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Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

100%

Banach T., Zurowski D., Gil K., Krygowska-Wajs A., Marszalek A., Thor P. J.

Journal of Physiology and Pharmacology

2006

tom 57

nr 2

Gastrointestinal dysmotility in Parkinson's disease (PD) has been attributed in part to peripheral neurotoxine action. Our purpose was the evaluation of the salsolinol effect on intramuscular interstitial cells of Cajal (ICC), duodenal myoelectrical activity (DMA) and vagal afferent activity (VAA) in rats with experimental PD. Twenty rats were divided into 2 equal groups. Experimental PD was produced in one group by 3 weeks of the intraperitoneal salsolinol injections (50 mg/kg/day), whereas the 2-nd group served as control. DMA and VAA were recorded in both groups during fasting and stepwise - gastric distension (GD) of 10 ml. Subsequently fragments of duodenum were removed and intramuscular ICC were assessed as c-Kit antigen percentage in the duodenal muscular zone. Analyses of the fasting DMA and VAA recordings didn't reveal differences between the compared groups. During GD increase of DMA dominant frequency (p=0.04) and VAA frequency (p<0.01) was observed in the controls whereas in the salsolinol group both parameters remained unchanged. Image analysis of duodenum revealed decreased c-Kit expression in the salsolinol-injected animals (p=0.05). The results of our study may suggest the direct effect of salsolinol on both ICC and neuronal pathways of gastro-duodenal reflexes.

The effect of transcutaneous nerve stimulation (TENS) on gastric electrical activity

100%

Furgala A., Thor P. J., Kolasinska-Kloch W., Krygowska-Wajs A., Kopp B., Laskiewicz J.

Journal of Physiology and Pharmacology

2001

tom 52

nr 4,1

TENS became widely accepted method of treatment pain syndromes in clinical practice. Lately has been shown that its affects also gastrointestinal tract by releasing NANC neurotransmitter VIP. The aim of this study was to evaluate the effects of TENS on gastric myoelectric activities measured by electrogastrography (EGG). Eighteen healthy men (mean age 23 1.7) were included in the study. Healthy volunteers were divided on 3 groups each 6 persons: with normogastria occurring at 94.5 7% of recording time — group A, with predominant bradygastria (36.6 ± 14%) — group B and with tachygastria (33 14%) — group C. In fasted condition EGG (Synectics, Sweden) was recorded with skin electrodes. TENS 15 min was performed with use of Sinus 5 stimulator (6 Hz, 0.1ms duration, intensities 10 — 20mA, Zimmer, Germany). Stimulating electrodes were placed on non-dominant hand. Results: None of the subjects during TENS reported any side effects or symptoms, during the all studies. In group A in the fasting recordings, after TENS, an decrease of the normal values in the range 2 — 4cpm down to 78.5 ± 21% of recording time (p = 0.03) occurred. The dominant frequency in the bradygastric region increased up to 17.7 7% of the total recording. In group B TENS decreased bradygastria level from 36.6 14% to 20.6 15% (p = 0.02). TENS did not significantly affect tachygastria in group C. Amplitude of the EGG signal after TENS in group B and C increased by 40 and 150% respectively (p < 0.05). Significant decrease of the amplitude was observed in group A (13%). We conclude that TENS by activating centrally mediated somato-visceral reflexes affects gastric electrical activity. Our results suggest that TENS may be useful in treatment of the gastric dysrhythmia.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

2 Krygowska-Wajs A.

2 Thor P. J.

1 Banach T.

1 Furgala A.

1 Gil K.

1 Kolasinska-Kloch W.

1 Kopp B.

1 Laskiewicz J.

1 Marszalek A.

1 Zurowski D.

1 2006

1 2001

Wyniki wyszukiwania

Peripheral mechanisms of intestinal dysmotility in rats with salsolinol induced experimental Parkinson's disease

The effect of transcutaneous nerve stimulation (TENS) on gastric electrical activity