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Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants

100%

Strzelecka M., Bzowska M., Koziel J., Szuba B., Dubiel O., Rivera Nunez D., Heinrich M., Bereta J.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

139-156

It is believed that bioactive compounds from plant foods may have health beneficial effects and reduce the risk of chronic inflammatory diseases. In this study extracts of 121 plants typical for the traditional Mediterranean diet have been screened for their potential anti-inflammatory activities. The ability of the extracts to inhibit cytokinestimulated, iNOS-dependent synthesis of nitric oxide in murine endothelial cells, without affecting cell viability, was the primary indicator of their anti-inflammatory properties. Based on these experiments we selected eight plant extracts for further analysis: Chrysanthemum coronarium L., Scandix pecten-veneris L., Urospermum picroides (L.) Scop. Ex F. W. Smith, Amaranthus cf. graecizans L., Onopordum macracanthum Schousboe, Eryngium campestre L., Artemisia alba Turra and Merendera pyrenaica (Pourret) Fourn. Only the effects of Onopordum macracanthum could be non-specific since the extract strongly inhibited total protein synthesis. All remaining 7 extracts decreased nitric oxide and TNFa synthesis in the cells of monocyte origin activated with LPS, and 4 of them significantly reduced surface expression of VCAM1 on TNFa-stimulated endothelial cells. All seven plant extracts decreased cytokine or LPS-stimulated iNOS mRNA levels in both cell types. Further research to identify bioactive compounds influencing intracellular signaling pathways activated by cytokines and LPS will consequently be needed in order to better understand these in vitro effects.

2

Antioxidant properties of Mediterranean food plant extracts: geographical differences

100%

Schaffer S., Schmitt-Schillig S., Muller W. E., Eckert G. P.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

115-124

Locally grown, wild food plants seasonally contribute a considerable portion of the daily diet in certain Mediterranean areas and it has been suggested that the beneficial effects of the Mediterranean diet on human health partly originate from the antioxidant effect of flavonoid-rich food plants. The nutrient content of most wild plants is higher than that of cultivated ones and may vary depending on the prevailing environmental conditions. Accordingly, three local Mediterranean plant foods (i.e. Cichorium intybus, Sonchus oleraceus, Papaver rhoeas) were collected in Greece (Crete), southern Italy, and southern Spain in order to assess possible differences in their in vitro antioxidant potential. The biological assays revealed diverse intra-plant specific antioxidant effects for the tested extracts ranging from no activity to almost complete protection. Furthermore, substantial differences in the polyphenol content were found for the nutritionally used part of the same plant originating from different locations. However, no clear correlations between the polyphenol content and the extracts' antioxidant activities were found. Taken together, the data suggest that certain local Mediterranean plant foods possess promising antioxidant activity and that the observed biological effects are possibly influenced by the geographically-dependent environmental conditions prevailing during plant growth.

3

The hidden Mediterranean diet: wild vegetables traditionally gathered and consumed in the Gargano area, Apulia, SE Italy

84%

Biscotti N., Pieroni A.

Acta Societatis Botanicorum Poloniae

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2015

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tom 84

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nr 3

Despite the extensive bio-scientific literature concerning the Mediterranean diet, which emerged in the last three decades, systematic ethnography-centered investigations on a crucial portion of this food system, linked to the traditional consumption of non-cultivated vegetables, are still largely lacking in many areas of the Mediterranean Basin. In this research, an ethnobotanical field study focusing on wild vegetables traditionally gathered and consumed locally, was conducted in a few centers and villages located in the Gargano area, northern Apulia, SE Italy, by interviewing twenty-five elderly informants. The folk culinary uses of seventy-nine botanical taxa of wild vascular plants, belonging to nineteen families, were recorded, thus showing a remarkable resilience of traditional environmental knowledge (TEK) related to wild food plants. In particular, approximately one-fourth of the recorded wild vegetables are still very commonly gathered and consumed nowadays, while ten taxa have never been reported in previous ethnobotanical studies conducted in Southern Italy. These findings demonstrate the crucial cultural role played by folk cuisines in preserving TEK, despite significant socio-economic changes that have affected the study area during the past four decades.

