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Alweokokoza u ludzi narastajacym problemem w Polsce i w Europie

100%

Knap J., Czyrznikowska A.

Wiadomości Parazytologiczne

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2010

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tom 56

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nr 3

213

2

Ognisko gorączki "Q" w zakładzie przemysłu skórzanego

81%

Pejsak Z., Anusz Z., Knap J., Ziemka J.

Medycyna Weterynaryjna

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1988

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tom 44

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nr 06

Описали очаг Ку лихорадки среди работников предприятия кожевенной промышленности. Источником инфекции было кожаное сыре, вероятно шкуры с овец и скота, происходящие из Олыптыньского и других воеводств, а также козлиные шкуры из Монголии. Среди 305 исследованных работников противотела анти С. burneti отметили у 57 лиц (18,7%), в том у 34 лиц (11,1%) в титре выше 1:8 и у 16 лиц (5,2%) в титре 1:16. Противотела в реакции связывания комплемента отметили у 22 лиц: в титре 1:4 у 18 лиц, 1:8 у 2 и 1:16 у 2. В реакции микроагглютинации наличие противотел показали у 40 лиц: титры 1:4 у 8 лиц 1:8 у 18, 1:16 у 14. Более чувствительной оказалась реакция микроагглютинации. Эпидемиологически-клинические и серологические исследования показали необходимость госпитализации 5 лиц, клиническое описание которых представлено в работе. Кажется, что существует потенциальная угроза загрязнения окружающей среды неочищенными и недезинфицироваиными сточными водами, содержащими С. burneti из предприятий кожевенной промышленности. Ветслужба должна укроплять сотрудничество с противоэпидемической службой.

3

Lessons learned from 2001-2021 - from the bioterrorism to the pandemic era

81%

Michalski A., Knap J., Bielawska-Drozd A., Bartoszcze M.

Annals of Agricultural and Environmental Medicine

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2022

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tom 29

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nr 1

4

Research on prevention and treatment of hemorrhagic fevers

71%

Joniec J., Kolodziej M., Bartoszcze M., Kocik J., Knap J.

Annals of Agricultural and Environmental Medicine

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2012

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tom 19

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nr 2

Viral hemorrhagic fevers are severe zoonotic diseases caused by RNA-viruses classified into 4 families: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. They are present on all continents except Antarctica, their person-to-person spread is easy, and there is a high risk of them being used as weapon by bioterrorists. So far, efforts to develop effective drugs against these viruses have failed, and typical therapy usually relies on symptomatic treatment. Search for substances that could effectively inhibit this type of infections is now a priority. The presented paper gives an overview of different approaches used in combating the viral hemorrhagic fevers. Researchers look for safe antiviral agents with appropriate properties among natural sources, such as various types of herbs plants, algae, or essential oils obtained from trees, as well as investigate the use of various synthetic substances. The aim is to broaden the pool of available antiviral drugs that could replace hitherto applied medicines such as ribavirin, which is not always sufficiently effective and may have side-effects. The scientists focus not only on combating the diseases, but also on their prevention. For this purpose, recombinant vaccines or various types of immunomodulators may serve as a useful tools. Results of the latest studies are promising and encourage further work which may eventually lead to the solution of the urgent problem of hemorrhagic fevers.

5

Research on substances with activity against orthopoxviruses

61%

Kolodziej M., Joniec J., Bartoszcze M., Gryko R., Kocik J., Knap J.

Annals of Agricultural and Environmental Medicine

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2013

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tom 20

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nr 1

Although smallpox was eradicated over 30 years ago, the disease remains a major threat. High mortality, high infectivity and low resistance of the contemporary population make the smallpox virus very attractive to terrorists. The possible presence of illegal stocks of the virus or risk of deliberate genetic modifications cause serious concerns among experts. Hence, it is reasonable to seek effective drugs that could be used in case of smallpox outbreak. This paper reviews studies on compounds with proven in vitro or in vivo antipoxviruses potential, which show various mechanisms of action. Nucleoside analogues, such as cidofovir, can inhibit virus replication. Cidofovir derivatives are developed to improve the bioavailability of the drug. Among the nucleoside analogues under current investigation are: ANO (adenozine N1-oxide) and its derivatives, N-methanocarbothymidine [(N)-MCT], or derivatitives of aciklovir, peninclovir and brivudin. Recently, ST-246 – which effectively inhibits infection by limiting release of progeny virions – has become an object of attention. It has been also been demonstrated that compounds such as: nigericin, aptamers and peptides may have antiviral potential. An interesting strategy to fight infections was presented in experiments aimed at defining the role of individual genes (E3L, K3L or C6L) in the pathogenesis, and looking for their potential blockers. Additionally, among substances considered to be effective in the treatment of smallpox cases, there are factors that can block viral inhibitors of the human complement system, epidermal growth factor inhibitors or immunomodulators. Further studies on compounds with activity against poxviruses are necessary in order to broaden the pool of available means that could be used in the case of a new outbreak of smallpox.

