Wyniki wyszukiwania

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Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis

100%

Krajewska J. B., Pietruszka P., Tomczyk D., Chen C., Owczarek A., Karolewicz B., Czapor-Irzabek H., Gorniak A., Fichna J.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 2

2

Exploring novel colon-targeting antihistaminic prodrug for colitis

100%

Dhaneshwar S., Gautam H.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 4

3

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis of rats through the induction of pregnane X receptors and/or P-glycoproteins

100%

Sehirli A. O., Cetinel S., Ozkan N., Selman S., Tetik S., Yuksel M., Dulger F. G. A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 2

4

Conformational destabilization of Bacillus licheniformis alpha-amylase induced by lysine modification and calcium depletion

80%

Tan C. Y., Raja Abdul Rahman R. N. Z. B., Kadir H. A., Tayyab S.

Acta Biochimica Polonica

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2011

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tom 58

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nr 3

Bacillus licheniformis α-amylase (BLA) was chemically modified using 100-fold molar excess of succinic anhydride over protein or 0.66 M potassium cyanate to obtain 42 % succinylated and 81 % carbamylated BLAs. Size and charge homogeneity of modified preparations was established by Sephacryl S-200 HR gel chromatography and polyacrylamide gel electrophoresis. Conformational alteration in these preparations was evident by the larger Stokes radii (3.40 nm for carbamylated and 3.34 nm for succinylated BLAs) compared to 2.43 nm obtained for native BLA. Urea denaturation results using mean residue ellipticity (MRE) as a probe also showed conformational destabilization based on the early start of transition as well as ΔGDH2O values obtained for both modified derivatives and Ca-depleted BLA. Decrease in ΔGDH2O value from 5,930 cal/mol (for native BLA) to 3,957 cal/mol (for succinylated BLA), 3,336 cal/mol (for carbamylated BLA) and 3,430 cal/mol for Ca-depleted BLA suggested reduced conformational stability upon modification of amino groups of BLA or depletion of calcium. Since both succinylation and carbamylation reactions abolish the positive charge on amino groups (both α- and ε- amino), the decrease in conformational stability can be ascribed to the disruption of salt bridges present in the protein which might have released the intrinsic calcium from its binding site.

5

A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats

80%

Toklu H. Z., Kabasakal L., Imeryuz N., Kan B., Celikel C., Cetinel S., Orun O., Yuksel M., Dulger G. A.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 4

6

Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats

80%

Matsunami M., Kirishi S., Okui T., Kawabata A.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 1

Ograniczanie wyników

Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis

Exploring novel colon-targeting antihistaminic prodrug for colitis

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis of rats through the induction of pregnane X receptors and/or P-glycoproteins

Conformational destabilization of Bacillus licheniformis alpha-amylase induced by lysine modification and calcium depletion

A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats

Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats