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1
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Divergent effects of bicuculline and picrotoxin on ketamine-induced apneustic breathing

100%
Budzinska K.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 4
39-46
This study tested the potential role of inhibitory neurotransmission in the mechanism of apneustic respiration evoked by ketamine, an NMDA receptors antagonist. In the experiments performed in anesthetized, paralyzed, and ventilated cats, ketamine, in a dose of 0.5 mg/kg, was administered before and after GABAA receptor blockade with picrotoxin or bicuculline; all agents were given intravenously. Ketamine elicited a transient, hourlong apneustic respiration consisting of an increase in inspiratory duration and a decrease in inspiratory neural amplitude. After prior administration of picrotoxin, but not bicuculline, the maximum apneustic-like prolongation of inspiration evoked by ketamine was considerably reduced. The results suggest that the GABA receptor subunits specifically sensitive to picrotoxin play a role in shaping the ketamine-induced apneustic breathing.
2
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Effect of pesticides kynurenic acid production in rat brain slices

100%
Zielinska E., Kocki T., Saran T., Borbely S., Kuc D., Vilagi I., Urbanska E. M., Turski W. A.
Annals of Agricultural and Environmental Medicine
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2005
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tom 12
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nr 2
177-179
Kynurenic acid (KYNA) is a broad spectrum antagonist of ionotropic glutamate receptors, preferentially active at the strychnine-insensitive glycine allosteric site of the N-methyl-D-aspartate (NMDA) receptor, and a noncompetitive antagonist of alpha7 nicotinic receptor. Animal studies showed that it possesses anticonvulsant and neuroprotective properties. Its involvement in the pathophysiology of various brain disorders was suggested. In this study, the effect of pesticides on KYNA production in brain cortical slices was investigated. Pyrethroids, deltamethrin and fenpropathrin significantly lowered KYNA production. Methomyl, bensultap, fipronil, diquat and MCPA were ineffective in this regard. In view of this data, the inhibition of KYNA synthesis appear to merit further investigation as a potential factor contributing to the toxicology of pyrethroids.
3
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Hydrogen sulfide in the nucleus tractus solitarii regulates gastric acid secretion in rats

84%
Sun H., Yang J., Shi Y., Wang Y., Li C., Zhu M.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 4
4

In vitro-evaluation of lipid emulsions as vehicles for the administration of xenon: Interaction with NMDA receptors

84%
Weigt H. U., Georgieff M., Fohr K. J., Adolph O.
Acta Neurobiologiae Experimentalis
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2009
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tom 69
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nr 2
207-216
The noble gas xenon is an antagonist of the NMDA (N-methyl-D-aspartate)-type glutamate receptor which may account for the ideal anesthetic profile and potent neuroprotective properties demonstrated even at subanesthetic concentrations. Because lipid emulsions also promote NMDA antagonistic effects they may serve as ideal carriers for xenon. In this in vitro study, we investigated the efficacy of xenon dissolved in various lipid emulsions (Intralipid®, Lipofundin®, ClinOleic® and Abbolipid®) on NMDA-evoked currents in cultured cortical neurons. The NMDA receptor blocking property at a clinically relevant concentration seen in the lipid emulsions tested may contribute to the anesthetic, analgetic and neuroprotective effects of xenon administered by way of these lipid carriers. Abbolipid® may serve as the most acceptable carrier since the NMDA antagonistic effect of xenon was enhanced in combination with this emulsion.
5

Memantine up-regulates nicotinic acetylcholine receptors expression in the cortex and sub-cortical white matter of aging rat brain

