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High density lipoprotein and low density lipoprotein-mediated changes in cultured human skin fibroblasts

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Jozwiak Z., Szosland D., Rozga B.

Cellular and Molecular Biology Letters

1996

tom 01

nr 2

We investigated the effect of native and modified high density lipoprotein (HDL) and low density lipoprotein (LDL) on the viability and the membrane fluidity of normal and diabetic fibroblasts. Under experimental conditions, HDL did not affect the cultured normal cells. Incubation of HDL with diabetic fibroblasts resulted in a negligible decrease in the cell viability and induced an increase in the lipid fluidity at surface of the cell membranes. LDL at the higher concentration reduced the viability both normal and diabetic fibroblasts and also enhanced the fluidity of membrane lipids. The above changes in the fluidity of fibroblast membranes were observed mainly in the presence of native and oxidized lipoproteins and are connected with the differences in the structure of cell membranes and nature of the cytotoxicity of LDL and HDL.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Jozwiak Z.

1 Rozga B.

1 Szosland D.

1 1996

Wyniki wyszukiwania

High density lipoprotein and low density lipoprotein-mediated changes in cultured human skin fibroblasts