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1

Pierwszy Krajowy Kongres Biotechnologii, 20-25 września 1999 r.

100%
Kafarski P.
Biotechnologia
|
2000
|
nr 1
2

Biotransformacje jako narzędzie w procesach biorafinacji

88%
Kafarski P.
Postępy Mikrobiologii. Suplement
|
2017
|
tom 56
|
nr 2
3

Rational design of herbicides

63%
Kafarski P., Berlicki L.
Pestycydy
|
2004
|
nr 3-4
4

Studies on degradation of polychlorinated biphenyls by means of Fenton's reagent

51%
Przado D., Kafarski P., Steininger M.
Polish Journal of Environmental Studies
|
2007
|
tom 16
|
nr 6
881-887
Fenton's reagent was applied for degradation of selected congeners of PCBs (PCB28, PCB52, PCB101, PCB138) present in aqueous solution at ppb concentrations. The effectiveness of degradation by this chemi­cal process was determined and the toxicity of degradation products was evaluated. The experiments lasted 96 hours under stable pH during the whole process. In 24 h intervals the samples were extracted and analyzed by GC, GC/MS and IC. At the same time the Microtox® test was applied to assess the toxicity of the resulting solution. It has been observed that the concentration of two congeners, namely PCB28 and PCB52, decreased rapidly within the first 24 h of the experiment, whereas the two remaining ones (PCB101, PCB138) were degraded poorly. After 96 hours of the process, apart from other oxygenated products, acetate and fumarate also were determined. Concentration of Cl- ions was only slightly increased, indicating that the substrates were not mineralized.
5

Transport of dipertides through supported liquid membranes

51%
Wieczorek P. P., Bryjak M., Kafarski P., Lejczak B.
Biophysics of Membrane Transport
|
1990
|
tom 10
|
nr 2
6

Molekularny mechanizm dzialania bisfosfonianow i ich zastosowanie w praktyce klinicznej

51%
Mytnik E., Kuryszko J., Chmielewska E., Kafarski P.
Medycyna Weterynaryjna
|
2010
|
tom 66
|
nr 05
307-310
Bisphosphonates are a unique class of drugs. As a family they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution and elimination. Bisphosphonates have become the most important class of antiresorptive drugs, not only for the treatment of Paget’s disease, but also for other diseases that involve excessive osteoclast-mediated bone resorption, such as tumor-induced osteolysis and hypercalcemia as well as osteoporosis. Although all bisphosphonates have similar psychochemical properties, their antiresorbing activities differ substantially. The structure of the R2 side chain is the major determinant of antiresorptive potency, both phosphonate groups are also required for the drugs to be active. Activity is dramatically increased when the amino group is contained in the aliphatic carbon chain. They act by inhibiting the enzyme farnesyl diphosphate synthase. Despite this, the molecular mode of their action is still not clear. There is substantial evidence that BPs can have a direct effect on osteoclasts by mechanisms that may lead to osteoclast cell death by apoptosis. BPs can also inhibit proliferation and cause cell death in macrophages in vitro. It has been shown that the toxic effect of BPs on macrophages is also due to the induction of apoptotic, rather than necrotic, cell death. Bisphosphonates may inhibit osteoclast-mediated bone resorption by several routes, although a direct effect on mature osteoclasts is the most likely. Bisphosphonates perturb cellular metabolism and induce osteoclast apoptosis. The molecular mechanisms by which these effects are brought about are only now becoming clear. The simple bisphosphonates that closely resemble pyrophosphonates (such as clodronate, etidronate and tiludronate) can be metabolically incorporated into non-hydrolysable analogues of ATP that accumulate intracellularly in osteoclasts, resulting in the induction of osteoclast apoptosis. The more potent, nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signaling proteins. Loss of bone-resorptive activity and osteoclast apoptosis is primarily due to the loss of geranylgeranylated small GTPases.
7

The influence of alpha-aminophosphonic acids on the activity of aminopeptidase from barley seeds-an approach to determine the enzyme specificity

