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Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression

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Asada K., Inaba Y., Tateda-Suzuki E., Kuwahara-Arai K., Ito T., Hiramatsu K.

Acta Biochimica Polonica

1995

tom 42

nr 4

Methicillin-resistant Staphylococcus aureus (MRSA) has two mechanisms of resistance to P-lactam antibiotics; one is mediated by mecA gene expression, and the other by penicillinase production. It has been generally accepted in the clinical field that β-lactam antibiotics are not the drugs of choice for MRSA infection. In this report, however, ampicillin and penicillin G were shown to have relatively good activity against MRSA if combined with a β-lactamase inhibitor, sulbactam. These β-lactam antibiotics were found to have relatively high binding affinities to PBP2', the mecA-encoded MRSA-specific penicillin-binding protein. The possible therapeutic application of sulbactam/ampicillin against MRSA infection in combination with arbekacin, an aminoglycoside antibiotic newly developed and introduced into clinical use in Japan, is discussed.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Asada K.

1 Hiramatsu K.

1 Inaba Y.

1 Ito T.

1 Kuwahara-Arai K.

1 Tateda-Suzuki E.

1 1995

Wyniki wyszukiwania

Evolution and resistance expression of MRSA. Evaluation of beta-lactam antibiotics against a set of isogenic strains with different types of phenotypic expression