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1

The DGAT1 polymorphism and breeding value of Holstein sires

100%
Citek J., Panicke L., Rehout V., Blahova B., Pavkova J.
Animal Science Papers and Reports. Supplement
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2004
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tom 22
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nr 2
2

The effects of polymorphisms in DGAT1, GH and GHR genes on reproduction and production traits in Jersey cows

84%
Komisarek J., Michalak A., Walendowska A.
Animal Science Papers and Reports
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2011
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tom 29
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nr 1
The aim of the study was to examine the impact of four single nucleotide polymorphisms in DGAT1, GH and GHR genes on reproduction, production and udder health in Jersey cattle. The study was conducted on 209 cows from the Polish active dairy population and genotypes were identified using the PCR-RFLP technique. The significant effects on certain of analysed traits were revealed of GHL127V and GHR-F279Y polymorphisms. Replacement of the phenylalanine encoding T allele by the tyrosine encoding A variant at GHR-F279Y locus led to decrease in milk, fat and protein yields. The GH-L127V-CC genotype was found to be significantly associated with the shorter calving interval and shorter interval from calving to conception than the other two GH genotypes. No relations were found between DGAT1-K232A mutation and health or reproductive traits of cows.
3

Condition of sows during reproductive activity depending on lipid metabolism gene (DGAT1) polymorphism

84%
Szyndler-Nedza M., Piorkowska K., Ropka-Molik K.
Annals of Animal Science
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2017
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tom 17
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nr 3
4

A relationship between DGAT1 K232A polymorphism and selected reproductive traits in Polish Holstein-Friesian cattle

84%
Komisarek J., Michalak A.
Animal Science Papers and Reports
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2008
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tom 26
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nr 2
The aim of the study was to analyse the relationship between DGAT1 K232A polymorphism and bulls’ breeding value for five reproductive traits – age at first insemination, calving-to-conception interval, calving-to-first service interval, non-return rate in heifers, and non-return rate in cows.The investigation was conducted on 264 Polish Black-and-White (Polish Holstein-Friesian) bulls from the active dairy population. DGAT1 genotypes were identified using the PCR-RFLP technique.The K and A allele frequencies were 0.38 and 0.62, respectively. Homozygotes AA were characterized by highest breeding values of non-return rates, both in heifers and in cows. On the contrary, for the age at first insemination and for calving-to-conception and calving-to-first service intervals, the most favourable seemed to be the KK genotype. However, the significant effect of AA (P≤0.01) was obtained only for non-return rate in cows.
5

Effects of DGAT1 variants on milk production traits in Jersey cattle

84%
Komisarek J., Waskowicz K., Michalak A., Dorynek Z.
Animal Science Papers and Reports
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2004
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tom 22
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nr 3
The aim of the study was to analyse the K232A polymorphism in the acyl CoA:diacylglycerol acyltransferase gene (DGAT1) and to estimate the effects of lysine (K) and alanine (A) encoding variants on milk yield and composition in cattle. A total of 100 Jersey cows was tested for DGAT1 genotypes using the PCR-RFLP technique. The K and A allele frequencies were 0.83 and 0.17, respectively.Effect of the K232A polymorphism on most considered traits was observed. The lysine encoding variant was associated with the high milk fat yield as well as fat and protein contents, whereas the alanine allele was related to the increased milk yield. The most significant result was obtained for the fat content of milk. None of the dominance effects proved to be significantly different from zero,that indicates the additive effect of the gene.
6

An effect of the DGAT1 gene polymorphism on breeding value of Polish Holstein-Friesian sires

84%
Nowacka-Woszuk J., Noskowiak A., Strabel T., Jankowski T., Switonski M.
Animal Science Papers and Reports
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2008
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tom 26
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nr 1
The effect of the GC→AA polymorphism in the DGAT1 gene causing amino acid substitution (łysinę – K to alanine – A) was estimated on the breeding value (BV) of 89 Polish Holstein-Friesian sires. A fragment of 411 bp of the DGAT1 gene was analysed by RFLP (Cfr1) or MSSCP (screening for other substitutions). Only GC→AA in exon 8 dinucleotide substitution was identified causing K232A amino acid substitution. The frequencies of K and A alleles were 0.54 and 0.46, respectively. The KK genotype (compared to AA and KA) was found associated with higher BV for fat and protein content of milk and lower BV for milk and protein yields. Distribution of the polymorphism within the Holstein-Friesian population, as well as its effect on bull BV are discussed.
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