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Effect of polymorphism in IGF-1 gene on production traits in Polish Holstein-Friesian cattle

100%

Siadkowska E., Zwierzchowski L., Oprzadek J., Strzalkowska N., Bagnicka E., Krzyzewski J.

Animal Science Papers and Reports

2006

tom 24

nr 3

Circulating concentrations of insulin like growth factor-1 in female dogs with spontaneous mammary tumours

84%

Szczubial M., Dabrowski R., Lopuszynski W., Bochniarz M., Krawczyk M., Urban-Chmiel R.

Medycyna Weterynaryjna

2018

tom 74

nr 03

The aim of this study was the investigation of the circulating concentration of IGF-1 in female dogs with spontaneous mammary tumours. The study was performed on 34 female dogs undergoing surgery due to spontaneously occurring mammary gland tumours (24 malignant and 10 benign) and 10 clinically healthy female dogs. The serum concentrations of IGF-1 were determined by specific ELISA Kit assay. The mean concentrations of IGF-1 were significantly higher (P < 0.05) both in dogs with malignant (173.35 ± 120.45 ng/ml) and benign (130.58 ± 59.0 ng/ml) mammary tumours than in healthy controls (117.45 ± 71.0 ng/ml). In the group of female dogs with mammary carcinomas, the mean concentration of IGF-1 gradually increased from 132.85 ± 65.64 ng/ml in dogs with grade 1 tumours to 317.74 ± 119.25 ng/ml in those with grade 3 tumours, and significant differences (P < 0.05) were found among dogs with various grade tumours. These findings suggest that circulating IGF-1 may play an important role in the pathogenesis of canine mammary tumour. Moreover, high IGF-1 levels may reflect tumour cell differentiation into a more aggressive phenotype.

Associations between the microsatellite DNA sequence in the IGF1 gene, polymorphism in the ESR gene and selected reproduction traits in F1 [Zlotnicka Spotted x Polish Large White] sows

67%

Korwin-Kossakowska A., Sender G., Kuryl J.

Animal Science Papers and Reports

2004

tom 22

nr 2

In 53 F1 sows (Zlotnicka Spotted boars × Polish Large White sows) the insulin-like growth factor 1 (IGF1) and estrogen receptor (ESR) genes were assessed as candidate genes for total number of piglets born (TNB), number of piglets born alive (NBA), litter weight at birth (LWB), litter weight at weaning (LWW), number of piglets weaned (NPW), average piglet weight at weaning (AWW) and gestation length (GL). The IGF1 locus genotype (microsatellite sequence) was found to affect (P≤0.01) the TNB, NBA and GL when based on analysis of sows with all litters born. No association between reproductive traits and ESR genotype was found in any restrictive site. However,interesting appeared the results of the analysis including an interaction between ESR genotypem in three polymorphic sites where almost all traits investigated appeared associated (P≤0.05) with ESR genotype. However, due to the limited number of animals, conclusions on the relationship between gene polymor-phisms and reproduction traits must be considered as preliminary, and thus treated with care.

Ograniczanie wyników

2 Animal Science Papers and Reports

1 Medycyna Weterynaryjna

1 Bagnicka E.

1 Bochniarz M.

1 Dabrowski R.

1 Korwin-Kossakowska A.

1 Krawczyk M.

1 Krzyzewski J.

1 Kuryl J.

1 Lopuszynski W.

1 Oprzadek J.

1 Sender G.

1 Siadkowska E.

1 Strzalkowska N.

1 Szczubial M.

1 Urban-Chmiel R.

1 Zwierzchowski L.

1 2018

1 2006

1 2004

Wyniki wyszukiwania

Effect of polymorphism in IGF-1 gene on production traits in Polish Holstein-Friesian cattle

Circulating concentrations of insulin like growth factor-1 in female dogs with spontaneous mammary tumours

Associations between the microsatellite DNA sequence in the IGF1 gene, polymorphism in the ESR gene and selected reproduction traits in F1 [Zlotnicka Spotted x Polish Large White] sows