51%
Oszywa B., Pawelczak M., Kafarski P.
Acta Physiologiae Plantarum
|
2015
|
tom 37
|
nr 03
Inhibitory potencies of 24 α-aminophosphonic acids against barley seeds (Hordeum vulgare L.) metalloaminopeptidase have been determined to evaluate structural requirements of this enzyme. The enzyme was sensitive mostly to the influence of phosphonic acid analogues of phenylalanine and its homologues, thus showing narrow specificity if compared with porcine aminopeptidases M1 and M17 and with Plasmodium aminopeptidase M17.
8

Carrot [Daucus carota L.] allelochemicals as a chemomediators between organisms

51%
Jasicka-Misiak I., Lipok J., Wieczorek P. P., Kafarski P.
Pestycydy
|
2004
|
nr 3-4
9

Transport of amino acids and dipeptides through liquid membranes

45%
Wieczorek P., Skrzypinski W., Bryjak M., Lejczak B., Kafarski P.
Biophysics of Membrane Transport
|
1988
|
tom 09
|
nr 2
10

Odlot na grzybach

45%
Jasicka-Misiak I., Poliwoda A., Mlynarz P., Halama M., Kafarski P.
Wiedza i Życie
|
2012
|
nr 06
11

Profesor Andrzej Zabza

44%
Kafarski P.
Biotechnologia
|
2009
|
nr 1
7-9
12

Improvement of large animal model for studying osteoporosis

39%
Kielbowicz Z., Piatek A., Biezynski J., Skrzypczak P., Chmielewska E., Kafarski P., Kuryszko J.
Bulletin of the Veterinary Institute in Puławy
|
2015
|
tom 59
|
nr 1
The aim of the study was to determine the impact of steroidal medications on the structure and mechanical properties of supporting tissues of sheep under experimentally-induced osteoporosis. A total of 21 sheep were used, divided into three groups: a negative control (KN) (n = 3), a positive control (KP) (n = 3) with ovariectomy, and a steroidal group (KS) (n = 15) with ovariectomy and glucocorticosteroids. All animals were kept on a low protein and mineral diet and had limited physical activity and access to sunlight. Quantitative computed tomography was the examination method. The declines in the examined parameter values in the KS group were more than three times higher than in the KN group. The study suggests that a glucocorticosteroidal therapy accelerates and intensifies processes taking place in the course of osteoporosis. The combination of glucocorticosteroids with ovariectomy, a restrictive diet, limited physical activity, and no access to sunlight leads to a decrease in radiological bone density.
13
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The experimental osteoporosis in sheep - clinical approach

33%
Kielbowicz Z., Piatek A., Biezynski J., Skrzypczak P., Kuropka P., Kuryszko J., Nikodem A., Kafarski P., Pezowicz C.
Polish Journal of Veterinary Sciences
|
2015
|
tom 18
|
nr 3
The implementation of new methods of oseoporotic therapy requires tests on an animal model. One of the best is the sheep, whose numerous advantages over other models are described in the literature. The aim of this study was induction of osteoporosis using steroids and ovariorectomy methods in sheep and description of the change in parameters with regard to healthy sheep. The study was performed on female „merino” breed sheep divided into three groups: Negative control (NC) healthy animals, positive control (PC) ovariorectomised animals and steroid group (SC) where methylprednisolone was implemented. Blood tests, diagnostic arthroscopy, quantitative computed tomography and X-Ray micro-tomography of bone were carried out. Blood tests revealed a decreased level of estrogens, progesterone and increased parathormone and cortisol levels in the SC group. A decrease in bone turnover markers and an increase in bone resorption markers in all groups were also noted. Diagnostic arthroscopy revealed osteoarthrosis in PC and SC groups. Radiological density tests showed a slight decrease in PC and NC groups whereas there was more than a triple decrease in SC. Results obtained from microCT showed quickly developing osteoporosis in the SC group, which is reflected in numerous parameters analysed in this study. The best effects for osteoporosis induction were obtained using ovariorectomised sheep with methylprednisolone injections.
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