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1

Stability of 2-chloro-2'-deoxyadenosine at various pH and temperature

100%
Tarasiuk A., Skierski J., Kazimierczuk Z.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
2

An unexpected effect of 2-chloro-2'deoxyadenosine on DNA synthesis in EHEB cells

88%
Cardoen S., Bontemps F., Van Den Neste E., Van Den Berghe G.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
3

Treatment of hairy cell leukemia patients with 2-chloro-2'-deoxyadenosine [2-CdA]

75%
Komarnicki M., Kazmierczak M., Hansz J.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
4

Substrate specificity of methylthioadenosine phosphorylase from human liver

75%
Fabianowska-Majewska K., Duley J., Fairbanks L., Simmonds A., Wasiak T.
Acta Biochimica Polonica
|
1994
|
tom 41
|
nr 4
Methylthioadenosine (MTA) phosphorylase purified 615-fold from human liver cleaved phosphorolytically nucleoside analogues at the decreasing specific activity: 5'-deoxyadenosine > 5'-iodo-5'-deoxyadenosine > MTA > adenosine > 2-chloro- adenosine > 2-chloro-5'-0-methyl-2'-deoxyadenosine > 2-chloro-2'-deoxyadenosine > > 2'-deoxyadenosine. Adenosine and analogues of 5'-deoxyadenosine were strong competitive inhibitors of MTA phosphorolysis catalysed by the human liver enzyme.
5

Discovery, mechanism and expected clinical significance of selective cytotoxicity of 2-chloro-2'-deoxyadenosine [2-CdA]

75%
Grieb P.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
6

2-chloro-2'-deoxyadenosine - clinical, biochemical and pharmacokinetic considerations

75%
Liliemark J., Juliusson G.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
7

Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2'-deoxyadenosine

75%
Bontemps F., Delacauw A., Cardoen S., Van Den Neste E., Van Den Berghe G.
Cellular and Molecular Biology Letters
|
1999
|
tom 04
|
nr 3
8

Apoptotic death of lymphocytes upon treatment with 2-chloro-2'-deoxyadenosine [2-CdA]

75%
Lassota P., Kazimierczuk Z., Darzynkiewicz Z.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
9

Systemic administration of 2-chloro-2'-deoxyadenosine [2-CdA] in patients with systemic scleroderma

63%
Majewski S., Skopinska M., Blaszczyk M., Ryba M., Grieb P., Chorzelski T., Jablonska S.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
10

Influence of 2-chloro-2'-deoxyadenosine alone and in combination with cyclophosphamide or methotrexate on murine leukemia L1210

63%
Gora-Tybor J., Robak T., Warzocha K., Grieb P.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
11

In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers

63%
Kryczka T., Bero M., Kasperczyk J., Dobrzynski P., Marciniec B., Popielarz-Brzezinska M., Grieb P.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire obser­vation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indi­cated.
12

2-chloro-2'-deoxyadenosine [2-CdA] treatment in a patient with Waldenstrom's macroglobulinaemia complicated by severe neutrocytopenia

63%
Zaucha J. M., Ciesielski D., Grieb P., Hellmann A.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
13

Antiviral activity of 2-chloro-2'-deoxyadenosine [2-CdA]

63%
Zahorska R., Mazur N., Skierski J. S., Grieb P.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
|
tom 44
|
nr 2-3
14

Template-directed base pairing of 2-chloro-2'-deoxyadenosine catalyzed by AMV reverse transcriptase

63%
Bukowska-Maciejewska A. M., Kusmierek J. T.
Acta Biochimica Polonica
|
1998
|
tom 45
|
nr 2
2-Chloro-2'-deoxyadenine (2CldA) is used for treatment of several lymphoid malignancies. Since this drug is incorporated into DNA, we have undertaken studies on base pairing of 2-chloroadenine (2ClA). 2CldA phosphoramidite was synthesized and used for preparation of 25-mer templates with 2ClA located at site 21 from the 3'-end. Kinetic parameters (Km and Vmax) for the incorporation of deoxynucleoside-5'-triphosphates by AMV reverse transcriptase opposite the 2ClA template, as well as for the extension of 2ClA·T pair, were determined. The efficiency (Vmax/Km) of incorporation of dGTP, dCTP, and dATP opposite 2ClA is at least one order of magnitude lower than opposite unmodified A. The efficiency of incorporation of dTTP opposite 2ClA is about 30-fold lower than opposite A and extension of 2ClA·T pair is 3-fold lower than of A·T pair. From the analysis of the parameters of dTTP incorporation we conclude that formation of 2ClA·T pair is thermodynamically, but not kinetically controlled. The difference in binding energy (ΔΔG) between 2ClA·T and A·T pairs in the environment of the polymerase active site is 2 kcal/mol. Our results indicate that the presence of 2ClA in DNA slows down replication, but does not lead to base-substitution mutations.
15

2-chloro-2'-deoxyadenosine [2-CdA] combined with cyclosporine A successfully prevents rejection of fetal brain stem allograft in rabbits

63%
Grieb P., Ryba M., Janczewski W., Sawicki J., Jagielski J., Andrychowski J.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
16

Cladribine [2-chloro-2'-deoxyadenosine]: new perspectives in clinical immunosuppression

63%
Gorski A., Grieb P.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
17

Treatment of patients with hairy cell leukemia with 2-chloro-2'-deoxyadenosine [2-CdA]

63%
Robak T., Krykowski E., Blasinska-Morawiec M., Urbanska-Rys H.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
18

Modulation of lymphocyte-fibroblast interactions by 2-chloro-2'-deoxyadenosine [2-CdA] in subarachnoid hemorrhage

63%
Ryba M., Grieb P., Majewski S., Makiela B., Pastuszko M., Andrychowski J., Bojarski P.
Archivum Immunologiae et Therapiae Experimentalis
|
1994
|
tom 42
|
nr 1
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