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1

New targets and strategies in anticancer treatment

100%
Radzikowski C., Wietrzyk J.
Acta Biochimica Polonica
|
2006
|
tom 53
|
nr Supplement 1
2

The influence of a single and double biotinylation of xanthohumol on its anticancer activity

81%
Stompor M., Switalska M., Wietrzyk J.
Acta Biochimica Polonica
|
2019
|
tom 66
|
nr 4
3

Novel Ru[III], Rh[III], Pd[II] and Pt[II] complexes with ligands incorporating azole and pyrimidine rings. I. Antiproliferative activity in vitro

80%
Wisniewski M. Z., Wietrzyk J., Opolski A.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
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tom 48
|
nr 1
4

The role of copper in tumor angiogenesis

80%
Nasulewicz A., Wietrzyk J., Opolski A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
5

Isophosphoramide mustard analogues as prodrugs for anticancer gene-directed enzyme-prodrug therapy [GDEPT]

71%
Misiura K., Szymanowicz D., Kusnierczyk H., Wietrzyk J., Opolski A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 1
Two types of prodrugs, benzyl analogues of isophosphoramide mustard (iPAM), ac­tivated by cytochrome P450, and acylthioethyl analogues, activated by esterases, were designed. In contrast to iPAM that hydrolyse rapidly, the examined compounds are stable in phosphate-buffered saline and Tris buffer. Benzyl analogues of iPAM are poor substrates for cytochrome P450, are not cytotoxic and posses no antitumour ac­tivity. Acylthioethyl analogues of iPAM are good substrates for pig liver esterase, are cytotoxic and exert antitumour activity against L1210 leukaemia in mice. The ob­served correlation for iPAM analogues between their susceptibility to hydrolysis and cytotoxicity and antitumour activity suggests possible application of these compounds as the prodrugs in gene-directed enzyme-prodrug therapy.
6

Synthesis and biological evaluation of 4'-O-acetyl-isoxanthohumol and its analogues as antioxidant and antiproliferative agents

61%
Stompor M., Switalska M., Podgorski R., Uram L., Aebisher D., Wietrzyk J.
Acta Biochimica Polonica
|
2017
|
tom 64
|
nr 3
7

Relationship between magnesium status and the growth and metastasis of experimental mouse tumours

51%
Nasulewicz A., Wietrzyk J., Wolf F. I., Dzimira S., Madej J., Maier J. A. M., Rayssiguier Y., Mazur A., Opolski A.
Journal of Elementology
|
2005
|
tom 10
|
nr 4 Suppl.1
73-74
8

In vitro anti-cancer properties of natural vs synthetic conjugated linoleic acid

51%
Lipkowski A. W., Walisiewicz-Niedbalska W., Patkowska-Sokola B., Opolski A., Bodkowski R., Wietrzyk J., Pelczynska M., Nasulewicz A., Gwardiak H., Kwiatkowski J.
Animal Science Papers and Reports
|
2003
|
tom 21
|
nr 1
Anti-proliferative activity was investigated of C18:2 9cis,11trans (conjugated linoleic acid – CLA) isomer isolated from sheep milk fat. The research was conducted on sheep milk fatty acids in natural composition (FA-1) containing 2.0% of the C18:2 9cis,11trans CLA isomer and preparation enriched with CLA, containing up to 9.2% of the CLA isomer (FA-2). The process of enrichment of FA-1 was carried out in two steps. Step I was to remove mid-chain-length saturated fatty acids, primarily C16,by forming adducts with urea (to obtain FA-U), while in step II the short-chain acids were removed by way of supercritical extraction with CO2. The final preparation obtained (FA-2) contained 9.2% of the C18:2 9cis,11trans isomer. A natural sheep milk fatty acid composition (FA-1), the CLA-enriched product (FA-2) and a commercial CLA preparation (CP) were tested for anti-proliferative activity against the cells of human cervical carcinoma (KB), and leukaemia (HL-60). The ID50 dose (resulting in a 50% inhibition of cell proliferation) of FA-2 was found lower than that of the CP preparation. The SRB test showed.
9

The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen [CEACAM5] expression

51%
Baczynska D., Wietrzyk J., Madej J., Krop-Watorek A., Dabrowska A., Widerak K., Opolski A., Ugorski M.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 2
It was shown that CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions; however, its role in the expression of the malignant phenotype remains obscure. To study whether the formation of both primary tumors and metastases is directly related to the presence or absence of CEACAM5, we applied the antisense RNA strategy. By transfecting human CX-1.1 colon carcinoma cells with CEACAM5 antisense-expressing vector or with the vector itself, cell variants with a highly decreased expression of CEACAM5 were obtained. Profound differences in proliferative abilities among parental and obtained subclones of CX-1.1 cells were revealed when cells were implanted subcutaneously into nude mice. In contrast to their highly tumorigenic parental CX-1.1 cells (with high expression of membrane-bound and secreted CEACAM5), two subclones (3E and AS6Q) with substantially decreased expression of membrane-bound and secreted CEA showed a considerably diminished growth rate. Even more striking results were obtained with AS8Q cells, producing a residual amount of this glycoprotein. However, 3B cells (producing a large amount of secreted CEACAM5) did not differ significantly in their tumorigenic properties from CX-1.1 cells. Our experiments performed in nu/nu mice suggest that CEACAM5 supports the growth of primary tumors, but is not involved in the formation of metastases by colon cancer cells.
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