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The effect of Ivermectin on the number of cells and the percentage of IgA⁺ cells in bronchial (BLN) and mesenteric (MLN) lymph nodes of rats infected with 3000 L3 of Nippostrongylus brasiliensis was examined. Rats were treated subcutaneously with a dose of 100 pg/kg, 24 h after infection. After treatment, the worm burden was reduced by 90.7% in the parenteral phase and by 98.4% in the enteral phase of the infection. The respiratory tract was still occupied by the fourth stage larvae on day 6 after infection (AI). Adult worms were present in the intestine on day 18 AI while in untreated rats the infection was over already on day 13. No susceptibility to Ivermectin was found in some L4 stage of N. brasiliensis. Larvae trapped in the lungs stimulated very high level of cellular infiltration and IgA⁺ cell proliferation in the BLN. A weak enteral phase, which occurred after treatment with Ivermectin, induced a weak IgA response in the MLN. A temporary effect of Ivermectin which reduced the number of cells in MLN and no effect on the percentage of IgA⁺ cells in the BLN and MLN, were observed.
Aspects of human infection with Onchocerca volvulus was investigated in 9 villages in Okigwe LGA of Imo State, Nigeria between January 2010 and December 2011. The objectives were to compare the prevalence of different manifestations of Onchocerciasis according to gender and age, with view to determine if there had been a change in prevalence of Onchocerciasis among residents of some communities in Okigwe Local Government Area of Imo State. A cross sectional survey method was adopted for the study, blood free skin snips were collected from randomly selected consenting adults aged 5-62 years. Palpation for mobile subcutaneous lumps and clinical manifestation were observed among 960 persons comprising 511 males and 449 females. The commonest lesions observed were poor vision 17 %, nodules 15 %, leopard skin 20 %, lizard skin 15 %, and hanging groin 3 %. Musculo-skeletal pain (MSP) was recorded as one of the major complaints by 30 % of the subjects. The result showed that Onchocerciasis clinical manifestations are still prevalent, however nodules prevalence reduced among the sampled population (69.8 %).
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