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Kliniczne znaczenie związku mikrobiota - leki

100%

Skonieczna-Zydecka K., Loniewska B.

Wszechświat

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2023

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tom 124

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nr 01-03

2

Mleko ludzkie - tkanka obronna i immunomodulujaca

81%

Pawlus B., Loniewska B., Kordek A.

Żywienie Człowieka i Metabolizm

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2004

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tom 31

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nr 4

363-368

3

Czy pokarm matki wczesniaka jest mniej wartosciowy?

81%

Pawlus B., Kordek A., Loniewska B.

Żywienie Człowieka i Metabolizm

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2005

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tom 32

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nr 4

317-324

4

Congenital candidiasis as a subject of research in medicine and human ecology

61%

Skoczylas M. M., Walat A., Kordek A., Loniewska B., Rudnicki J., Maleszka R., Torbe A.

Annals of Parasitology

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2014

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tom 60

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nr 3

Congenital candidiasis is a severe complication of candidal vulvovaginitis. It occurs in two forms, congenital mucocutaneous candidiasis and congenital systemic candidiasis. Also newborns are in age group the most vulnerable to invasive candidiasis. Congenital candidiasis should be considered as an interdisciplinary problem including maternal and fetal condition (including antibiotic therapy during pregnancy), birth age and rare genetic predispositions as severe combined immunodeficiency or neutrophil-specific granule deficiency. Environmental factors are no less important to investigate in diagnosing, treatment and prevention. External factors (e.g., food) and microenvironment of human organism (microflora of the mouth, intestine and genitalia) are important for solving clinical problems connected to congenital candidiasis. Physician knowledge about microorganisms in a specific compartments of the microenvironment of human organism and in the course of defined disorders of homeostasis makes it easier to predict the course of the disease and allows the development of procedures that can be extremely helpful in individualized diagnostic and therapeutic process.

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An age-related decrease in factor V Leiden frequency among Polish subjects

51%

Adler G., Parczewski M., Czerska E., Loniewska B., Kaczmarczyk M., Gumprecht J., Grzeszczak W., Szybinska A., Mossakowska M., Ciechanowicz A.

Journal of Applied Genetics

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2010

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tom 51

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nr 3

Factor V Leiden (G1691A FV mutation) is a widely acknowledged risk factor of deep vein thrombosis, including pulmonary embolism as the most serious complication. However, its high prevalence of ~5% in the Caucasian population might be related to an unknown evolutionary advantage. It might exert a beneficial effect on the carrier, e.g. protecting women from excessive bleeding during labour or allowing increased survival in severe sepsis or with other inflammatory diseases. The aim of our study was to verify or contradict the hypothesis of a favourable association between the A allele (A1691) and longevity in the Polish population. For this purpose, the G1691A mutation was analyzed by PCR-RFLP in 1016 Poles: 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (age ≥ 95 years: 343 women and 89 men). Frequencies of G1691A carriers and the A1691 allele in long-lived individuals (0.2% and 0.1%, respectively) were significantly lower than in neonates (4.2% and 2.2%, respectively) and adults (3.3% and 1.6%). The frequency of the G1691A factor V Leiden mutation decreased with age, which indicates a shorter survival time among A1691 allele carriers in the Polish population.

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Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection

51%

Parczewski M., Leszczyszyn-Pynka M., Kaczmarczyk M., Adler G., Binczak-Kuleta A., Loniewska B., Boron-Kaczmarska A., Ciechanowicz A.

Journal of Applied Genetics

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2009

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tom 50

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nr 2

159-166

Genetic susceptibility to HIV infection was previously proven to be influenced by some chemokine receptor polymorphisms clustering on chromosome 3p21. Here the influence of 5 genetic variants was studied: Δ32 CCR5, G(-2459)A CCR5, G190A CCR2, G744A CX3CR1 and C838T CX3CR1. They were screened in a cohort of 168 HIV-1 positive adults [HIV(+) group] and 151 newborns [control group] from northwestern Poland. PCR-RFLP was performed to screen for the variants (except for Δ32 CCR5 polymorphism, where PCR fragment size was sufficient to identify the alleles) and then electrophoresed on agarose gel to determine fragment size. Distribution of genotypes and alleles was not significantly different between the groups except for the CCR5 polymorphisms, with the Δ32 allele and the (-2459)A CCR5 allele more frequent among neonates than in the HIV(+) group. No Δ32/Δ32 homozygotes were found in the HIV(+) group, but 16.1% were Δ32/wt heterozygotes. In the control group, 1.3% were Δ32/Δ32 homozygotes and 26.0% were Δ32/wt heterozygotes. Linkage between the chemokine polymorphisms was calculated using the most informative loci for haplotype reconstruction. Haplotypes containing Δ32 CCR5,190G CCR2 and 744A CX3CR1 were found to be significantly more common in the control group. This suggests an association between these haplotypes and resistance to HIV-1 infection.

