Ograniczanie wyników

Czasopisma help

  1. 8 Acta Parasitologica

  2. 5 Archivum Immunologiae et Therapiae Experimentalis

  3. 3 Bulletin of the Veterinary Institute in Puławy

  4. 2 Acta Biochimica Polonica

  5. 1 Cellular and Molecular Biology Letters

Więcej...
Autorzy help

  1. 3 Wedrychowicz H.

  2. 2 Cao S.

  3. 2 Gora-Sochacka A.

  4. 2 Li C.

  5. 2 Li X.

Więcej...
Lata help

  1. 1 2020

  2. 2 2019

  3. 2 2018

  4. 1 2016

  5. 1 2015

Więcej...
Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 21

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  DNA vaccine
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Antibody response to DNA vaccine against H5N1 avian influenza virus in broilers immunized according to three schedules

100%
Stachyra A., Gora-Sochacka A., Zagorski-Ostoja W., Krol E., Sirko A.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
2

Antigenic epitope analysis and efficacy evaluation of GRA41 DNA vaccine Against T. gondii infection

100%
Zhou J., Li C., Luo Y., Wang L.
Acta Parasitologica
|
2019
|
tom 64
|
nr 3
3

DNA vaccines against influenza

100%
Stachyra A., Gora-Sochacka A., Sirko A.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 3
4

Optimization of immunization procedure for Eimeria tenella DNA vaccine pVAX1-pEtK2-IL-2 and its stability

100%
Zhang B., Yuan C., Song X., Xu L., Yan R., Shah M. A. A., Guo C., Zhu S., Li X.
Acta Parasitologica
|
2019
|
tom 64
|
nr 4
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Construction and immunogenic properties of DNA vaccine against canine parvovirus infection

100%
Mizak B., Rzezutka A., Krol J., Kazula A.
Bulletin of the Veterinary Institute in Puławy
|
2001
|
tom 45
|
nr 2
The presented studies were concentrated on construction of the recombinant mammalian expression vector - pSecTag2B, carrying canine parvovirus VP2 gene and its N-terminal fragment. Evaluation of safety of experimental vaccines was done on laboratory animals and immunogenic properties were tested on dogs. CPV specific antibodies were not detected by HI test in serum samples collected from dogs vaccinated with recombinant plasmid pSecTag2B-CPV582. The presence of CPV specific antibodies (80-320 by HI) was confirmed 10 days after vaccination in all dogs vaccinated with pSecTag2B-CPV1774. The highest titre was obtained in sera collected from dogs vaccinated with 200 μg and 300 μg of DNA. Fourteen days after revaccination, the level of antibodies increased up to 160 in dogs vaccinated with 100 μg of DNA and up to 640 in puppies vaccinated with 200 μg and 300 μg of DNA. The antibodies were detected for at least 16 weeks. Results of the studies demonstrated the immunogenic properties of elaborated DNA vaccine.
6

DNA vaccines: are they still just a powerful tool for the future?

100%
Belakova J., Horynova M., Krupka M., Weigl E., Raska M.
Archivum Immunologiae et Therapiae Experimentalis
|
2007
|
tom 55
|
nr 6
7
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

DNA vaccines: pre-clinical efficacy and immune responses

100%
Liu M. A., Ulmer J., Shiver J., McClements W., Donnelly J.
Bulletin of the Veterinary Institute in Puławy
|
1998
|
tom 42
|
nr 1
8

Immune responses in rats and sheep induced by a DNA vaccine containing the phosphoglycerate kinase gene of Fasciola hepatica and liver fluke infection

84%
Wesolowska A., Zawistowska-Deniziak A., Norbury L. J., Wilkowski P., Januszkiewicz K., Pyziel A. M., Zygner W., Wedrychowicz H.
Acta Parasitologica
|
2016
|
tom 61
|
nr 2
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Application of DNA vaccines in fish

84%
Lepa A., Siwicki A. K., Terech-Majewska E.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 1
213-215
Vaccination is a most cost-effective way of controlling infectious diseases in fish. However, some vaccination techniques when applied to hatchery conditions are not as effective as we expect them to be. Modern molecular biology techniques offer a number of opportunities for improving existing bacterial or viral vaccines or creating new ones. One of the most promising trends in vaccinology is development of DNA vaccination. DNA vaccines are based on the gene encoding specific antigen, which is expressed in vaccinated organism and induces the host immune system. DNA vaccines, compared to conventional vaccines, have many advantages including ability to trigger wider immune response, bigger stability and possibility of large-scale production. To date, there are several reports indicating effectiveness of DNA vaccines used against fish pathogens.
10

