4

The pathogenesis of stomach cells can be associated with their susceptibility to exogenous dietary irritants, like nitrosamines such as dimethylnitrosamines (DMNA), and to the effects of non-dietary factors, including Helicobacter pylori infection. We used N-methyl-N'-nitro N-nitrosoguanidyne (MNNG) as a surrogate agent that induces a spectrum of DNA damage similar to DMNA. Using the alkaline comet assay, we showed that antioxidants--vitamins C and E, quercetin, and melatonin--reduced the genotoxic effect of MNNG in H. pylori-infected and non-infected human gastric mucosa cells (GMCs). To compare the sensitivity of the stomach and the blood, the experiment was also carried out in peripheral blood. We observed a higher level of DNA damage induced by MNNG in H. pylori-infected than in noninfected GMCs. We did not note any difference in the efficacy of the repair of the damage in either type of GMC. H. pylori infection may play an important role in the pathogenesis of GMCs, as it can modulate their susceptibility to dietary mutagens/carcinogens, thus contributing to gastric cancer.

Ograniczanie wyników

1 Bulletin of the Veterinary Institute in Puławy

1 Cellular and Molecular Biology Letters

1 Roczniki Państwowego Zakładu Higieny

1 Arabski M.

1 Blasiak J.

1 Chojnacki J.

1 Domanska K.

1 Drzewoski J.

1 Frankiewicz-Jozko A.

1 Grudzinski I. P.

1 Kazmierczak P.

1 Klupinska G.

1 Kowalski B.

1 Morawiec Z.

1 Morawiec-Bajda A.

1 Szarska E.

1 Wisniewska-Jarosinska M.

1 2006

1 2005

1 2003

Wyniki wyszukiwania

Total antioxidant status in the blood serum of rats exposed to N-nitroso compounds and nitric oxide synthase inhibitors

Occurrence of volatile N-nitrosamines in Polish processed meat products

Helicobacter pylori infection can modulate the susceptibility of gastric mucosa cells to MNNG