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Inflammatory bowel disease (IBD), which includes mainly ulcerative colitis (UC) and Crohn’s disease (Lesniowski-Crohn’s, ChL-C, CD), is a chronic and recurrent inflammatory condition of the gastrointestinal tract with multifactorial causes. Both types of IBD are characterized by chronic inflammation with periods of remission and exacerbation. An increasing number of studies have recently shown that chronic inflammation plays an important role in the carcinogenesis of colorectal cancer (CRC), generating suitable microenvironments for the formation and progression of the disease. The main factors are chronic inflammation as well as the scope and duration of the disease. The pro-inflammatory interleukins IL-13, IL-8 and TNF-α play an important role in tumorigenesis. It is further emphasized that reactive oxygen species (ROS) and reactive nitrogen species produced by inflammatory cells may interact with key genes involved in carcinogenic pathways, such as TP53. Carcinogenesis in IBD involves proteins determined by the genes DLG5, OCTN and NOD2. Immunosuppressive drugs, such as thiopurines and methotrexate, may play a role in extra-intestinal tumour development by impairing the immune system and surveillance of tumour cells or by inducing DNA damage. Recognition of neoplastic changes associated with IBD is difficult due to the heterogeneity of the endoscopic image and variation in the diagnosis depending on the observer. Therefore surveillance of IBD patients by a multidisciplinary team is essential for early detection of the neoplastic process.
Determination of the exact time of death of a human being or animal is extremely important for investigations conducted by law enforcement agencies. The development of a single model of tests and analysis of the site of the incident would be a breakthrough for forensic and veterinary medicine in estimating the exact time of death. Microorganisms play a key role in the putrefaction process. Each stage of decomposition is characterized by the colonization of tissues by different microbial taxa. The objective of the study was to determine the suitability of microbiological tests for establishing the time of death, using the example of the gastrocnemius muscle in a dog (German Shepherd). The results of the study showed that sporulating aerobic bacteria of the species Bacillus cereus, as well as anaerobic bacteria, played a major role in the putrefaction process. No E. coli were found in the material. The first bacterial colonies belonging to the Bacillus cereus group were observed on the 7th day after the death of the animal, and their quantitative growth persisted throughout the study period, i.e. until the 21st day after death. The analysis carried out in this study shows that Bacillus cereus bacteria appear much sooner than anaerobic bacteria.
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