Wyniki wyszukiwania

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Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice

100%

Manda K., Anzai K., Kumari S., Bhatia A. L.

Acta Neurobiologiae Experimentalis

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2007

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tom 67

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nr 1

Oxidative stress has been implicated in cognitive impairment in both experimental animals and humans. This implication has led to the notion that antioxidant defence mechanisms in the brain are not sufficient to prevent oxidative damage, and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. The present study, therefore, aimed to investigate the protective effect of melatonin against radiation-induced impairment in the learning ability of mice. Twenty days oral administration of melatonin (0.1 mg/kg b.w.), followed by an acute exposure to ¡-radiation (6 Gy), inhibited the radiation-induced decline in learning ability. Biochemical estimation of brain protein carbonyls, malondialdehide (MDA) and reduced glutathione (GSH) in these mice indicated that radiation-induced augmentation of protein oxidation and lipid peroxidation had been significantly ameliorated in melatonin treated, irradiated mice. Radiation-induced deficit of glutathione was also normalized by melatonin administration, as there was no statistical difference from normal at P<0.001. Results indicate the antioxidative as well as neuroprotective properties of melatonin against the radiation. These findings support results showing melatonin as a free radical scavenger.

2

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Indo-French comprehensive bilateral cooperation: A roadmap to Indo-Pacific park partnership and beyond

100%

Bharti M. S., Kumari S., Bharti S. S.

Economic and Regional Studies

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2022

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tom 15

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nr 3

3

Cytogenetic diversity of Elsholtzia ciliata Benth. (Lamiaceae) from Kashmir Himalaya

100%

Malik R. A., Gupta R. C., Kumari S.

Acta Biologica Cracoviensia. Series Botanica

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2012

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tom 54

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nr 1

Our cytomorphological study of various populations of Elsholtzia ciliata (Lamiaceae) collected from high-altitude sites of Kashmir Himalaya revealed two euploid cytomorphotypes, diploid (n=8) and tetraploid (n=16), growing sympatrically but inhabiting two different habitats. This is the first report of tetraploid (4×) E. ciliata from the Indian subcontinent. We found the course of meiois to be normal in diploids, but tetraploid individuals showed chromosome and meiotic irregularities: cytomixis at early prophase I, stickiness at metaphase I, and chromosome bridges at anaphase I. In tetraploids, 23 of the 26 pollen mother cells observed at metaphase I showed 0–6 quadrivalents, suggesting that the tetraploid is a segmental allopolyploid. Microsporogenesis was also abnormal in tetraploids, showing the formation of triads. All these anomalies are conducive to lower reproductive potential (40.70%) in tetraploids than in diploids (90.50%). Significant morphological differences between the two cytotypes are presented.

4

Chromosome numbers and basic chromosome numbers in monocotyledonous genera of the Western Himalayas (India)

100%

Kaur H., Mubarik N., Kumari S., Gupta R. C.

Acta Biologica Cracoviensia. Series Botanica

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2014

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tom 56

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nr 2

5

Meiotic studies in some members of Caryophyllaceae Juss. from the Western Himalayas

88%

Jeelani S. M., Rani S., Kumar S., Kumari S., Gupta R. C.

Acta Biologica Cracoviensia. Series Botanica

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2011

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tom 53

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nr 1

The paper reports meiotic studies on 50 populations comprising 12 species belonging to 5 genera of Caryophyllaceae from the Western Himalayas. The chromosome numbers in Arenaria kashmirica (n=20), Silene conoidea (n=20), S. edgeworthii (n=12 and n=24), S. moorcroftiana (n=24), S. nepalensis (n=12), Stellaria media (n=13), S. monosperma (n=13) and S. semivestita (n=13) are reported for the first time. The chromosome numbers in Lychnis coronaria (n=12) and Silene vulgaris (n=24) are given for the first time from India, along with Gypsophilla ceratioides (n=15) from the Western Himalayas. The course of meiosis varies from normal to abnormal in different populations of Silene conoidea, S. edgeworthii, S. vulgaris, Stellaria media, S. monosperma and S. semivestita. The course of meiosis was abnormal in all studied populations of Lychnis coronaria. Abnormal microsporogenesis (cytomixis, chromosomal stickiness, unoriented bivalents, formation of laggards and bridges) led to reduced pollen fertility and differences in pollen grain size.

6

Mitigation of As toxicity in wheat by exogenous application of hydroxamate siderophore of Aspergillus origin

76%

Kumari S., Khan A., Singh P., Dwivedi S. K., Ojha K. K., Srivastava A.

Acta Physiologiae Plantarum

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2019

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tom 41

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nr 07

Siderophores are secondary metabolites having molecular weight less than 10 KD. They are specifically meant for chelation of ferric ions. They also tend to chelate metals under heavy metal stress, thus reducing their toxic effects. In the current study, experiments have been conducted on wheat plants to analyse siderophore’s ability to counteract the adverse impact of arsenic (As) toxicity on physiology of plant seedlings along with biochemical response. As toxicity has been observed to adversely affect the lengths of root and shoot, chlorophyll and carotenoid contents, and activities of various antioxidative enzymes. The present study revealed that the application of hydroxamate-type siderophore isolated from Aspergillus nidulans under toxic condition significantly recovered the growth and helped in amending the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) of wheat genotype (NW1014). At the same time, injury caused by lipid peroxidation was significantly reduced. In silico studies revealed better binding affinity of ferricrocin–arsenate complex leading to thermodynamically stable complex. Encouraging results of As containment by organic biomolecule-siderophore can lead to an emerging bioremediation mechanism brimming with opportunities for agricultural field and environmental clean-up.

7

Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite

76%

Sindhu K. J., Kureel A. K., Saini S., Kumari S., Verma P., Rai A. K.

Acta Parasitologica

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2018

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tom 63

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nr 1

Ograniczanie wyników

Melatonin attenuates radiation-induced learning deficit and brain oxidative stress in mice

Indo-French comprehensive bilateral cooperation: A roadmap to Indo-Pacific park partnership and beyond

Cytogenetic diversity of Elsholtzia ciliata Benth. (Lamiaceae) from Kashmir Himalaya

Chromosome numbers and basic chromosome numbers in monocotyledonous genera of the Western Himalayas (India)

Meiotic studies in some members of Caryophyllaceae Juss. from the Western Himalayas

Mitigation of As toxicity in wheat by exogenous application of hydroxamate siderophore of Aspergillus origin

Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite