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1

Powinowactwo zewnatrzkomorkowej DD-karboksypeptydazy-transpeptydazy szczepu Saccharopolyspora erythraea PZH TZ 64-575 do zwiazkow B-laktamowych

100%
Solecka J., Kurzatkowski W.
Medycyna Doświadczalna i Mikrobiologia
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1999
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tom 51
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nr 1-2
151-165
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Tyrosine kinase, Aurora kinase and leucine aminopeptidase as attractive drug targets in anticancer therapy - characterisation of their inhibitors

100%
Ziemska J., Solecka J.
Roczniki Państwowego Zakładu Higieny
|
2016
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tom 67
|
nr 4
Cancers are the leading cause of deaths all over the world. Available anticancer agents used in clinics exhibit low therapeutic index and usually high toxicity. Wide spreading drug resistance of cancer cells induce a demanding need to search for new drug targets. Currently, many on-going studies on novel compounds with potent anticancer activity, high selectivity as well as new modes of action are conducted. In this work, we describe in details three enzyme groups, which are at present of extensive interest to medical researchers and pharmaceutical companies. These include receptor tyrosine kinases (e.g. EGFR enzymes) and non-receptor tyrosine kinases (Src enzymes), type A, B and C Aurora kinases and aminopeptidases, especially leucine aminopeptidase. We discuss classification of these enzymes, biochemistry as well as their role in the cell cycle under normal conditions and during cancerogenesis. Further on, the work describes enzyme inhibitors that are under in vitro, preclinical, clinical studies as well as drugs available on the market. Both, chemical structures of discovered inhibitors and the role of chemical moieties in novel drug design are discussed. Described enzymes play essential role in cell cycle, especially in mitosis (Aurora kinases), cell differentiation, growth and apoptosis (tyrosine kinases) as well as G1/S transition (leucine aminopeptidase). In cancer cells, they are overexpressed and only their inhibition may stop tumor progression. This review presents the clinical outcomes of selected inhibitors and argues the safety of drug usage in human volunteers. Clinical studies of EGFR and Src kinase inhibitors in different tumors clearly show the need for molecular selection of patients (to those with mutations in genes coding EGFR and Src) to achieve positive clinical response. Current data indicates the great necessity for new anticancer treatment and actions to limit off-target activity.
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Mobile telephony and its effects on human health

100%
Magiera A., Solecka J.
Roczniki Państwowego Zakładu Higieny
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2019
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tom 70
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nr 3
In recent years, there has been a rapid increase in the number of electromagnetic radiation sources such as mobile phones and base stations of mobile telephony. This radiation has been classified by the International Agency for Research on Cancer as a possible human carcinogen (group 2B). For this reason, many studies have been carried out on the impact of mobile telephony on human health. The largest of the experiments were carried out on animals. Due to the divergent results of many studies, there was no clear answer on the possible carcinogenic effects of this type of radiation on health. Detection of cancer shortly after an exposure is the most difficult task in analyzing the results. Some of the studies require repetition and verification of the results. In the case of negative effects of electromagnetic fields on brain activity, sleep, heart rate, cognitive function and blood pressure, no consistent evidence has been obtained either. In view of the increasing popularity of mobile phones, their location at short distances from the body (mainly the head) and the development of mobile phone technologies (which entails an increase in the number of base stations), further research, especially among young people, is needed. The duration of human exposure to electromagnetic radiation is subject to an increase and only further research can provide an answer on the possible negative effects of mobile phones and base stations.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Radiofrequency electromagnetic radiation from Wi-fi and its effects on human health, in particular children and adolescents. Review

100%
Magiera A., Solecka J.
Roczniki Państwowego Zakładu Higieny
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2020
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tom 71
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nr 3
5

DD-karboksypeptydazy-transpeptydazy

100%
Solecka J., Kurzatkowski W.
Postępy Mikrobiologii
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1998
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tom 37
|
nr 1
33-56
6

Miedzynarodowa Konferencja pt. Bionauka i Biotechnologia Wysokich Cisnien. 30.08.-3.09.1998 r. Heidelberg, Niemcy

81%
Kurzatkowski W., Solecka J., Rozbicka B., Laudy A.
Postępy Mikrobiologii
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1998
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tom 37
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nr 3
369-376
7
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Content available

Natural groundwaters in Poland - occurrence, properties and chemical types

81%
Ziemska J., Mazanska M., Szynal T., Solecka J.
Roczniki Państwowego Zakładu Higieny
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2020
|
tom 71
|
nr 4
8

Alfa-synukleina w fizjologii i patologii mozgu

81%
Solecka J., Adamczyk A., Strosznajder J. B.
Postępy Biologii Komórki
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2005
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tom 32
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nr 2
343-357
9
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Natural medicinal resources and their therapeutic applications

81%
Ziemska J., Szynal T., Mazanska M., Solecka J.
Roczniki Państwowego Zakładu Higieny
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2019
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tom 70
|
nr 4
Natural medicinal resources are a country’s natural wealth. Natural medicinal waters, medicinal gases, and peloids have many properties that enable their use in the treatment of gastrointestinal, circulatory, respiratory, bone and joint, and skin and soft tissue disorders. Balneotherapy can be also applicable in prevention of many diseases and rehabilitation. At present, because there are several chemicals of synthetic origin, there is a need to search for nonpharmacological approaches and explore natural healing sources, which better fit the human body. Compared to synthetic drugs, these resources rarely show side effects, which increases the comfort of therapy. The use of natural medicinal resources in the form of treatments in health resort medicine centers under the supervision of balneologists, combined with the healing properties of the climate, contributes not only to the reduction of treatment time for many diseases but also to improvement of therapy’s results. The article discusses natural medicinal resources and some of their therapeutic applications.
10
Content available remote

