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1

Activity of N-lutidinylarylcarboxamides against Leishmania donovani and L.braziliensis

100%
Le P. P., Abdala H., Pagniez F., Robert J. M., Le Baut G.
Acta Parasitologica
|
1999
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tom 44
|
nr 3
Three arylcarboxamides issued from 2-amino- 4,6-dimethylpyridine, benzamide 1, furan-2-carboxamide 2 and 5-bromofuran-2-carboxamide 3 were evaluated against Leishmania promastigotes, at three doses, 0.5, 5, and 50 µM. Although benzamide 1 exerted but a moderate inhibition against cultured extracellular promastigotes at a concentration of 50 µM, furan-2-carboxamides 2 and 3 had potent activity at the same concentration. The IC₅₀ of 2 against L. donovani and L. braziliensis were 29.9 and 28.3 µM and those of 3 were 25.9 and 36.6 µM, respectively. In a BALB/c mice model of visceral leishmaniosis, an intraperitoneal administration of 10 mg/kg of 2, for 5 days, led to a consistent parasite burden reduction in the spleen smears (75.8 ± 5.7%) and in the microdilution spleen cultures (72.1 ± 0.6%). A very significant correlation (r = 0.96) was found between the two methods of spleen parasite burden quantification. These amides also exhibit potent antiinflammatory activity and it was previously stated that they inhibit arachidonic acid production by interfering in the PLA₂ activation. This suggests fact that they could disrupt Leishmania membrane lipid integrity by protein kinase C inhibition.
2
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Rownoczesne zarazenie makrofagow przez Leishmania donovani i wirus HIV-1

86%
Branska B., Lucinska A., Galary E.
Wiadomości Parazytologiczne
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1998
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tom 44
|
nr 4
647-651
The observation that hypophosphoglycan (LPG) from Leishmania donovani can lead to TNF-alfa mediated induction ofHIV-1 expression supports the idea that these protozoan parasites can be envisaged as putative cofactors in the pathogenesis of HIV-1 infection.
3
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Immunosuppression during Leishmania donovani infection: a potential target for the development of therapy

86%
Flora R., Aghazadeh-Dibavar S., Bandyopadhyay M., Dasgupta S.
Annals of Parasitology
|
2014
|
tom 60
|
nr 4
Dysfunction of T-helper 1 mediated immune responses is a hallmark of the progression of visceral leishmaniosis (VL). Several factors such as altered antigen presentation, and abnormalities in MHC/HLA, antigen processing, and T cell receptor recognition regulate the onset of immunosuppression. Recent investigations on VL patients suggest that susceptibility to visceral leishmaniosis is genetically determined and varies between populations in different geographical locations. Emerging evidence also indicates the importance of the role played by myeloid derived suppressor cells in progressive VL. This study provides a mechanistic view of means to target the signaling mechanisms of immunosuppression to determine potential therapeutic interventions.
4

Comparison between immuno-clinicopathological features of experimental and human visceral leishmaniasis by Leishmania donovani

86%
Saini S., Dube A., Sahasrabuddhe A. A., Thakur C. P., Joshi S., Rawat K., Rai A. K.
Acta Parasitologica
|
2020
|
tom 65
|
nr 1
5

Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite

86%
Sindhu K. J., Kureel A. K., Saini S., Kumari S., Verma P., Rai A. K.
Acta Parasitologica
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2018
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tom 63
|
nr 1
6

Characterization of transplasma membrane electron transport chain in wild and drug-resistant Leishmania donovani promastigote and amastigote

86%
Debnath D., Hossain M. A., Das M., Kabir A., Ibrahim M., Amin M. N., Chowdhury A., Pervin R.
Acta Parasitologica
|
2019
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tom 64
|
nr 4
7

Generation of adenosine tri-phosphate in Leishmania donovani amastigote forms

86%
Mondal S., Roy J. J., Bera T.
Acta Parasitologica
|
2014
|
tom 59
|
nr 1
Leishmania, the causative agent of various forms of leishmaniasis, is the significant cause of morbidity and mortality. Regarding energy metabolism, which is an essential factor for the survival, parasites adapt to the environment under low oxygen tension in the host using metabolic systems which are very different from that of the host mammals. We carried out the study of susceptibilities to different inhibitors of mitochondrial electron transport chain and studies on substrate level phosphorylation in wild-type L. donovani. The amastigote forms of L. donovani are independent on oxidative phosphorylation for ATP production. Indeed, its cell growth was not inhibited by excess oligomycin and dicyclohexylcarbodiimide, which are the most specific inhibitors of the mitochondrial Fo/F1-ATP synthase. In contrast, mitochondrial complex I inhibitor rotenone and complex III inhibitor antimycin A inhibited amastigote cell growth, suggesting the role of complex I and complex III in cell survival. Complex II appeared to have no role in cell survival. To further investigate the site of ATP production, we studied the substrate level phosphorylation, which was involved in the synthesis of ATP. Succinate-pyruvate couple showed the highest substrate level phosphorylation in amastigotes whereas NADH-fumarate and NADH-pyruvate couples failed to produce ATP. In contrast, NADPH-fumarate showed the highest rate of ATP formation in promastigotes. Therefore, we can conclude that substrate level phosphorylation is essential for the survival of amastigote forms of Leishmania donovani.
8

Increased level of soluble adenosine deaminase in bone marrow of visceral leishmaniasis patients: an inverse relation with parasite load

72%
Rai A. K., Kumar P., Saini S., Thakur C. P., Seth T., Dipendra D. K.
Acta Parasitologica
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2016
|
tom 61
|
nr 3
9

In vitro effects of purine and pyrimidine analogues on Leishmania donovani and Leishmania infantum promastigotes and intracellular amastigotes

72%
Azzouz S., Lawton P.
Acta Parasitologica
|
2017
|
tom 62
|
nr 3
10

A comprehensive review of cutaneous leishmaniasis in Sri Lanka and identification of existing knowledge gaps

72%
Amarasinghe A., Wickramasinghe S.
Acta Parasitologica
|
2020
|
tom 65
|
nr 2
11

An investigation of CRK protein kinases of Leishmania and the assessment of their potential as drug targets

72%
Ali N. O., Ibrahim M. E., Aradaib I. E., Grant K. M., Mottram J. C.
Cellular and Molecular Biology Letters
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2003
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tom 08
|
nr 2A
12

Intravenous treatment of Leishmania donovani infected mice with liposomal hexadecylphosphocholine

72%
Kaufmann-Kolle P., Kuhlencord A., Eibl H.
Cellular and Molecular Biology Letters
|
1996
|
tom 01
|
nr 4
Visceral leishmaniasis is a protozoan born disease, which when left untreated, leads to morbidity and mortality in humans. It was demonstrated that orally applied non-liposomal hexadecylphosphocholine exhibits remarkable therapeutic efficacy against leishmanial infections in BALB/c mice. With the added benefit that liposomal hexadecylphosphocholine is better tolerated after oral application and can be repeatedly injected intravenously without causing thrombophlebitis, we show that liposomal hexadecylphosphocholine is much more effective against visceral leishmaniasis than therapy with conventional drugs such as Pentostam®. Most important, the i.v. treatment of infected mice with liposomal hexadecylphosphocholine was the only therapy that was curative.
13

Phylogenic analysis of Chinese Leishmania isolates based on small subunit ribosomal RNA (SSU rRNA) and 7 spliced leader RNA (7SL RNA)

58%
Guan W., Cao D.-P., Sun K., Xu J.-N., Zhang J.-R., Chen D.-L., Chen J.-P.
Acta Parasitologica
|
2012
|
tom 57
|
nr 2
The leishmaniases are zoonotic diseases caused by protozoan parasites of the genus Leishmania. Leishmaniases are still endemic in China, especially in the west and northwest froniter regions. To revalue the preliminary phylogenetic results of Chinese Leishmania isolates, we amplified partial fragment of small subunit ribosomal RNA (SSU rRNA) and 7 spliced leader RNA (7SL RNA), then tested the phylogenetic relationships among Chinese Leishmania isolates and their relatives by analyzing SSU rRNA gene sequences and 7SL RNA gene sequences. 19 SSU RNA sequences and 9 7SL RNA sequences were obtained in our study, then analyzed with 42 SSU RNA sequences and 32 7SL RNA sequences retrieved from Genbank, respectively. In the Bayesian analysis of the SSU RNA gene, the isolate MHOM/CN/93/GS7 and the isolate IPHL/CN/77/XJ771 are members of Leishmania donovani complex, while the isolate MHOM/CN/84/JS1 clustered with Leishmania tropica. The other 11 Chinese Leishmania isolates (MHOM/CN/90/WC, MCAN/CN/90/SC11, MHOM/CN/80/XJ801, MHOM/CN/85/GS4, MHOM/CN/84/SD1, MCAN/CN/86/SC7, MHOM/CN/54/#3, MHOM/CN/83/GS2, MHOM/CN/90/SC10H2, MHOM/CN/89/GS6 and MHOM/CN/ 89/GS5) form an unclassified group, defined as Leishmania sp., and the most relative species to this group is L. tarentolae. In the Bayesian analysis of the 7SL RNA gene, 9 Chinese Leishmania isolates also formed an unclassified group with L. tarentolae, including canine isolate 10, MHOM/CN/85/GS4, MHOM/CN/84/SD1, MCAN/CN/86/SC7, MHOM/CN/54/#3, MHOM/ CN/83/GS2, MHOM/CN/90/SC10H2, MHOM/CN/89/GS6 and MHOM/CN/89/GS5. We concluded that: (1) Chinese Leishmania isolates are non-monophyly group; (2) an unclassified group may exist in China, and the most relative species to this group is L. tarentolae; (3) MHOM/CN/84/JS1, which was previously assigned as L. donovani, was most genetically related to L. tropica strain MHOM/SU/74/K27.
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