Wyniki wyszukiwania

1

Production of DNA strand breaks by PMA in human neutrophils and inhibition by gallic acid

100%

Ignatowicz E., Piechocka P., Gorecka K.

Acta Biochimica Polonica

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2003

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tom 50

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nr Supplement 1

2

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Antitumor and immunomodulatory activity of Inonotus obliquus

100%

Staniszewska J., Szymanski M., Ignatowicz E.

Herba Polonica

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2017

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tom 63

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nr 2

3

Cloudy apple juice modulates the DNA damage and antioxidant status in rats

100%

Ignatowicz E., Kazmierczak Z., Baer-Dubowska W.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

4

Antioxidative activity of flavonoids in stimulated human neutrophils

100%

Zielinska M., Kostrzewa A., Ignatowicz E.

Folia Histochemica et Cytobiologica

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2000

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tom 38

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nr 1

5

The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation

100%

Zielinska M., Kostrzewa A., Ignatowicz E., Budzianowski J.

Acta Biochimica Polonica

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2001

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tom 48

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nr 1

Two natural flavonoids, quercetin and isorhamnetin 3-O-acylglucosides, were examined for their inhibitory influence on the in vitro production and release of reactive oxygen species in polymorphonuclear neutrophils (PMNs). The generation of superoxide radical, hydrogen peroxide and hypochlorous acid were measured by, respectively, cytochrome c reduction, dichlorofluorescin oxidation and taurine chlorination. Membrane lipid oxidation was studied by the thiobarbituric acid method in mouse spleen microsomes. The addition of flavonoids at the concentration range 1-100 uM inhibited PMNs oxidative metabolism and lipid peroxidation in a dose-dependent manner. The results suggest that these flavonoids suppress the oxidative burst of PMNs and protect membranes against lipid peroxidation.

6

Evaluation of apoptotic activity of new condensed pyrazole derivatives

88%

Toton E., Ignatowicz E., Bernard M. K., Kujawski J., Rybczynska M.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 1

7

Effects of naturally occurring plant phenols on production of reactive oxygen species and DNA damage induced by tumour promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) in mouse epidermis

88%

Ignatowicz E., Zielinska-Przyjemska M., Szaefer H., Sobierajska H., Baer-Dubowska W.

Herba Polonica

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2012

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tom 58

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nr 4

Naturally occurring phenolics: protocatechuic, chlorogenic, tannic acids and trihydroxystilbene and resveratrol were shown to inhibit multistage carcinogenesis in animal models, including mouse epidermis. Treatment of mouse skin with tumor promoter 12-Otetradecanoyl phorbol-13-acetate (TPA) may induce ROS production in keratinocytes and skin infiltrating leukocytes. In our study, the effect of these phenolics on intracellular ROS production and DNA damage was examined. ROS were analysed by flow cytometry, while DNA damage by comet assay. Following treatment with TPA (6.8 nmol/mouse) two subpopulations of epidermal cells were identified. Pretreatment of mice with 16 mmol of phenolics decreased ROS production in both subpopulations. The most efficient inhibitors of ROS in whole population of keratinocytes were chlorogenic acid and resveratrol. Tannic acid reduced the most DNA damage induced by TPA treatment. These results suggest that anti-promotional effects of these two plant phenols might be partially explained by the inhibition of TPA-induced inflammation.

8

Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils

88%

Ignatowicz E., Szaefer H., Zielinska M., Korczowska I., Fenrych W.

Acta Biochimica Polonica

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1997

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tom 44

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nr 1

Silybin and silydianin exerted an inhibitory effect on superoxide radical production, peak chemiluminescence and hydrogen peroxide production in human polymorphonuclear neutrophils activated with opsonized zymosan.

Ograniczanie wyników

Production of DNA strand breaks by PMA in human neutrophils and inhibition by gallic acid

Antitumor and immunomodulatory activity of Inonotus obliquus

Cloudy apple juice modulates the DNA damage and antioxidant status in rats

Antioxidative activity of flavonoids in stimulated human neutrophils

The flavonoids, quercetin and isorhamnetin 3-O-acylglucosides diminish neutrophil oxidative metabolism and lipid peroxidation

Evaluation of apoptotic activity of new condensed pyrazole derivatives

Effects of naturally occurring plant phenols on production of reactive oxygen species and DNA damage induced by tumour promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) in mouse epidermis

Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils