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Naive helper T cells from BCG-vaccinated volunteers produce IFN-gamma and IL-5 to mycobacterial antigen-pulsed dendritic cells

100%

Kowalewicz-Kulbat M., Kazmierczak D., Donevski S., Biet F., Pestel J., Rudnicka W.

Folia Histochemica et Cytobiologica

2008

tom 46

nr 2

153-157

Mycobacterium bovis BCG mycobacteria - new application

100%

Kowalewicz-Kulbat M., Pestel J., Biet F., Locht C., Tonnel A. B., Druszczynska M., Rudnicka W.

Polish Journal of Microbiology

2006

tom 55

nr 1

The polarized response of T helper-2 (Th2) lymphocytes to an allergen is considered to be the main cause of the pathogenesis of asthma. In this study, we asked a question whether M. bovis BCG mycobacteria which are known for the preferential stimulation of T helper-1 (Th1) immunity, diminish the effector functions of Th2 cells from allergic patients upon stimulation with a common house dust mite Der p-1 allergen. Our results allow a positive answer to this question. We demonstrate that BCG modulates the dendritic cell-dependent allergen presentation process and switches naive T lymphocytes towards an anti-allergic Th1 profile.

Ograniczanie wyników

1 Folia Histochemica et Cytobiologica

1 Polish Journal of Microbiology

2 Biet F.

2 Kowalewicz-Kulbat M.

2 Pestel J.

2 Rudnicka W.

1 Donevski S.

1 Druszczynska M.

1 Kazmierczak D.

1 Locht C.

1 Tonnel A. B.

1 2008

1 2006

Wyniki wyszukiwania

Naive helper T cells from BCG-vaccinated volunteers produce IFN-gamma and IL-5 to mycobacterial antigen-pulsed dendritic cells

Mycobacterium bovis BCG mycobacteria - new application