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1

Interaction of lead and cadmium with chosen microelements-health effects

100%
Moniuszko-Jakoniuk J., Brzoska M. M.
Biological Bulletin of Poznań. Supplement
|
1996
|
tom 33
2

Ocena zanieczyszczenia metalami ciezkimi wod Zalewu Dojlidy polozonego na terenie Bialegostoku - badania w latach 2006-2007

81%
Lewandowska I., Galazyn-Sidorczuk M., Brzoska M. M.
Ochrona Środowiska i Zasobów Naturalnych
|
2007
|
nr 31
366-370
3

The influence of lead intoxication on calcium and magnesium concentration in rat serum and tissue

81%
Brzoska M. M., Jurczuk M., Zaborowski J., Moniuszko-Jakoniuk J.
Acta Poloniae Toxicologica
|
1997
|
tom 05
|
nr 2
207-215
4

Thyroid and parathyroid function and structure in male rats chronically exposed to cadmium

81%
Pilat-Marcinkiewicz B., Brzoska M. M., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2008
|
tom 17
|
nr 1
113-120
The effect of exposure to cadmium (Cd) on the function and structure of the thyroid with parathyroids and a relationship between Cd accumulation in these glands and their damage were studied on a male rat model corresponding to human exposure. For this purpose, male rats were treated with Cd in drinking water at concentration of 5 and 50 mg Cd/dm³ for 12 and 24 weeks. The function of the thyroid was evaluated based on the measurement of serum concentrations of triiodothyronine (T₃) and tetraiodothyronine (T₄), and immunohistochemical identification of hormones such as calcitonin (CT), calcitonin-gene related peptide (CGRP) and somatostatin (ST). To assess the parathyroid function immunohistochemical reaction for parathyroid hormone-related peptide (PTHrP) was performed. Histological structure of the thyroid and parathyroid glands was evaluated in a light microscope. Rats exposed to 5 and 50 mg Cd/dm³ showed changes in the epithelium of follicular cells, intensified remodeling of the glandular structure of the thyroid, mononuclear cell infiltrations in connective tissue and pale staining of colloid. Hypertrophy and hyperplasia of endocrine parathyroid cells were evident.The intensity of reactions for CT, ST, CGRP and PTHrP was weakened. Exposure to Cd had no effect on the T₃ and T₄ serum concentrations, except for a marked increase in the concentrations of both hormones after 24 weeks of exposure to 50 mg Cd/dm³ . All the Cd-induced changes were much more advanced at exposure to 50 mg Cd/dm³ than 5 mg Cd/dm³ . The seriously disturbed structure and function of the thyroid and parathyroids at a low Cd concentration (0.087 ± 0.005 µg/g) in these glands suggests that the damaging Cd influence may be due to its indirect rather than direct action. Based on the results it can be hypothesized that a human body chronically exposed to moderate and relatively high Cd levels may be at risk of damage to the thyroid and parathyroid glands.
5

Disturbances in calcium metabolism in rats after oral cadmium intoxication

81%
Brzoska M. M., Jurczuk M., Moniuszko-Jakoniuk J.
Acta Poloniae Toxicologica
|
1997
|
tom 05
|
nr 1
91-97
6

The influence of ethanol on magnesium body status

81%
Pacewicz T., Moniuszko-Jakoniuk J., Brzoska M. M.
Polish Journal of Environmental Studies
|
2008
|
tom 17
|
nr 4
447-456
Magnesium (Mg) is the second most important intracellular cation that is needed for a broad variety of physiological functions. Disturbances in Mg body status, which may be induced by environmental contaminants, life style and manner of nutrition, can create serious negative consequences for health. One of the factors affecting Mg homeostasis is excessive ethanol consumption. Interactions between ethanol and Mg can take place at different stages of Mg metabolism (absorption, distribution in the organism and excretion of this element) as well as at the stage of its biological functions. Ethanol ingestion leads to serious disturbances in Mg metabolism on the one hand, while dietary Mg intake has been reported to influence the metabolism and toxicity of ethanol on the other. Experimental data show that Mg supplementation may prevent or reduce adverse effects of ethanol action in animals, whereas its deficiency can intensify ethanol toxicity. In this review, the interactions between ethanol and Mg in humans and animals are discussed on the basis of the available clinical, epidemiological and experimental data, against the background of common ethanol consumption and insufficient Mg dietary intake in the general population.
7

Effect of cadmium on collagen content and solubility in rat bone

81%
Galicka A., Brzoska M. M., Sredzinska K., Gindzienski A.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 3
The toxic action of cadmium in the bone tissue is known, but its mechanisms are still unexplained. We examined whether Cd influences collagen content and its solu­bility in the femoral bone of three-week-old female rats exposed to 5 or 50 mg Cd/l in drinking water. Non-cross linked collagen was extracted with 0.5 M acetic acid, and two acid-insoluble collagen fractions were extracted with pepsin and 4.0 M guanidine hydrochloride, respectively. SDS/PAGE showed the presence of two colla­gen types, I and V, in all three extracted fractions. Exposure of rats to Cd for 6 months increased the amount of acid-soluble collagens type I and V and decreased the level of acid-insoluble collagens. The amount of total collagen extracted from the bones of rats exposed to 50 mg Cd/l was reduced by about 14% as compared to con­trol and those intoxicated with 5 mg Cd/l. The solubility of type I bone collagen (de­termined as the percentage of acetic-soluble fraction of total collagen) was increased 2.9- and 3.0-fold in rats intoxicated with 5 and 50 mg Cd/l, respectively. Similarly, the solubility of type V collagen was increased 2.3- and 2.7-fold, respectively. Our re­sults indicate that Cd treatment affects bone collagen by decreasing its content and increasing its solubility.
8

Vitamins E and C concentrations in the liver and kidney of rats exposed to cadmium and ethanol

81%
Jurczuk M., Moniuszko-Jakoniuk J., Brzoska M. M., Roszczenko A.
Polish Journal of Environmental Studies
|
2005
|
tom 14
|
nr 5
In the present study, the effect of co-exposure to cadmium (Cd) and ethanol (EtOH) on concentrations of vitamins E and C were evaluated in the liver and kidney homogenates of rats which were administered, singly or in combination, Cd (50 mg Cd/dm3 in drinking water) and EtOH (5 g EtOH/kg b. wt./24 h, intragastrically) for 12 weeks. The exposure to Cd caused a decrease in the concentration of vitamins E and C in the liver, whereas the concentration of vitamin E increased in the kidney, compared to control group. EtOH administration led to a decrease in vitamins E and C concentrations in the liver. Exposure to Cd alone enhanced the concentration of vitamin C in the kidney. In the co-exposed group, the concentration of vitamin E decreased in the liver as compared to control and Cd group but increased in comparison to EtOH group. The concentration of vitamin C in this organ decreased compared to control and Cd- or EtOH-exposed groups. The co-exposure to both substances caused a rise in vitamin E concentration in the kidney compared to control and EtOH groups, whereas the concentration of vitamin C increased compared to control and Cd group. In the liver positive correlation was noted between vitamin E or C concentrations and glutathione (GSH) concentration. In the kidney, negative correlation was found between the concentration of vitamin E and GSH. No correlation was observed between the concentration of vitamin C and GSH in this organ. The results obtained suggest that the change in vitamin E concentration in the liver of rats co-exposed to Cd and EtOH resulted from an independent action of EtOH and its interaction with Cd, whereas in the kidney it was due to an independent Cd effect. In the animals co-exposed to Cd and EtOH, the change in vitamin C detected in the liver was the result of an independent action of either Cd or EtOH. In the kidney, the concentration of vitamin C was only EtOH-dependent. The results of this study together with our previous finding in the model used suggest the involvement of vitamins E and C in the development of Cd- and/or EtOH-induced oxidative stress.
9

Urinary activities of N-acetyl-beta-D-glucosaminidase and its isoenzyme B in cadmium-exposed rats

81%
Brzoska M. M., Stypulkowska A., Zwierz K., Moniuszko-Jakoniuk J.
Polish Journal of Environmental Studies
|
2004
|
tom 13
|
nr 2
This paper aims to assess the relationship between the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) and its isoenzyme B (NAG-B) and cadmium (Cd) concentration in the urine as well as to evaluate which of these lysosomal enzymes may be a more useful biomarker for the monitoring of Cd-induced tubular damage. For this purpose we have used an experimental model in rats chronically exposed to Cd in which we noted damage to the proximal tubules, including lysosomes. In rats intoxicated with 5 mg Cd/dm3, the urinary activities of NAG and NAG-B increased after 12 weeks of treatment, while at 50 mg Cd/dm3 - activities increased already after the 1st week. The urinary Cd excretion in Cd-exposed rats, but not in the non-exposed ones, positively correlated with the activities of NAG and NAG-B. A positive correlation which was observed between NAG and NAG-B activities was stronger in Cd-exposed animals than in those not exposed. The results of the present and our previous histopathological and histoenzymatic studies, confirm the usefulness of total NAG and NAG-B as sensitive markers of proximal tubular injury for the monitoring of chronic exposure to Cd. Taking into account the strong correlation between the total NAG and its isoenzyme B, similar correlation coefficients between their activities and Cd concentration in urine and simplicity of total NAG determination compared to that of NAG-B, one can conclude that the determination of total NAG is suitable for the monitoring of exposure to Cd. As the urinary activity of total NAG is a sum of activities of several isoenzymes, which may be influenced by various factors, and the intralysosomal localization of NAG-B, we hypothesize that NAG-B should be recommended as a sensitive and useful marker for routine monitoring of chronic exposure to Cd.
10

Lead turnover and changes in the body status of chosen micro- and macroelements in rats exposed to lead and ethanol

81%
Moniuszko-Jakoniuk J., Jurczuk M., Galazyn-Sidorczuk M., Brzoska M. M.
Polish Journal of Environmental Studies
|
2003
|
tom 12
|
nr 3
The effect of continuous exposure to lead (Pb) and ethanol on Pb turnover and zinc (Zn), copper (Cu), iron (Fe), calcium (Ca) and magnesium (Mg) body status was studied in male Wistar rats. The animals received an aqueous solution of 10% (w/v) ethanol and/or 500 μg Pb/cm³ as the only drinking fluid for 12 weeks. Exposure to Pb as well as ethanol alone influenced the body status of Zn, Cu, Fe, Ca and Mg. Disturbances in their metabolism were reflected in decreased bioavailability, changes in serum and/or tissue concentrations and urinary excretion. The most serious disorders under Pb influence were observed in Fe metabolism, while ethanol alone disturbed mainly Fe, Cu and Zn body status. In the conditions of co-exposure to Pb and ethanol some changes were more or less evident and sometimes they had different direction than at separate intoxication. Moreover, simultaneous exposure to Pb and ethanol led to changes in the concentrations of Cu, Fe and Mg, which were not observed in the case of separate administration. The independent action of Pb and/or ethanol as well as the interactive effect of both substances involving the modifying influence of ethanol on Pb turnover could explain the changes in the metabolism of bioelements under combined exposure to Pb and ethanol. Our results seem to indicate that Pb-exposed human subjects abusing ethanol may be more vulnerable to the accumulation of Pb in body organs and metabolic disorders of some bioelements, which may in consequence enhance the risk of health injury.
11

Effect of chronic administration of cadmium on the rat thyroid: radioimmunological and immunohistochemical studies

81%
Pilat-Marcinkiewicz B., Sawicki B., Brzoska M. M., Moniuszko-Jakoniuk J.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
12

Structure and function of thyroid follicular cells in female rats chronically exposed to cadmium

81%
Pilat-Marcinkiewicz B., Brzoska M. M., Sawicki B., Moniuszko-Jakoniuk J.
Bulletin of the Veterinary Institute in Puławy
|
2003
|
tom 47
|
nr 1
13

The influence of ethanol on zinc concentration in Cd-exposed rats

81%
Galazyn-Sidorczuk M., Brzoska M. M., Moniuszko-Jakoniuk J., Kowalczyk M.
Polish Journal of Environmental Studies
|
1998
|
tom 07
|
nr 1
The aim of this study was to examine the influence of oral intoxication with cadmium and ethanol separately or together on zinc concentrations in liver and kidney of rats. Cadmium was administered at a concentration of 50 mg Cd/dm3 in drinking water for 8 weeks. Ethanol was given in a dose of 5 g/kg of body weight (as a 25% solution) every 12 h for the last 108 h of the experiment. The conducted study has shown that intoxication with cadmium and ethanol alone as well as in combination leads to an increase in zinc concentrations in the liver and kidney. The elevation of zinc levels is highest when the rats are co-exposed to cadmium and ethanol. The deposition of zinc in the liver and kidney of cadmium intoxicated rats is associated with cadmium accumulation and induction of metallothionein synthesis in these organs. Ethanol is also able to induce metallothionein synthesis and an elevation of zinc concentrations in the liver and kidney. As a result, in conditions of co-exposure these effects sum up.
14

The influence of oral cadmium intoxication on chosen hematological parameters in rats

71%
Jurczuk M., Brzoska M. M., Galazyn-Sidorczuk M., Moniuszko-Jakoniuk J., Kemona A.
Acta Poloniae Toxicologica
|
1997
|
tom 05
|
nr 1
85-90
15

Wplyw kadmu na gospodarke wapniowa w ustroju szczura

71%
Brzoska M. M., Jurczuk M., Moniuszko-Jakoniuk J., Roszczenko A., Bartosiewicz E.
Bromatologia i Chemia Toksykologiczna
|
1996
|
tom 29
|
nr 1
35-39
Badano wpływ doustnego 8 tyg. narażenia szczurów na kadm 5 i 50 mg/dm3, wprowadzonego do ustroju w postaci wodnych roztworów CdCl2, na wybrane wskaźniki gospodarki wapniowej. Stwierdzono wzrost wydalania wapnia z moczem oraz obniżenie jego stężenia w surowicy, kości udowej i nerce. Poziom tego pierwiastka w wątrobie i śledzionie nie uległ zmianie.
16

Involvement of some low-molecular thiols in the destructive mechanism of cadmium and ethanol action on rat livers and kidneys

71%
Moniuszko-Jakoniuk J., Jurczuk M., Brzoska M M., Rogalska J., Galazyn-Sidorczuk M.
Polish Journal of Environmental Studies
|
2005
|
tom 14
|
nr 4
The involvement of some low-molecular thiol compounds in the mechanisms of peroxidative action of cadmium (Cd) and ethanol (EtOH) was studied. Concentrations of reduced glutathione (GSH), metallothionein (Mt) and thiol (-SH) groups in protein and non-protein fractions were assessed in the homogenates of the liver and kidney of rats exposed to Cd (50 Cd/dm³ of drinking water) and EtOH (5 g EtOH/kg body weight/24 h, intragastrically), singly or in combination, for 12 weeks. Exposure to Cd caused a reduction in the concentration of GSH and non-protein SH groups in the liver and kidneys with a simultaneous increase in Mt level in these organs. The concentration of total SH groups increased only in kidneys. Administration of EtOH had no effect on Mt concentration in both organs, but caused a reduction in the concentration of GSH and non-protein SH groups. A reduction in the level of total SH groups following exposure to EtOH was also noted in the liver. In the group of rats with a simultaneous exposure to Cd and EtOH, GSH concentration was decreased in the liver compared to the control and Cd-exposed animals, and in the kidney in comparison to the control and EtOH-receiving rats. Following the combined exposure to Cd and EtOH, the concentration of non-protein SH groups decreased in the liver and kidneys in comparison to the control and Cd-exposed rats, and in the liver also in comparison to the EtOH group. Mt concentration increased in the liver and kidneys of animals exposed to a combination of Cd and EtOH, compared to the control and EtOH group, but was reduced compared to the Cd group. Combined administration of Cd and EtOH caused an increase in the concentration of total SH groups in the kidneys compared to the control, Cd and EtOH groups. A negative correlation was found between GSH concentration and malondialdehyde (MDA) levels and positive correlation between Mt and MDA. The intensity of lipid peroxidation as well as GSH and Mt concentrations influencing this process in the state of combined exposure to Cd and EtOH results both from independent actions of these substances and interactions between them. The study outcome seems to indicate that the Cd- and EtOH-induced reduction in GSH and non-protein SH groups in the liver and kidneys may be one of the mechanisms that leads to lipid peroxidation in these organs.
17

Effect of long-term cadmium treatment on apoptosis and proliferation of rat kidney cells

61%
Plewka D., Nowaczyk G., Plewka A., Brzoska M. M., Szczepanik T., Moniuszko-Jakoniuk J.
Acta Toxicologica
|
2007
|
tom 15
|
nr 2
141-148
18

Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures

61%
Zalewska A., Brzoska M. M., Marciniak J., Karaszewska K., Zwierz K., Moniuszko-Jakoniuk J.
Acta Biochimica Polonica
|
2004
|
tom 51
|
nr 3
Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "envi­ronmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of ß-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, ß-N-acetylhexosa- minidase showed the highest activity. The activities of a-mannosidase and ß-galacto- sidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.
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