The comparative studies were performed on insulin receptors of erythrocytes and liver plasma membranes in fish (tench and carp) and bird (duck). The Scatchard plots indicated the presence of two pools of binding sites both in fish and duck. These pools show inter-species differences in binding ability and the number of receptors. Specific binding of insulin and the binding affinity are higher in duck than in fish.
Torlińska, T., Malendowicz, L. K, Paluszak, J., Koźlik, J., Nowak, M., Nowak, K. W. and Godlewski, J.: The effect of 4-aminopyrazolo (3,4-d) pyrimidine (4-APP) on some parameters of carbohydrate metabolism in the rat. Acta physiol, pol., 1989, 40 (5-6): 530-534. The study was designed to evaluate some parameters of carbohydrate metabolism in the rat as influenced by 4-APP, an adenine analogue. Adult female rats were injected with 1 mg 4-APP /100 g body weight/ day for 3 days. 4-APP evoked a marked enlargement of the liver with lipid droplets accumulation in hepatocytes. This was accompanied by a marked lowering of the liver glycogen content. Within 3 days 4-APP did not change serum glucose, insulin and free fatty acid concentration. Serum glycogenolytic activity studied in an in vitro system showed 7 times as high glucose releasing ability in 4-APP treated rats as that of the serum of control animals. 4-APP resulted also in a marked enlargement of the adrenal medulla and lowered adrenaline and noradrenaline concentrations in the gland. The possibility of an activation of glycogenolysis in the liver of 4-APP treated rats has been discussed.
The aim of this study was to assess the variation in levels of glucose and selected peptide hormones (insulin, leptin and ghrelin) in blood serum of young adults, depending on their nutritional status. Investigations were conducted with the participation of 18 persons, which were divided into three groups characterised by different nutritional status – BMI: <20 kg/m2, 20–25 kg/m2 and >25 kg/m2. Blood samples were collected from each examined person before they have eaten and next blood serum levels were determined for glucose, insulin, leptin, active and total ghrelin. Significant (p<0.05) inter-group differences were shown in leptin concentration, with the highest values of this parameter shown in the group of overweight persons (31.68±23.29 ng/cm3), while the lowest for individuals with BMI<20 kg/m2 (5.81±4.57 ng/cm3). Statistically significant correlations were found between BMI and leptin level (r=0.56, p<0.05), the share of fat mass and levels of insulin (r=0.52, p<0.05) and leptin (r=0.81, p<0.001), as well as the mean skinfolds thickness and the concentration of insulin (r=0.47, p<0.05) and leptin (r=0.63, p<0.01).
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