6

Limfocytarne zapalenie splotu naczyniówkowego i opon mózgowych, LCM (Lymphocytic choriomeningitis)

61%

Swieboda P., Filip R., Knap J., Galinska E. M., Zukiewicz‑Sobczak W., Szwiec K.

Medycyna Ogólna i Nauki o Zdrowiu

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2012

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tom 18(47)

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nr 4

7

Sytuacja epizootiologiczna-epidemiologiczna goraczki Q u bydla i ludzi w regionie Zulaw

51%

Anusz Z., Rehacek J., Knap J., Krauss H., Ciecierski H., Platt-Samoraj A., Wodecki W., Lewicki P.

Acta Academiae Agriculturae ac Technicae Olstenensis. Veterinaria

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1992

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tom 20

35-45

Gorączka Q stanowi ważny problem epizootiologiczno-epidemiologiczny u ludzi i bydła w regionie Żuław. Badania przeprowadzone w 9 Zakładach Rolnych wykazały obecność przeciwciał anty C. burnetii u bydła w 6 fermach hodowlanych: w ZR „Janów" — 92% badanych zwierząt, ZR „Stegna Gdańska" — 42%, ZR „Marynów" — 15%, ZR „Nowinki" — 10%, ZR „Tuja" — 6% i ZR „Orłowo" — 4%. W fermie „Janów" wykryto u 11 pracowników (14%) przeciwciała anty C. burnetii. Hospitalizowano 3 osoby. Szczególnie wysoki odsetek przeciwciał wykazano odczynem ELISA u ludzi w 5 fermach. W diagnostyce różnicowej chorób odzwierzęcych u ludzi i zwierząt zamieszkujących ten region lekarze winni uwzględnić gorączkę Q. W ZR „Janów" stwierdzono wysoki odsetek przeciwciał anty C. burnetii u gryzoni (myszy domowe) żyjących w magazynach paszowych (80%), które stanowią niebezpieczny rezerwuar i źródło zakażenia gorączką Q. Najmniej przydatny w diagnostyce okazał się odczyn wiązania dopełniacza, najczulszy — test ELISA, a następnie odczyn immunofluorescencyjny i odczyn mikroaglutynacji.

8

Bacillus anthracis infections – new possibilities of treatment

51%

Zakowska D., Bartoszcze M., Niemcewicz M., Bielawska-Drozd A., Knap J., Cieslik P., Chomiczewski K., Kocik J.

Annals of Agricultural and Environmental Medicine

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2015

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tom 22

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nr 2

9

Usefulness of PCR method for detection of Leishmania in Poland

42%

Myjak P., Szulta J., de Almeida M. E., da Silva A. J., Steurer F., Lass A., Pietkiewicz H., Nahorski W. L., Goljan J., Knap J., Szostakowska B.

Polish Journal of Microbiology

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2009

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tom 58

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nr 3

219-222

Leishmania parasites are the etiological agents of leishmaniosis, with severe course and often fatal prognosis, and the global number of cases has increased in recent decades. The gold standards for the diagnosis of leishmaniosis are microscopic examinations and culture in vitro of the different clinical specimens. The sensitivity of these methods is insufficient. Recent development in specific and sensitive molecular methods (PCR) allows for detection as well as identification of the parasite species (subspecies). The aim of the study was to estimate the usefulness of molecular methods (PCR) for detection of Leishmania species and consequently for the implementation of such methods in routine diagnostics of leishmaniosis in Polish patients returning from endemic areas of the disease. In our investigations we used 54 known Leishmania positive DNA templates (from culture and clinical specimens) received from the CDC (Atlanta, GA, USA). Moreover, 25 samples of bone marrow, blood or other tissues obtained from 18 Polish individuals suspected of leishmaniosis were also examined. In PCR we used two pairs of primers specific to the conserved region of Leishmania kinetoplast DNA (kDNA) minicircle (13A/13B and F/R). Using these primers we obtained amplicons in all DNA templates from the CDC and in three Polish patients suspected for Leishmania infection. In one sample from among these cases we also obtained positive results with DNA isolated from a blood specimen which was previously negative in microscopic examinations.

Ograniczanie wyników

Alweokokoza u ludzi narastajacym problemem w Polsce i w Europie

Ognisko gorączki "Q" w zakładzie przemysłu skórzanego

Lessons learned from 2001-2021 - from the bioterrorism to the pandemic era

Research on prevention and treatment of hemorrhagic fevers

Research on substances with activity against orthopoxviruses

Limfocytarne zapalenie splotu naczyniówkowego i opon mózgowych, LCM (Lymphocytic choriomeningitis)

Sytuacja epizootiologiczna-epidemiologiczna goraczki Q u bydla i ludzi w regionie Zulaw

Bacillus anthracis infections – new possibilities of treatment

Usefulness of PCR method for detection of Leishmania in Poland