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1

Stowarzyszenie wychowanków SGGW. Z bieżącej działalności Zarządu

100%
Czyz J.
Agricola. Pismo SGGW
|
2003
|
nr 55
2

The stage-specific function of gap junctions during tumourigenesis

100%
Czyz J.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 1
92-102
Tumour development is a process resulting from the disturbance of various cellular functions including cell proliferation, adhesion and motility. While the role of these cell parameters in tumour promotion and progression has been widely recognized, the mechanisms that influence gap junctional coupling during tumorigenesis remain elusive. Neoplastic cells usually display decreased levels of connexin expression and/or gap junctional coupling. Thus, impaired intercellular communication via gap junctions may facilitate the release of a potentially neoplastic cell from the controlling regime of the surrounding tissue, leading to tumour promotion. However, recent data indicates that metastatic tumour cell lines are often characterized by relatively high levels of connexin expression and gap junctional coupling. This review outlines current knowledge on the role of connexins in tumorigenesis and the possible mechanisms of the interference of gap junctional coupling with the processes of tumour invasion and metastasis.
3

Zjawisko kontaktowego naprowadzania komorek

100%
Czyz J.
Postępy Biologii Komórki. Suplement
|
1993
|
tom 2
125-133
4

Wplyw ksztaltu komorek na wzrost, roznicowanie i przezywalnosc komorek

100%
Czyz J.
Postępy Biologii Komórki. Suplement
|
1995
|
nr 05
41-58
5

Pożegnanie przyjaciół z IV grupy

75%
Czyz J.
Agricola. Pismo SGGW
|
2003
|
nr 56
6

Wplyw czynnikow mechanicznych na aktywnosc proliferacyjna i ekspresje genow w komorkach zwierzecych.

63%
Jurkiewicz A., Czyz J.
Postępy Biologii Komórki. Suplement
|
1997
|
tom 08
101-118
7

Efficacy of the Frame and Hu mathematical model for the quantitative analysis of agents influencing growth of chick embryo fibroblasts

63%
Korohoda W., Czyz J.
Folia Histochemica et Cytobiologica
|
1994
|
tom 32
|
nr 2
8

Znane patogeny bakteryjne na mniej znanych gospodarzach

51%
Schollenberger M., Zamorski C., Czyz J., Mielecka M.
Zeszyty Problemowe Postępów Nauk Rolniczych
|
2008
|
tom 529
W warunkach szklarniowych określono podatność ośmiu gatunków i odmian jarzębów na zarazę ogniową. Do zakażeń użyto własnego izolatu bakterii wyosobnionego z jarzębu mącznego. Spośród badanych gatunków tylko jeden - Sorbus intermedia – nie uległ porażeniu, dwa uznano za mało podatne, a pozostałe za podatne. Na uwagę zasługuje różna podatność odmian w obrębie gatunku, co widoczne było na przykładzie jarzębu pospolitego i jego dwóch odmian. Na liściach magnolii obserwowano brązowo-czarną plamistość, która dominowała zarówno na roślinach w szkółkach, jak i w obrocie handlowym. Izolowaną z liści bakterię oznaczono na podstawie cech fenotypowych i testu patogeniczności. Sprawcą plamistości liści magnolii oraz towarzyszącej jej przedwczesnej defoliacji liści jest bakteria Pseudomonas syringae pv. syringae.
9

Przydatność analizatora hematologicznego CELL-DYNA 4000 w ocenie ilościowej produktów cytaferez

51%
Knopinska-Posluszny W., Skibowska A., Czyz J., Hellmann A.
Diagnostyka Laboratoryjna
|
2004
|
tom 40
|
nr 3
10

Komosa ryżowa - słabo znane pseudozboże o kosmicznych właściwościach

51%
Sulkowski M., Gawlik-Dziki U., Czyz J.
Kosmos
|
2011
|
tom 60
|
nr 3-4
11

Invasive Cx43high sub-line of human prostate DU145 cells displays increased nanomechanical deformability

51%
Piwowarczyk K., Sarna M., Ryszawy D., Czyz J.
Acta Biochimica Polonica
|
2017
|
tom 64
|
nr 3
12

Apigenin inhibits growth and motility but increases gap junctional coupling intensity in rat prostate carcinoma [MAT-LyLu] cell populations

51%
Czernik M., Sroka J., Madeja Z., Czyz J.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 3
327-338
Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid abundant in the common fruits, herbs and vegetables constituting the bulk of the human diet. This study was aimed at quantifying the effects of apigenin on the basic cellular traits determining cancer development, i.e. cell proliferation, gap junctional coupling, and motility, using the Dunning rat prostate MAT-LyLu cell model. We demonstrated that apigenin considerably inhibits MAT-LyLu cell proliferation and significantly enhances the intensity of connexin43-mediated gap junctional coupling. This effect correlates with an increased abundance of C×43-positive plaques at the cell-to-cell borders seen in apigenin-treated variants. Moreover, we observed an inhibitory effect of apigenin on the motility of MAT-LyLu cells. The basic parameters characterising MAT-LyLu cell motility, especially the rate of cell displacement, considerably decreased upon apigenin administration. This in vitro data indicates that apigenin may affect cancer development in general, and prostate carcinogenesis in particular, via its influence on cellular activities decisive for both cancer promotion and progression, including cell proliferation, gap junctional coupling and cell motility and invasiveness.
13