84%
Polrolniczak A., Rozycka A., Helias-Rodzewicz Z., Kempisty B., Grzelak T., Ziemnicka K., Steinborn B., Jagodzinski P. P., Dorszewska J.
Acta Neurobiologiae Experimentalis
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2013
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tom 73
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nr 1
Memantine (MEM) is a potent open channel blocker of N-methyl-Daspartate receptors (NMDARs), and primary has been developed for treatment of neuropathic pain, symptoms of dementia and AD. On the other hand, MEM is able to act as an open channel blocker on several other ligand gated ion channels, e.g., the α4β2 and α7 nicotinic acetylcholine receptors (nAChRs). The aged-related decline in the nAChRs expression could be associated with other senescence markers, such as increased oxidative stress leading to oxidative DNA changes (high level of 8-oxo-2’dG), accompanied with significant decrease in level of the OGG1 protein involved in DNA repair process. To study whether MEM treatment might influence on the α7 and α4 nAChRs expression in the aging rat brain tissues, we analyzed RNA and protein levels by RQ-PCR and Western blot validation in three brain structures: cerebral grey matter (CGM), sub-cortical white matter (SCWM) and cerebellum (Ce) of twenty one female Wistar rats. The animals were divided into following experimental groups: the first group consisted of five 3.0–3.5-month-old females, which was assigned as a young control group, and the remaining sixteen females aged of 18–24 month were divided into three following sub-groups: (1) aged control group of 5 rats; (2) a vehicle group of 5 rats which received intraperitoneal injections of deionized water (3) memantine-treated group of 6 rats. In each group, the selected brain areas have also been analyzed to determinate the levels of oxidative stress. In CGM and SCWM brain structures the level of 8-oxo-2’dG was significantly reduced in old rats after MEM administration (CGM P=0.05; SCWM P<0.05). Western blot analysis has also revealed a significant up-regulation of OGG1 level in CGM after MEM administration (CGM P=0.05). MEM specifically up-regulated mRNA level of cortical α4 subunit in the CGM region of aging rat brain (CGM, P<0.05). In the sub-cortical white matter an important increase of α7 mRNA level has been observed after MEM administration (SCWM P<0.05). The level of α7 nAChR protein was significantly up-regulated also in CGM and Ce regions of MEM treated rats (SCWM P=0.05; CGM P<0.05; Ce P<0.05). We demonstrated that processes related to aging, such as a decreases in OGG1 and nAChRs expression can be modified after memantine administration: (1) A significant increase in the CGM of α4 and α7 subunits, as well as up-regulated α7 level in the SCWM after MEM administration suggests that nAChRs play an important role in compensatory mechanisms facilitating the impaired cholinergic neurotransmission following treatment with MEM. (2) MEM significantly up-regulates cortical OGG1 protein expression and reduces the level of 8-oxo-2’dG in CGM. (3) A significant increase in both mRNA and protein levels of α7 nAChR along with reduction of 8-oxo-2’dG in SCWM, following treatment with MEM, suggests that the effect of MEM on cholinergic function may be associated with antioxidant mechanisms. Whether these protective effects of MEM are direct or are mechanistically remote from NMDARs antagonism, have to be evaluated in the further studies.
6

Causes of L-cysteine neurotoxicity

84%
Wlodek L.
Acta Biologica Cracoviensia. Series Zoologia
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2002
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tom 44
7

Effect of unilateral injection of MK-801 into the area of A10 cells on feeding evoked by stimulation of homologous area in the contralateral hemisphere

84%
Maliszewska-Scislo M., Trojniar W.
Acta Neurobiologiae Experimentalis
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2000
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tom 60
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nr 4
It was found previously that unilateral electrolytic and 6-OHDA lesions of the ventral tegmental area (VTA) and unilateral intra-VTA injection of bicuculline resulted in facilitation of behavioral responses evoked by electrical stimulation of the symmetrical VTA area in the contralateral hemisphere. We postulated that „the contralateral facilitation effect", which may reflect the yet unexplored mechanism of immediate compensation after acute unilateral brain injury, is attributable to the A10 DA neurons and their regulatory inputs. The present study was aimed at examining the possible involvement of NMDA-mediated glutamatergic transmission in VTA in the „contralateral facilitation effect". The behavioral model of the VTA stimulation-induced feeding in rats was used. Latency to eat was measured as a function of stimulation frequency before and after unilateral intra-VTA injection of non-competitive NMDA receptors antagonist, MK-801, (doses 0.0, 1.25 and 2.5 p,g). MK-801 caused a dose-dependent augmentation of feeding evoked by stimulation of the contralateral VTA, which manifested as a decrease in the reaction frequency threshold and a leftward shift of the latency/frequency curve. Dose 2.5 replicated the facilitatory effect of electrolytic and 6-OHDA lesions. The results are interpreted in terms of MK-801-evoked depression of excitatory glutamatergic tone over A10 DA cells and compensatory increase in DA release in the contralateral hemisphere.
8

Bicuculline, AP-7 and behavioral activity in rats

67%
Car H., Kuziemka-Leska M., Wisniewski K.
Acta Neurobiologiae Experimentalis
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1998
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tom 58
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nr 2
9

The effects of MK-801 and U-83836E on post-ischemic reperfusion injury in rat brain

67%
Durmaz R., Inal M., Angin K., Atasoy M. A., Altinisik M., Tel E.
Acta Neurobiologiae Experimentalis
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1999
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tom 59
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nr 2
10

The effect of glutamate uptake inhibitors on hippocampal evoked potentials in vitro

67%
El-Sherif Y., Singh N., Khan T., Wieraszko A.
Acta Neurobiologiae Experimentalis
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1999
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tom 59
|
nr 2
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