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1

Oncofetal antigen/immature laminin receptor protein in pregnancy and cancer

100%
Barsoum A. L., Schwarzenberger P. O.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 3
The 37-kDa immature laminin receptor protein (iLRP) is a speciesconserved, universal immunogenic protein that is expressed in all thus-far examined embryonic and early fetal cells of inbred and outbred rodents. It has also been identified in human concepti. It is altered through normal maturation processes to become a non-immunogenic 67-kDa dimeric mature laminin receptor protein (mLRP) in mid-to late gestation in the mammalian fetus. This antigen ceases to be expressed as an active autoimmunogen in the full-term fetus and in the normal differentiating tissues and organs of the neonate or adult organism, apparently due to dimerization, but it is re-expressed as an immunogenic monomer in tumor cells. In this review, we highlight the known mechanisms of immune responses with particular emphasis on the possible role of the 37-kDa oncofetal antigen/immature laminin receptor (OFA/iLRP) in both pregnancy and cancer.
2

37kDa oncofetal antigen is an autoimmunogenic homologue of the 37kDa laminin receptor precursor

80%
Barsoum A. L., Rohrer J. W., Coggin J. H.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 2
The laminin receptor precursor (LRP) has been the center of intense controversy and interest for over a decade. Chief among these controversies is the putative multifunctional aspect of this molecule: as a ribosomal-associated protein (p40) and/or as the precursor for the 67kDa high-affinity laminin receptor (67LR), neither of which have been definitively established. Other controversies include the presence of more than one 67kDa laminin receptor protein. However, interest in the molecule is sustained because of its vital function in the cell as a component of the translational machinery and due to its constant up-regulation in cancer cells with the invasive and metastatic phenotype and in association with poor prognosis. Recently, while studying the autoimmunogenicity of a species conserved 37-44 kDa oncofetal antigen (37kDa OFA), the authors of this paper, using amino acid sequencing of isolated OFA-peptides, cDNA cloning and sequencing and antigens-antibodies cross reactivity as well as antigens-T cell recognition reactions, identified the 37kDa OFA as precursor or immature laminin receptor protein.
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