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5',8-cyclo-2'-deoxyadenosine [cdA] formation by gamma-radiation. Theoretical quantum mechanics study

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Karwowski B. T., Grand A., Cadet J.

Acta Biochimica Polonica

2009

tom 56

nr 4

655-662

Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5',8-cyclonucleosides. It appears that the prerequisite for the formation of 5',8-cyclo-2'-deoxyadenosine (cdA) is the adoption of O4'-exo conformation by 2-deoxyribose; however, this is the least energetically favored conformer among the different puckered forms adopted by the furanose ring. The O4'-exo conformation was found to be present in each of the discussed mechanisms.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Cadet J.

1 Grand A.

1 Karwowski B. T.

1 2009

Wyniki wyszukiwania

5',8-cyclo-2'-deoxyadenosine [cdA] formation by gamma-radiation. Theoretical quantum mechanics study