Expression of alpha-synuclein in different brain parts of adult and aged rats

80%
Adamczyk A., Solecka J., Strosznajder J. B.
Journal of Physiology and Pharmacology
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2005
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tom 56
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nr 1
The synucleins are a family of presynaptic proteins that are abundant in neurons and include alpha-, ß-, and -synuclein. alpha-Synuclein (ASN) is involved in several neurodegenerative age-related disorders but its relevance in physiological aging is unknown. In the present study we investigated the expression of ASN mRNA and protein in the different brain parts of the adult (4-month-old) and aged (24-month-old) rats by using RT-PCR technique and Western blot, respectively. Our results indicated that mRNA expression and immunoreactivity of ASN is similar in brain cortex, hippocampus and striatum but markedly lower in cerebellum comparing to the other brain parts. Aging lowers ASN mRNA expression in striatum and cerebellum by about 40%. The immunoreactivity of ASN in synaptic plasma membranes (SPM) from aged brain cortex, hippocampus and cerebellum is significantly lower comparing to adult by 39%, 24% and 65%, respectively. ß-synuclein (BSN) was not changed in aged brain comparing to adult. Age-related alteration of ASN may affect the nerve terminals structure and function.
11

Promieniowce - występowanie i wytwarzanie związków biologicznie czynnych

71%
Solecka J., Ziemska J., Rajnisz A., Laskowska A., Guspiel A.
Postępy Mikrobiologii
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2013
|
tom 52
|
nr 1
12

Secondary metabolites of actinomycetes and their antibacterial, antifungal and antiviral properties

71%
Jakubiec-Krzesniak K., Rajnisz-Mateusiak A., Guspiel A., Ziemska J., Solecka J.
Polish Journal of Microbiology
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2018
|
tom 67
|
nr 3
The growing resistance of microorganisms towards antibiotics has become a serious global problem. Therapeutics with novel chemical scaffolds and/or mechanisms of action are urgently needed to combat infections caused by multidrug resistant pathogens, including bacteria, fungi and viruses. Development of novel antimicrobial agents is still highly dependent on the discovery of new natural products. At present, most antimicrobial drugs used in medicine are of natural origin. Among the natural producers of bioactive substances, Actinobacteria continue to be an important source of novel secondary metabolites for drug application. In this review, the authors report on the bioactive antimicrobial secondary metabolites of Actinobacteria that were described between 2011 and April 2018. Special attention is paid to the chemical scaffolds, biological activities and origin of these novel antibacterial, antifungal and antiviral compounds. Arenimycin C, chromopeptide lactone RSP 01, kocurin, macrolactins A1 and B1, chaxamycin D as well as anthracimycin are regarded as the most effective compounds with antibacterial activity. In turn, the highest potency among selected antifungal compounds is exhibited by enduspeptide B, neomaclafungins A-I and kribelloside D, while ahmpatinin i Bu, antimycin A1a, and pentapeptide 4862F are recognized as the strongest antiviral agents.
13

Fuzja protoplazmow, genetyczna rekombinacja Streptomyces i biosynteza antybiotykow hybrydowych

61%
Kurzatkowski W., Filipek J., Solecka J., Rozbicka B., Laudy A. E., Starosciak B. J.
Postępy Mikrobiologii
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1998
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tom 37
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nr 3
305-339
14

Characterization and optimization of biosynthesis of bioactive secondary metabolites produced by Streptomyces sp. 8812

61%
Rajnisz A., Guspiel A., Postek M., Ziemska J., Laskowska A., Rabczenko D., Solecka J.
Polish Journal of Microbiology
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2016
|
tom 65
|
nr 1
The nutritional requirements and environmental conditions for a submerged culture of Streptomyces sp. 8812 were determined. Batch and fed-batch Streptomyces sp. 8812 fermentations were conducted to obtain high activity of secondary metabolites. In the study several factors were examined for their influence on the biosynthesis of the active metabolites-7-hydroxy-6-oxo-2,3,4,6-tetrahydroisoquinoline-3-carboxyl acid (C₁₀H₉NO₄) and N-acetyl-3,4-dihydroxy-l-phenylalanine (C₁₁H₁₃NO₅): changes in medium composition, pH of production medium, various growth phases of seed culture, amino acid supplementation and addition of anion exchange resin to the submerged culture. Biological activities of secondary metabolites were examined with the use of dd-carboxypeptidase 64–575 and horseradish peroxidase. Streptomyces sp. 8812 mycelium was evaluated under fluorescent microscopy and respiratory activity of the strain was analyzed. Moreover, the enzymatic profiles of the strain with the use of Api®ZYM test were analyzed and genetic analysis made. Phylogenetic analysis of Streptomyces sp. 8812 revealed that its closest relative is Streptomyces capoamus JCM 4734 (98%), whereas sequence analysis for 16S rRNA gene using NCBI BLAST algorithm showed 100% homology between these two strains. Biosynthetic processes, mycelium growth and enzyme inhibitory activities of these two strains were also compared.
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