The authors treated 15 students (Asia, Africa) infected with Hymenolepis nana, using a single dose of praziquantel Biltricid of 30 mg/kg b.w., administered as two portions 15 mg/kg b.w. each, with an interval of 6 hrs. After two months the parasites were found to be absent in 13 persons (86.7%). The tolerance for Biltricid was found to be good, though an ultimate answer to the question of its medical application requires further studies.
Alterations in the genetic apparatus of mice bone marrow cells and testicles caused by Hymenolepis nana, Ascaris suum and Toxocara canis metabolites have been investigated by means of micronuclear test application. The activity of spermatogenesis has been investigated at experimental hymenolepidosis, migrating ascariasis and toxocarosis with the use of ³H-timidine. Helminths metabolites have been established to exert a mutagenie effect on somatic cells of bone marrow, spermatogonies and also on the generative cells (spermatides) of helminths in invaded mice. The concurrent increase in micronucleus number in erythrocytes, spermatogonies and in spermatides (to a lesser degree) of invaded mice has been revealed. The decrease in spermatogenesis activity has been established in experimental hymenolepidosis, migrating ascariasis and toxocarosis in invaded mice.