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CYP17 and CYP19 genetic variants are not associated with age at natural menopause in Polish women

51%

Rumianowski B., Adler G., Safranow K., Brodowska A., Karakiewicz B., Sluczanowska-Glabowska S., Loniewska B., Piasecka M., Ciechanowicz A., Laszczynska M.

Reproductive Biology

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2012

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tom 12

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nr 4

8

The association of ADA 2 allen of the adenosine deaminase gene with the susceptibility to coronary artery disease

42%

Safranow K., Rzeuski R., Biczak-Kuleta A., Czyzycka E., Skowronek J., Jakubowska K., Olszewska M., Wojtarowicz A., Loniewska B., Ciechanowicz A., Kornacwewicz-Jach Z., Chlubek D.

Acta Biochimica Polonica

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2006

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tom 53

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nr Supplement 1

9

AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases

42%

Safranow K., Suchy J., Jakubowska K., Olszewska M., Binczak-Kuleta A., Kurzawski G., Rzeuski R., Czyzycka E., Loniewska B., Kornacewicz-Jach Z., Ciechanowicz A., Chlubek D.

Journal of Applied Genetics

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2011

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tom 52

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nr 1

Previous studies showed an association of the common functional polymorphism (C34T, Gln12Stop) in the adenosine monophosphate deaminase-1 (AMPD1) gene with survival in heart failure (HF) and/or coronary artery disease (CAD). The aim of the study was to search for other mutations in selected regions of the AMPD1 gene in Polish CAD and HF patients, and to analyze their associations with obesity and diabetes. Exons 2, 3, 5, and 7 of AMPD1 were scanned for mutations in 97 patients with CAD without HF (CAD+ HF−), 104 patients with HF (HF+), and 200 newborns from North-Western Poland using denaturing high-performance liquid chromatography (DHPLC), polymerase chain reaction–restriction fragment length polymorphism (PCRRFLP), and direct sequencing. Frequencies of AMPD1 C34T mutation, as well as novel A99G, G512A, IVS4-6delT, and C784T sequence alterations, were similar in the three groups, but 860T mutated allele was less frequent in the combined CAD+ HF− and HF+ groups than in the controls (1.7% vs. 4.3%, p=0.040). Heterozygous 34CT genotype was associated with lower (odds ratio [OR]=0.32, 95% confidence interval [CI]=0.13–0.81) and 860AT with higher (OR=13.7, 95%CI= 1.6–118) prevalence of diabetes or hyperglycemia in relation to wild-type homozygotes. Abdominal obesity was more frequent in 860AT patients than in wild-type homozygotes and 34CT heterozygotes (86% vs. 40% vs. 29%, p<0.05). Nine genes containing polymorphisms linked with AMPD1 C34T mutation were found in the HapMap database. AMPD1 C34T nonsense mutation is associated with reduced prevalence of diabetes and obesity in patients with CAD or HF, but A860T substitution seems to exert opposite metabolic effects and should always be accounted for in the studies of the AMPD1 genotype.

Ograniczanie wyników

Kliniczne znaczenie związku mikrobiota - leki

Mleko ludzkie - tkanka obronna i immunomodulujaca

Czy pokarm matki wczesniaka jest mniej wartosciowy?

Congenital candidiasis as a subject of research in medicine and human ecology

An age-related decrease in factor V Leiden frequency among Polish subjects

Sequence variants of chemokine receptor genes and susceptibility to HIV-1 infection

CYP17 and CYP19 genetic variants are not associated with age at natural menopause in Polish women

The association of ADA 2 allen of the adenosine deaminase gene with the susceptibility to coronary artery disease

AMPD1 gene mutations are associated with obesity and diabetes in Polish patients with cardiovascular diseases