Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-[Z]-dehydrophenylalanine

100%

Siodlak D., Broda M. A., Rzeszotarska B., Koziol A. E., Dybala I.

Acta Biochimica Polonica

2001

tom 48

nr 4

Conformational preferences of Ac-ΔAla-NMe2 and Ac-(Z)-ΔPhe-NMe2 were studied and compared with those of their monomethyl counterparts as well as with those of their saturated analogues. X-Ray data and energy calculations revealed a highly conservative conformation of the dehydro dimethylamides, which is located in a high-energy region of the Ramachandran map.

Conformational investigation of alpha,beta-dehydropeptides. XIII. Conformational properties of N-acetyl-alpha,beta-dehydrovaline N',N'-dimethylamide

100%

Siodlak D., Rzeszotarska B., Broda M. A., Koziol A. E., Kolodziejczyk E.

Acta Biochimica Polonica

2004

tom 51

nr 1

The crystal structure of Ac-ΔVal-NMe2 (ΔVal = a,β-dehydrovaline) was determined by X-ray crystallography. The found angles φ = -60o and Ψ = 125° correspond exactly to the respective values of the (i + 1)th residue in idealised yS-turn II/VIa. Ab initio/DFT studies revealed that the molecule adopts the angle Ψ restricted only to about |130° | and very readily attains the angle φ about -50°. This is in line with its solid-state conformation. Taken together, these data suggest that the ΔVal residue combined with a C-terminal tertiary amide is a good candidate at the (i + 1)th position in a type II/VIa β-turn.

Ograniczanie wyników

2 Acta Biochimica Polonica

2 Broda M. A.

2 Koziol A. E.

2 Rzeszotarska B.

2 Siodlak D.

1 Dybala I.

1 Kolodziejczyk E.

1 2004

1 2001

Wyniki wyszukiwania

Conformational properties of N',N'-dimethylamides of N-acetyldehydroalanine and N-acetyl-[Z]-dehydrophenylalanine

Conformational investigation of alpha,beta-dehydropeptides. XIII. Conformational properties of N-acetyl-alpha,beta-dehydrovaline N',N'-dimethylamide