DNA vaccine encoding Haemonchus contortus Actin induces partial protection in Goats

84%
Yan R., Wang J., Xu L., Song X., Li X.
Acta Parasitologica
|
2014
|
tom 59
|
nr 4
Actin is a globular multi-functional protein that forms microfilaments, and participates in many important cellular processes. Previous study found that Haemonchus contortus actin could be recognized by the serum of goats infected with the homology parasite. This indicated that H. contortus actin could be a potential candidate for vaccine. In this study, DNA vaccine encoding H. contortus actin was tested for protection against experimental H. contortus infections in goats. Fifteen goats were allocated into three trial groups. The animals of Actin group were vaccinated with the DNA vaccine on day 0 and 14, and challenged with 5000 infective H. contortus third stage larval (L3) on day 28. An unvaccinated positive control group was challenged with L3 at the same time. An unvaccinated negative control group was not challenged with L3. The results showed that DNA vaccine were transcribed at local injection sites and expressed in vivo post immunizations respectively. For goats in Actin vaccinated group, higher levels of serum IgG, serum IgA and mucosal IgA were produced, the percentages of CD4+ T lymphocytes, CD8+ T lymphocytes and B lymphocytes and the concentrations of TGF-β were increased significantly (P<0.05). Following L3 challenge, the mean eggs per gram feces (EPG) and worm burdens of Actin group were reduced by 34.4% and 33.1%, respectively. This study suggest that recombinant H. contortus Actin DNA vaccine induced partial immune response and has protective potential against goat haemonchosis.
11

Comparative assessment of induced immune responses following intramuscular immunization with fusion and cocktail of LeIF, LACK and TSA genes against cutaneous leishmaniasis in BALB/c mice

84%
Maspi N., Ghaffarifar F., Sharifi Z., Dalimi A., Dayer M. S.
Archivum Immunologiae et Therapiae Experimentalis
|
2018
|
tom 66
|
nr 1
12

Evaluation of the protective effect of a prime-boost strategy with plasmid DNA followed by recombinant adenovirus expressing BmAMA1 as vaccines against Babesia microti infection in hamster

84%
Wang G., Yu L., Efstratiou A., Moumouni P. F. A., Liu M., Guo H., Gao Y., Cao S., Zhou M., Li J., Ringo A. E., Xuan X.
Acta Parasitologica
|
2018
|
tom 63
|
nr 2
13

Prime-boost vaccination with plasmid DNA followed by recombinant vaccinia virus expressing BgGARP induced a partial protective immunity to inhibit Babesia gibsoni proliferation in dogs

84%
Cao S., Mousa A. A., Aboge G. O., Kamyingkird K., Zhou M., Moumouni P. F. A., Terkawi M. A., Masatani T., Nishikawa Y., Suzuki H., Fukumoto S., Xuan X.
Acta Parasitologica
|
2013
|
tom 58
|
nr 4
A heterologous prime-boost vaccination regime with DNA and recombinant vaccinia virus (rvv) vectors expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we describe the effectiveness of the prime-boost strategy by immunizing dogs with a recombinant plasmid followed by vaccinia virus, both of which expressed the glutamic acid-rich protein (BgGARP) of Babesia gibsoni. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibodies against BgGARP when compared with the control groups. The antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. Two weeks after the booster immunization with a recombinant vaccinia virus expressing BgGARP, the dogs were challenged with B. gibsoni parasite. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia. These results indicated that this type of DNA/rvv prime-boost immunization approach may have use against B. gibsoni infection in dogs.
14

Antiparasitic DNA vaccines in 21st century

84%
Wedrychowicz H.
Acta Parasitologica
|
2015
|
tom 60
|
nr 2
15

Schistosoma japonicum: the design and experimental evaluation of a multivalent DNA vaccine

84%
Li C., Yu L., Liu Z., Zhu L., Hu Y., Zhu M., Zhu X., Shi Y., Meng S.
Cellular and Molecular Biology Letters
|
2006
|
tom 11
|
nr 4
The aim of this study was to construct and evaluate the immunity efficacy of the DNA multivalent vaccine pVIVO2SjFABP-23. The vaccine was constructed and produced as follows. Forty BALB/c mice were divided into four groups designated pVIVO2, pVIVO2Sj23, pVIVO2SjFABP and pVIVO2SjFABP-23. Each mouse was immunized with 100 µg of the corresponding plasmid DNA by intramuscular injection. 28 days postvaccination, the mice were challenged with S. japonicum cercariae, and the worm and egg burdens were determined 42 days post-challenge. Serum samples were collected from all the mice before and after vaccination and at the end of the experiment, and used for antibody detection. The IFN-γ and IL-4 levels were quantified in the supernatants of specifically stimulated spleen cells. The number of worms was reduced by 52%, 40% and 42% in mice respectively immunized with pVIVO2SjFABP-23, pVIVO2Sj23 or pVIVO2SjFABP. A respective 61%, 38% and 39% egg reduction was determined relative to those mice that only received the empty pVIVO2 plasmid. pVIVO2SjFABP-23 immunization increased IgG levels against SWAP and SEA. Increased IFN-γ levels were detected in the supernatant of specific stimulated spleen cells from mice immunized with the 3 different constructs. The multivalent DNA vaccine developed induced higher levels of protection than the two monovalent tested vaccines.
16

Current status and future perspectives of DNA vaccine delivery by attenuated intracellular bacteria

84%
Dietrich G.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 3
17
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Evaluation of the DNA vaccine against classical swine fever with a special consideration of the phenotypic analysis of blood leucocytes

84%
Markowska-Daniel I., Pejsak Z.
Bulletin of the Veterinary Institute in Puławy
|
2000
|
tom 44
|
nr 2
The aim of the study was the evaluation of DNA vaccine against CSF and the estimation of its safety, protection value and immunogenicity. Piglets were vaccinated with the gene encoding the gp55 glycoprotein of CSFV with signal sequence and without the transmembrane region. For comparison the whole gene of gp55 glycoprotein and the DNA of plasmid vector only were used. For the challenge virulent Washington strain of CSFV was used. Clinical observations, body temperature and the immune response (haematological and FACS analyses, presence of virus-specific antibodies) were monitored. The presence of the virus antigen in blood, nasal swabs and organs of dead animals was checked by virus isolation, antigen ELISA and PCR methods. Only pigs vaccinated with the first construct were protected from the challenge, however, two-day fever > 40°C was registered. In other groups typical clinical and pathological symptoms accompanied by significant leukopenia were evidenced.
18

Progress in development of vaccines against most important gastrointestinal helminth parasites of humans and animals

84%
Wedrychowicz H., Wisniewski M.
Acta Parasitologica
|
2003
|
tom 48
|
nr 4
Among many vaccine approaches developed against gastrointestinal helminths in the recent years, parenteral vaccination and use of recombinant helminth antigens expressed in various expression systems have been a major focus. Significant progress has been made towards cloning of protective worm antigens. The recombinant proteins have several benefits over classic vaccine technologies, including increased safety, economy, stability and versatility. Moreover, the identification of site and developmental stage of the parasite in which the expression of genes encoding for potential vaccine antigen become possible using a variety of molecular techniques including hybridization in situ, expressed sequence tags analysis or cDNA microarray technology. Unfortunately, in the research reported so far little attention has been paid to oral vaccination, which may be of particular importance for the development of protective immunity against enteric parasites. The biggest obstacles to vaccine production at present time are: lack of an efficient expression system, which could guarantee proper post-translational modifications of recombinant helminth antigens as well as lack of efficient mucosal delivery systems. These obstacles will be possibly successfully overcome by use of transgenic plants both for the antigen expression and as adjuvants.
19

Prostate cancer and immunoproteome: awakening and reprogramming the Guardian Angels

67%
Farooqi A. A., Fayyaz S., Qureshi M. Z., Rashid S.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 3
20

DNA tumor vaccines

67%
Wlazlo A. P., Ertl H. C. J.
Archivum Immunologiae et Therapiae Experimentalis
|
2001
|
tom 49
|
nr 1
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.