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The aim of this study was to evaluate the cardiovascular response to the activation of arterial chemoreceptors during voluntary apnea in snoring subjects. Fifty five men were enrolled in the study: 33 snorers and 22 non-snorers (control group). The majority of snorers were overweight and hypertensive. The experimental session consisted of 20 voluntary inspiratory apneas interspersed with 1 min free breathing periods, and 20 min recovery. The following parameters were recorded noninvasively: blood pressure, ECG, and arterial oxygen saturation. Data analysis was based on the Smietanowski procedure, written in the 4-th generation script language of MATLAB environment, which allows assessing the relative contribution of cardiac and vascular components to blood pressure variability. The results indicate that repetitive apneas led to significantly greater increases in blood pressure in the snorers. In this group, the domination of vascular influences during apnea periods reached 67 ±2.0%, which was greater than the 56 ±1.8% in the non-snorers (P<0.01). In contrast, the contribution of the cardiac component in the blood pressure response to apnea was greater in the non-snorers: 33 ±3% vs. 20 ±2% in the snorers (P<0.01). We conclude that activation of carotid chemoreceptors during voluntary apnea evokes a greater cardiovascular response in snorers, related to the reflex increase in total peripheral vascular resistance, and, consequently, a greater increase in blood pressure.
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Effects of training on the ventilatory response to hypoxia

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The purpose of the present study was to examine the influence of systematical training on the ventilatory response to hypoxia. A rebreathing technique - progressive isocapnic hypoxia - was used to measure hypoxic chemoreflex reactivity. The ventilatory response was measured in a group of 22 world class adult kayakers (22.6 ±1.9 yr), 16 young kayakers (17.8 ±1.1 yr), and 38 control subjects (21.9 ±1.9 yr). The ventilatory response to hypoxia - analyzed as the relationship (slope) MV/SaO2 (minute ventilation/oxygen arterial blood saturation) - in the adult kayakers was significantly lower (-1.03 ±0.28 L/min/%, P<0.01) compared with those in the control group (-1.81 ±0.54 L/min/%) and the young kayakers (-1.54 ±0.6 L/min/%; the difference between the latter two was insignificant). The following values of P0.1/SaO2 (mouth occlusion pressure/oxygen arterial blood saturation) relationship were found for the investigated groups: adult kayakers (-0.20 ±0.1 cmH2O/%, P<0.05), young kayakers (-0.47 ±0.1 cmH2O/%, N.S.), control group (-0.48 ±0.18 cm H2O/%). Correlation between the hypoxic ventilatory response and VO2max was significant in both groups of kayakers. These findings indicate that tolerance for hypoxia was elevated in the group of athletes compared with the control group. Hypoxic tolerance correlates with the duration of training.
Several lines of evidence suggest that physical exercise not only influences the development of muscles, cardiovascular and respiratory systems, but also exerts a significant influence on the central nervous system. We examined the influence of strength and endurance training on cognitive performance in 33 healthy elderly volunteers (women, mean age 63.5 ±4.5 yr) over a 3-month period of supervised training program. A control group consisted of 8 age-matched (mean age 66.3 ±4.6) healthy volunteers who did not participate in any exercise training program. To evaluate the cognitive performance in our subjects we used two tests: face/name association test and Stroop test. The tests were applied shortly before and immediately after the training program. In the experimental group, a significant improvement in the association test performance, on average, from 71.6 ±7.3% to 79.7 ±7.2% (P<0.0001) was observed over the 3-month training period. There were no changes in the Stroop test results over the same time. Likewise, there were no changes in the control groups. Our data demonstrate that the training regime that is strictly followed over a relatively short period of time may improve the performance in associative memory tasks in elderly subjects. The study supports the notion that physical exercise influences cognitive performance and extend this notion to be valid for healthy elderly subjects.
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The majority of hemodialyzed patients suffer from sleep disturbances. In the present study the prelevence of sleep apnea syndrome in hemodialyzed patients with end-stage renal disease (ESRD-patients) was investigated by the survey, Epworth Sleepiness Scale (ESS), and polysomnography (PSG). Sixty-one patients: 24 women and 37 men were involved in the study. All subjects participated in the first part of the study consisting of the survey and ESS. The second and third parts consisted of nighttime PSG, performed the night after hemodialysis (17 patients) and between hemodialyses (11 patients). Eleven out of the 61 patients had the symptoms of sleep apnea and heavy daily sleepiness. Eleven subjects were involved in the double PSG study: after and between hemodialyses. Obstrucive sleep apnea was found in 7 of those patients during both nights analyzed. Our results confirm the occurrence of sleep disorders in ESRD-patients. Hemodialysis does not change the prevalence of obstructive sleep apnea in chronic renal disease.
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