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1

Zawartość wybranych fosfolipidów w łożysku i płynie owodniowym w prawidłowej ciąży

100%
Siemianowicz K., Stajszczyk M., Bula T.
Diagnostyka Laboratoryjna i Wiadomości PTDL
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1994
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tom 30
|
nr 4
2

Nanosilver - does it have only one face?

100%
Likus W., Bajor G., Siemianowicz K.
Acta Biochimica Polonica
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2013
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tom 60
|
nr 4
 Silver nanoparticles (NPs) have at least one dimension of a particle smaller than 100 nm and contain 20-15,000 silver atoms. Due to its antibacterial activity nanosilver (NS) is used for medical purposes. NS particles can be obtained by various methods. Potentially, the best method of the NS synthesis for medical purposes is based on a brief flow of electric current between two silver electrodes placed in deionized water. It is accepted that the major antibacterial effect of silver is its partial oxidation and releasing silver ions, which interact with thiol groups of peptidoglicans of bacterial cell wall, and proteins of the cell membrane causing cell lysis. Silver ions can also bind to bacterial DNA preventing its replication and stopping synthesis of bacterial proteins. The rise in exposure to silver NPs has spurred interest into their toxicology. NS undergoes a set of biochemical transformations including accelerated oxidative dissolution in gastric acid, binding to thiol groups of serum and tissue proteins, exchange between thiol groups, sulfides and selenides, binding to selenoproroteins and photoreduction in skin to zerovalent metallic silver. Animal studies have shown that exposure to NS may lead to liver and spleen damage. NS can also stimulate an increased secretion of proinflammatory cytokines by monocytes. As a spectrum of NS applications is still growing, the complex evaluation of a safety of its use becomes an important task. This requires an elucidation of not only the influence of NS on human cells and organism, but also its biotransformation in organism and in environment.
3

Effects of salmon calcitonin on aorta connective tissue in elastin-derived peptides (EDP) induced experimental atherosclerosis

100%
Siemianowicz K., Gminski J., Goss M., Francuz T.
Diagnostyka Laboratoryjna
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2006
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tom 42
|
nr 3
4

The influence of nutrition on the plasma phospholipid profile in infants

100%
Siemianowicz K., Wojakowski W., Ulfig-Maslanka R.
Żywienie Człowieka i Metabolizm
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1997
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tom 24
|
nr 1
23-28
In our research we evaluated possible influence of various formulae used for infant feeding as well as breast feeding on the plasma phospholipid profile. It was found out that the method of infant feeding does influence the plasma phospholipid profile.
5

Glutathione peroxidase, superoxide dismutase, tumor necrosis factor alpha, C-reactive protein and vascular cell adhesion molecule 1 are markers of metabolic syndrome

88%
Francuz T., Gminski J., Siemianowicz K., Posielezna B., Wojcik A.
Acta Biochimica Polonica
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2006
|
tom 53
|
nr Supplement 1
6

Ocena wybranych parametrow biochemicznych w surowicy krwi i tkankach szczurow narazonych na fungicyd aldimorf. Cz.IV. Wplyw aldimorfu na aktywnosc enzymow antyoksydacyjnych i zawartosc dialdehydu malonowego we frakcji cytozolowej watroby i nerki szczura

88%
Goss M., Drozdz M., Siemianowicz K., Weglarz L., Gminski J.
Acta Poloniae Toxicologica
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1993
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tom 01
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nr 2
177-185
7

Ocena wybranych parametrow biochemicznych w surowicy krwi i tkankach szczurow narazonych na fungicyd aldimorf. Cz.II. Wplyw aldimorfu na aktywnosc wybranych enzymow w surowicy krwi szczura

88%
Goss M., Siemianowicz K., Kobes S., Knapek R., Gminski J.
Acta Poloniae Toxicologica
|
1993
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tom 01
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nr 2
165-171
8

Plasma homocysteine concentration in patients with small cell and non-small cell lung cancer

88%
Siemianowicz K., Gminski J., Danch A., Machalski M., Magiera-Molendowska H.
Diagnostyka Laboratoryjna
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2004
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tom 40
|
nr 1
9

The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase -1, -2, -9 and tissue inhibitor of metalloproteinases -1, -2, -3 expression in human retinal pigment epithelial cells

88%
Dorecka M., Francuz T., Garczorz W., Siemianowicz K., Romaniuk W.
Acta Biochimica Polonica
|
2014
|
tom 61
|
nr 2
10

Ocena wybranych parametrow biochemicznych w surowicy krwi i tkankach szczurow narazonych na fungicyd aldimorf. Cz.I.Wplyw aldimorfu na parametry gospodarki lipidowej w surowicy krwi szczura

88%
Goss M., Siemianowicz K., Knapek R., Gminski J., Kobes S.
Acta Poloniae Toxicologica
|
1993
|
tom 01
|
nr 2
159-164
11

Ocena wybranych parametrow biochemicznych w surowicy krwi i tkankach szczurow narazonych na fungicyd aldimorf. Cz.III. Wplyw aldimorfu na stezenie hydroksyproliny i hydroksylizyny w surowicy krwi

76%
Goss M., Kotrys-Puchalska E., Wedrychowska A., Drozdz M., Gminski J., Siemianowicz K.
Acta Poloniae Toxicologica
|
1993
|
tom 01
|
nr 2
172-176
12

Influence of elastin-derived peptides, glucose, LDL and oxLDL on nitric oxide synthase expression in human umbilical artery endothelial cells

76%
Garczorz W., Francuz T., Gminski J., Likus W., Siemianowicz K., Jurczak T., Strzalka-Mrozik B.
Acta Biochimica Polonica
|
2011
|
tom 58
|
nr 3
Endothelial dysfunction plays an important role in the development of atherosclerosis. Elastin-derived peptides (EDP), hyperglycemia, hypercholesterolemia and oxidized LDL have a proven proatherosclerotic potential. Nitric oxide generated by endothelial nitric oxide synthase (eNOS; EC 1.14.13.39) is an important vasorelaxant. Here we studied the influence of those proatherosclerotic factors on eNOS gene and protein expression in artery-derived endothelial cells. Human umbilical artery endothelial cells (HUAEC) were incubated with or without: glucose (270 mg/dl), LDL (200 mg/dl), oxidized LDL (oxLDL 25 mg/dl) or κ-elastin (0.5 and 2.5 µg/ml). Gene expression was assessed by real time RT-PCR, whilst the eNOS protein by ELISA. In cells incubated with 2.5 µg/ml of κ-elastin, a 31 % increase of eNOS mRNA expression was observed, but the protein level remained unchanged. OxLDL, LDL and glucose decreased the eNOS protein level by 74 %, 37 % and 29 %, respectively. OxLDL decreased eNOS mRNA by 42 %. LDL non-significantly decreased eNOS mRNA expression. An elevated glucose level did not affect the eNOS mRNA expression. Hyperglycemia and an elevated level of LDL, particularly oxLDL, decreased the level of eNOS protein in endothelial cells. As κ-elastin did not decrease the expression of eNOS gene in HUAEC, the proatherogenic properties of elastin-derived peptides are unlikely to be due to their influence on eNOS.
13

Bacterial infections and osteoclastogenesis regulators in men and women with cholesteatoma

64%
Likus W., Siemianowicz K., Markowski J., Wiaderkiewicz J., Kostrzab-Zdebel A., Jura-Szoltys E., Dziubdziela W., Wiaderkiewicz R., Los M. J.
Archivum Immunologiae et Therapiae Experimentalis
|
2016
|
tom 64
|
nr 3
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