Various orogenic deformation, land subsidence, the creation of flood plains, the initiation of slide processes, mining shocks, the problem of managing mining debris and storing a considerable fraction of mining debris on land surface in the form of heaps all these reflect the irreversible environmental degradation caused by mining. The mining industry devotes much attention to controlling the damage from coal mining and it is legally obliged to counteract those adverse effects. Great financial means are allocated to it, in recent years amounting to 2.5 per cent of exploitation costs. However, environmental degradation has not been brought under control and is extraordinary harmful.
Fourteen patients with peripheral vascular disease received 200 µg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in all 14 patients. An elongation of pain free and maximum walking distance, shortening of pain duration and increase in arterial blood flow in both calves were observed. At the same time an activation of the fibrinolytic system, rise in the platelet aggregate ratio and increase in cAMP levels were noticed. It is suggested that misoprostol in human being caused rather activation of IP2 receptor.