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Boric acid as a protector against paclitaxel genotoxicity

100%

Turkez H., Tatar A., Hacimuftuoglu A., Ozdemir E.

Acta Biochimica Polonica

2010

tom 57

nr 1

95-97

Paclitaxel (PAC) is an anticancer drug used for treatments of breast, ovarian and lung cancers. However, little data is; available in the literature on its potential genotoxicity on healthy human cells. On the other hand, boron deficiency and supplementation exert important biological effects in human and animal tissues. The biological effects of dietary boron are defined, but its interaction with PAC is not known for therapeutic uses. The aim of the present study was to determine whether boric acid (BA) confer a protection against PAC genotoxicity. After the application of PAC (10 or 20 μg/l) and BA (2.5 or 5 mg/l), the genotoxic effects were assessed by sister chromatid exchange (SCE) and micronucleus (MN) tests in human blood cultures. We also analyzed nuclear division index (NDI) in peripheral lymphocytes. Our results showed that PAC significantly (P < 0.05) increased the frequencies of SCEs and the formations of MNs in peripheral lymphocytes as compared to controls. PAC decreased the nuclear division index in lymphocyte cultures. Boric acid did not show cytotoxic or genotoxic effects at the concentrations tested. Furthermore, the PAC-induced increases in the genotoxicity and cytotoxicity indices were diminished by the addition of BA. The present study suggests for the first time that BA can prevent the genotoxicity of PAC on human lymphocytes.

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Comparison of element contents in haricot beans grown under organic and conventional farming regime for human nutrition and health

100%

Akbaba U., Sahin Y., Turkez H.

Acta Scientiarum Polonorum. Hortorum Cultus

2012

tom 11

nr 2

Today, sustainable agriculture and food content is a very important issue in the world. Organic farming practices are very important in this respect.This study was made to observe the impact of organic agricultural regime on the products in case of haricot beans (Phaseolus vulgaris L.). A comparative study on elemental composition of various haricot beans (Phaseolus vulgaris L.) samples was conducted by using a sensitive method, wavelength dispersive X-ray fluorescence (WDXRF). 26 elements such as Al, Ca, Cu, Fe, As, Hg, Pb, Cd, Bi, Mn, Ni, P, S, Sr, Zn, Zr, La, Ti, Sn, Cl, K, Mg, Na, Ba, Rb and Si were determined in haricot beans samples (n=10) grown under organic and conventional farming regimes. The obtained results from each group were analyzed statistically by using SPSS statistic program. It was observed that the concentration and peak intensity values of Ca, Fe, Mn, P, Zn, Cl, K, Na, Mg and Si elements were higher in the haricot beans samples grown under organic farming regime. Likewise, Al and Sr levels were found in higher levels in the samples grown under conventional farming regime. Our findings clearly revealed that organic haricot beans are likely to have higher nutritional mineral content. And the haricot beans samples grown under conventional farming regime could contain harmful metals like Al and Sr that might damage the various systems and/or organs of humans and animals.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Acta Scientiarum Polonorum. Hortorum Cultus

2 Turkez H.

1 Akbaba U.

1 Hacimuftuoglu A.

1 Ozdemir E.

1 Sahin Y.

1 Tatar A.

1 2012

1 2010

Wyniki wyszukiwania

Boric acid as a protector against paclitaxel genotoxicity

Comparison of element contents in haricot beans grown under organic and conventional farming regime for human nutrition and health