4

Is there any relationship between the type of alcoholic beverage and oral cancer? Focus on red wine in an European perspective

84%

Iriti M., Varoni E. M.

Polish Journal of Food and Nutrition Sciences

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2015

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tom 65

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nr 1

Since decades, it has been suggested that regular, low to moderate consumption of red wine, a major component of Mediterranean diet, at main meals, may contribute to explain the healthy properties attributed to this traditional dietary style. Despite preclinical in vitro/in vivo data have shown many signifi cant pharmacological activities of grape phytochemicals, mostly polyphenols, evidence in humans is still debated. This lack of consensus may be due to the equilibrium between the two main components of wine relevant for health: alcohol and phytochemicals. Because ethanol is a major risk factor in oral carcinogenesis, in this commentary, we briefl y discuss the relationship between the type of alcoholic beverage and oral cancer in European countries.

5

"Local food - nutraceuticals": An example of a multidisciplinary research project on local knowledge

84%

Heinrich M., Leonti M., Nebel S., Peschel W.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

5-22

Currently, dietary patterns change rapidly all over the world. Most notably, there is a fast increase in the convenience food market. Here we discuss the overall theoretical framework and strategy of an EU-funded project on local food, a common resource in many parts of the Mediterranean. Such food is often only available seasonally and is consumed either fresh (e.g. spring salads and vegetables, fruits in autumn) or in a conserved form (dried, fermented, pickled). There is an urgent need to document and analyse such local resources, which are today at the brink of disappearance. In this project, selected species were studied using a multidisciplinary approach, including strategies and methods from pharmacology, nutritional sciences and anthropology (i.e. ethnopharmacological or ethnonutritional ones). For example, all extracts were profiled using HPLC-MS, by determining their polyphenol content and using a variety of in vitro anti-oxidant assays (incl. guaiacol oxidation, xanthine oxidase inhibition, HOCl scavenging, eNOS activity). Such research also points to ways for ascertaining the intergenerational transmission of the knowledge and for sustainable development and management. Examples from field studies in southern Italy and from pharmacological studies using a variety of targets are used to illustrate the potential of such neglected resources. The wider implications of such an approach, for example, for the study of similar traditions in Central and Eastern Europe are also discussed.

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Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants

84%

Stalinska K., Guzdek A., Rokicki M., Koj A.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

157-169

During the inflammatory response at least 2 transcription factors, NF-kB and AP-1, are involved in the altered profile of gene expression. We used human hepatoma (HepG2) and human umbilical vein endothelial cells (HUVEC) as a model system: NF-kB and AP-1 were activated by the proinflammatory cytokine IL-1 in the absence or presence of 21 selected plant extracts and the effect was evaluated by the electrophoretic mobility shift assay (EMSA). In both types of cells activation of NFkB by IL-1 was significantly inhibited by extracts from Scandix australis and Artemisia alba, whereas extracts from Amaranthus sp., Eryngium campestre, Thymus pulegioides and Reichardia picroides elicited cell-type dependent response. The IL-1-induced AP-1 activation was diminished by extracts from Scandix australis, Amaranthus sp. and Artemisia alba more potently in HUVEC, while extracts from Urospermum picroides and Scandix pecten-veneris in HepG2 cells. Inhibitory activities of plant extracts towards cytokine activated NF-kB and AP-1 depend to some extent on the order of addition of IL-1 and plant extract to the cell culture, but the mechanism of action of extract components is not clear: although plant polyphenols may participate they are unlikely to be the only mediators, and MAP kinases were found generally not involved in down-regulation of transcription factors activity by plant extracts.

