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Genetic basis for cholecystolithiasis. Existing state of knowledge

100%

Lodej P., Madej-Czerwonka B., Wojciechowska K., Niedobit A., Kocki J.

Journal of Pre-Clinical and Clinical Research

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2013

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tom 07

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nr 1

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Disruption of mitochondrial function augments the radiosensitivity of prostate cancer cell lines

100%

Adamczuk G. M., Humeniuk E., Adamczuk K., Madej-Czerwonka B., Dudka J.

Annals of Agricultural and Environmental Medicine

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2023

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tom 30

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nr 1

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Effect of iodothyronine hormone status on doxorubicin related cardiotoxicity

72%

Dudka J., Mandziuk S., Madej-Czerwonka B., Sierocinska-Sawa J., Walczyna B., Korga A., Cendrowska-Pinkosz M., Burdan F.

Folia Morphologica

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2013

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tom 72

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nr 4

The anthracycline anticancer agent doxorubicin has been recognised to induce a dose-dependent cardiotoxicity. The chronic form of such complication is characterised by an irreversible cardiac damage and congestive heart failure. Although the pathogenesis of anthracycline cardiotoxicity seems to be multifactorial, the pivotal role has been attributed to reactive oxygen species formation. Because redox equilibrium in cardiomyocytes may be regulated via iodothyronine hormones, the aim of the study was to appraise the effect of hypothyroidism on heart damages induced by doxorubicin. The rats received methimazole in drinking water (0.001 and 0.025%) after doxorubicin administration (2.0, 5.0 and 15 mg/kg). The cardiac morphology and blood biochemical markers of heart damage were assessed. Decreased levels of iodothyronine hormones had not significant impact on cardiac morphological changes and no effect on the level of B-type natriuretic peptide in rats receiving doxorubicin. Lower hormonal levels had sporadic, diverse effect on blood transaminases, lactate dehydrogenase and creatine kinase levels, but any relation to time, doxorubicin doses and hypothyroid status was found. Hypothyreosis leads to increase in fatty acid binding protein in rats receiving higher dose of doxorubicin. Hypothyreosis had no effect on heart stretching and on necrosis at morphological level, but caused biochemical symptoms of cardiomyocyte necrosis in rats receiving doxorubicin. (Folia Morphol 2013; 72, 4: 340–348)

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Influence of caffeine used at various temperature ranges on the concentrations of glucose and total serum protein as well as body weight gain in pregnant rats

72%

Cendrowska-Pinkosz M., Luszczewska-Sierakowska I., Dworzanski W., Tomaszewski M., Krauze M., Grzebalska A. M., Madej-Czerwonka B., Burdan F.

Bulletin of the Veterinary Institute in Puławy

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2014

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tom 58

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nr 2

Caffeine (120 mg/kg) was administered intragastrically to pregnant rats daily on gestational days 8-21. An increase in serum concentration of glucose and total protein was found in animals, which were given caffeine. The protein content proved to be highly significant in the experimental group of animals. The control group showed a negative interdependence between body weight gain and glucose concentration. No correlation was found between body weight gain and total protein concentration, yet the glucose concentration significantly influenced the total protein concentration in this group of animals. Among animals which received caffeine, correlations between total protein and glucose concentrations were observed. The analysis did not show that the glucose or total protein concentration significantly influenced the body weight gain of pregnant female rats in the experimental group. The research conducted suggests the possibility of modulating effects of caffeine on adaptive processes during pregnancy.

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Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture

72%

Mandziuk S., Kus P., Dudka J., Madej-Czerwonka B., Cendrowska-Pinkosz M., Iwan M., Luszczewska-Sierakowska I., Korga A.

Medycyna Weterynaryjna

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2014

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tom 70

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nr 05

The main goal of the study was to determine whether hypoxia augments the toxicity of anticancer drugs towards cardiomyocytes. Drugs selected for this experiment were those that disturb the cardiac redox equilibrium. Cardiomyocytes were incubated for 24 h with doxorubicin, tirapazamine, and 5-fluorouracil, each at three doses, under normoxia and under 50% and 90% hypoxia. The cytotoxic effect was evaluated on the basis of the percentage of living cells, cell vitality (assessed by the MTT assay), and morphology. In addition, the oxidative marker and pH value were determined. Varied protective effects of hypoxia on cell morphology were observed in all cases except the medium concentration of tirapazamine. The 50% hypoxia prevented the toxic effects of all tested drugs. The 90% hypoxia, on the other hand, was effective against the cytotoxic action of doxorubicin and 5-fluoruracil, but the cytotoxicity of tirapazamine increased. It was found that under the 90% hypoxia the oxidative stress observed under normoxia and the 50% hypoxia was greatly reduced. The study revealed that the above drugs did not activate anaerobic glycolysis.

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2,4-dinitrophenol enhances cisplatin and etoposide cytotoxic activity on prostate cancer cell line

72%

Adamczuk G., Humeniuk E., Adamczuk K., Grabarska A., Madej-Czerwonka B., Michalczuk M., Korga-Plewko A., Dudka J.

Annals of Agricultural and Environmental Medicine

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2024

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tom 31

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nr 1

Ograniczanie wyników

Genetic basis for cholecystolithiasis. Existing state of knowledge

Disruption of mitochondrial function augments the radiosensitivity of prostate cancer cell lines

Effect of iodothyronine hormone status on doxorubicin related cardiotoxicity

Influence of caffeine used at various temperature ranges on the concentrations of glucose and total serum protein as well as body weight gain in pregnant rats

Effect of hypoxia on toxicity induced by anticancer agents in cardiomyocyte culture

2,4-dinitrophenol enhances cisplatin and etoposide cytotoxic activity on prostate cancer cell line