Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 10

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Badano wpływ doustnego 8 tyg. narażenia szczurów na rtęć (150 mg/dm3 w przeliczeniu na czysty metal) wprowadzana do ustroju w postaci roztworu HgCl2 na tkankowe stężenia magnezu, wapnia i krzemu. W większości tkanek stwierdzono statystycznie istotne zmiany w przypadku ste˛z˙enia magnezu i wapnia, natomiast nie zaobserwowano zmian w ste˛z˙eniu krzemu.
Magnesium and selenium belong to important bioelements. Magnesium is the second most abundant intracellular macroelement, which takes part in the metabolism of carbohydrates, nucleic acids, protein and lipids. Selenium is an essential microelement, whose deficit has been stated in many different pathological states. Much research on safe and effective selenium supplementation has been performed for the last fifty years but the results still remain unsatisfactory. The aim of our study was to investigate the influence of inorganic sodium selenite Na2SeO3 and two selenoorganic compounds synthetized at our chair on magnesium concentration in tissues of adolescent male Wistar rats. Inorganic selenite was administered as a water solution, whereas organic compounds: 4-(o-tolilo)-selenosemikarbazyd of 2-chlorobenzoic acid of a chain structure (ORG-C) and 3-(o-chlorobenzoylamino)-2-(o-tolylimino)-4- -methyl-4-selenazoline of a ring structure (ORG-R) were suspended in emulsion (oil, arabic gum and water). Selenium compounds were given to rats at a dose of 5⋅10–4 mg Se g–1 b.w. once a day for a period of 10 days. The control group was treated with saline. The administration was performed with use of a stomach tube. In comparison to the control group, selenium supplementation caused decrease in magnesium concentration in kidney and lung tissues, but did not cause any changes in the brain and heart muscle. In the liver and spleen it was only ring selenazoline that affected magnesium concentration, increasing it in the liver and decreasing in the spleen. In the femoral muscle it was only the selenosemicarbazide chain that exerted the significant effect causing a decrease in Mg concentration vs the control group. Selenium supplementation influences the tissue magnesium concentrations depending on tissue and structure of the supplement. Irrespective of the administered compound, it lowered magnesium in kidneys and lungs but caused no changes in the brain and heart muscle. In the liver, spleen and femoral muscle, alterations in the magnesium concentration were dependent on the provided supplement.
Lithium compounds are widely employed in medicine. However, both its positive and negative effects have been revealed. We have tried to evaluate the influence of oral administration of different Li2C03 doses for a period of 8 weeks on the elements of antioxidant status in male rats. The activity of two main antioxidant enzymes: glutathione peroxidase (GPx) and superoxide dismutase (SOD) as well as the con­centration of malonyldialdehyde (MDA) - the marker of lipid peroxidation - have been studied. In blood no significant changes of both lipid peroxidation levels and enzyme activity have been found. In tissues enzymes' activities have decreased, significantly in liver (SOD) and kidney (GPx and SOD). No evidence of lithium-induced lipid peroxidation in the tissues has been observed. In the case of brain the Li protective effect against lipid peroxidation has been displayed. In conclusion, the antioxidant status has not been af­fected in blood and suppressed in tissues as a consequence of Li exposure. The tissue of brain has seemed to be the least attacked organ.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.