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The effect of a Mediterranean diet model on serum beta-carotene concentration. A preliminary assessment

84%

Witkowska A., Zujko M. E., Mironczuk-Chodakowska I.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

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nr 2

Background. Some of the main nutritional reasons for recommending a Mediterranean diet is to prevent metabolic diseases arising through free radical formation. A key constituent compound is β-carotene which, amongst the carotenoids, displays the greatest provitamin A activity as well as possessing significant antioxidant properties. Objectives. Principally, to determine the relationship between serum β-carotene levels and the effect of Mediterranean diet guidelines in a selected group of women. Materials and Methods. The subject group consisted of 26 women aged 19-22 years. A nutritional assessment was performed using 3 day repeats of 24-hour recall interviews. A 9-point aMED (alternate Mediterranean Diet) score was used to study dietary habits. Serum β-carotene was measured by liquid chromatography with photodiode array detection (HPLC-PDA). Results. β-carotene dietary intake was highly variable, ranging from 734 to 14476 μg/day (median 3022 μg/day). Serum β-carotene concentration ranged between 0.071-1.905 μmol/L (median 0.519 μmol/L) and was significantly associated with the Mediterranean Diet model (Spearman r=0.633, p<0.001). Out of the dietary sources of β-carotene, consuming carrots had the most significant impact on its serum concentration. Other dietary factors positively affecting serum β-carotene were: consumption of nuts and seeds, pulses, a favourable ratio of mono-unsaturated fatty acids to saturated fatty acids and eating fruit and wholegrain cereal products. Conclusions. Adopting a Mediterranean-based diet had a positive effect on increasing serum beta-carotene levels.

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Prevention of diet related diseases in rural population

84%

Szponar L., Rychlik E., Respondek W.

Annals of Agricultural and Environmental Medicine

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1995

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tom 02

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nr 2

9

Najlepsze na placu Pigalle

67%

Kolanowski W.

Przegląd Gastronomiczny

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2001

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tom 54

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nr 02

17

10

Mozliwosc wykorzystania zasad diety srodziemnomorskiej w polskiej racji pokarmowej

67%

Gronowska-Senger A., Smolenska M.

Roczniki Państwowego Zakładu Higieny

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2005

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tom 56

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nr 1

35-47

Podjęto próbę opracowania racji pokarmowej wykorzystującej zasady diety śródziemnomorskiej, stosując produkty i potrawy polskie. Stwierdzono możliwość stworzenia takiej racji pod warunkiem zmian w strukturze konsumpcji, tj. zwiększenia udziału produktów roślinnych kosztem zwierzęcych.

11

Mediterranean diet adherence among cosmetology students

67%

Jeziorek M., Szypowska A., Regulska-Ilol B.

Roczniki Państwowego Zakładu Higieny

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2021

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tom 72

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nr 3

12

Prevention of diseases related to unsatisfactory health quality of food and inadequate nutrition and trends in the development of agriculture and food processing in Poland

59%

Szponar L., Sekula W., Niedzialek Z., Respondek W.

Żywienie Człowieka i Metabolizm. Suplement

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1996

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tom 23

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nr 1

Ograniczanie wyników

Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants

Antioxidant properties of Mediterranean food plant extracts: geographical differences

The hidden Mediterranean diet: wild vegetables traditionally gathered and consumed in the Gargano area, Apulia, SE Italy

Is there any relationship between the type of alcoholic beverage and oral cancer? Focus on red wine in an European perspective

"Local food - nutraceuticals": An example of a multidisciplinary research project on local knowledge

Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants

The effect of a Mediterranean diet model on serum beta-carotene concentration. A preliminary assessment

Prevention of diet related diseases in rural population

Najlepsze na placu Pigalle

Mozliwosc wykorzystania zasad diety srodziemnomorskiej w polskiej racji pokarmowej

Mediterranean diet adherence among cosmetology students

Prevention of diseases related to unsatisfactory health quality of food and inadequate nutrition and trends in the development of agriculture and food processing in Poland