Anchorage-dependent chick embryo fibroblast synthesise DNA and proliferate when cultured in multilayered sheets suspended among glass fibres

51%
Czyz J., Dobrucki J., Korohoda W.
Folia Biologica
|
2001
|
tom 49
|
nr 1-2
14

Ascorbic acid inhibits the migration of Walker 256 carcinosarcoma cells

45%
Wybieralska E., Koza M., Sroka J., Czyz J., Madeja Z.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 1
103-111
The results of several experimental studies have shown that ascorbic acid inhibits tumor growth and metastasis. Ascorbic acid is an antioxidant that acts as a scavenger for a wide range of reactive oxygen species (ROS). Both tumour metastasis and cell migration have been correlated with the intracellular ROS level, so it was postulated that the inhibitory effect of ascorbic acid derivatives on cell motility may be caused by scavenging of ROS. Time-lapse analyses of Walker 256 carcinosarcoma cell migration showed that both the speed of movement and the cell displacement were inhibited by ascorbic acid applied in concentrations ranging from 10 to 250 μM. This effect correlated with a reduction in the intracellular ROS level in WC 256 cells, suggesting that ROS scavenging may be a mechanism responsible for the inhibition of WC 256 cell migration. However, another potent antioxidant, N-acetyl-L-cysteine, also efficiently decreased the intracellular ROS level in WC 256 cells, but did not affect the migration of the investigated cells. These results demonstrate that intact, unmodified ascorbic acid applied in physiologically relevant and nontoxicconcentrations exerts an inhibitory effect on the migration of WC 256 carcinosarcoma cells, and that this may be one of the factors responsible for the anti-metastatic activity of vitamin C. However, our data does not support the hypothesis that the scavenging of intracellular ROS is the main mechanism in the inhibition of cancer cell migration by ascorbic acid.
15

Spreading-independent growth of normal fibroblasts in three-dimensional cultures

45%
Czyz J., Rajwa B., Bzowska M., Dobrucki J., Korohoda W.
Folia Biologica
|
2004
|
tom 52
|
nr 1-2
16

The effect of tributyltin on human eosinophylic leukemia EoL-1 cells

39%
Sroka J., Wlosiak P., Wilk A., Antonik J., Czyz J., Madeja Z.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 1
67-73
Organotin compounds are chemicals that are widely used in industry and agriculture as plastic stabilizers, catalysts and biocides. Many of them, including tributyltin (TBT), have been detected in human food and, as a consequence, detectable levels have been found in human blood. As organotin compounds were shown to possess immunotoxic activity, we focused our attention on the effect of TBT on the basic determinants of the function of eosinophils, i.e. cell adhesiveness and motility. We used human eosinophylic leukemia EoL-1 cells, a common in vitro cellular model of human eosinophils. Here, we demonstrate that TBT causes a dose-dependent decrease in the viability of EoL-1 cells. When administered at sub-lethal concentrations, TBT significantly decreases the adhesion of EoL-1 cells to human fibroblasts (HSFs) and inhibits their migration on fibroblast surfaces. Since the basic function of eosinophils is to invade inflamed tissues, our results indicate that TBT, and possibly other organotin compounds, may affect major cellular properties involved in the determination of in vivo eosinophil function.
17

Curcumin augments the cytostatic and anti-invasive effects of mitoxantrone on carcinosarcoma cells in vitro

39%
Luty M., Kwiecien E., Firley M., Labedz-Maslowska A., Paw M., Madeja Z., Czyz J.
Acta Biochimica Polonica
|
2016
|
tom 63
|
nr 3
18

Multidirectional effects of triterpene saponins on cancer cells-mini-review of in vitro studies

39%
Koczurkiewicz P., Czyz J., Podolak I., Wojcik K., Galanty A., Janeczko Z., Michalik M.
Acta Biochimica Polonica
|
2015
|
tom 62
|
nr 3
19

Lclet 4 enhances pro-apoptotic and anti-invasive effects of mitoxantrone on human prostate cancer cells - in vitro study

39%
Koczurkiewicz P., Podolak I., Wojcik K. A., Galanty A., Madeja Z., Michalik M., Czyz J.
Acta Biochimica Polonica
|
2013
|
tom 60
|
nr 3
Triterpene saponosides are widely distributed plant secondary metabolites characterized by relatively low systemic cytotoxicity and a range of biological activities. These include anti-inflammatory, antimicrobial, vasoprotective and antitumor properties. In particular, the ability of saponins to enhance the cytotoxicity of chemotherapeutic drugs opened perspectives for their application in combined cancer chemotherapy. Here, we used human prostate cancer DU-145 cells as an in vitro model to elucidate the synergy of the interactions between biological activities of an oleanane type 13β,28-epoxy triterpene saponoside (Lclet 4) and mitoxantrone, which is a cytostatic drug commonly used in prostate cancer therapy. No cytotoxic or pro-apoptotic effect of Lclet 4 and mitoxantrone administered at the concentrations between 0.05 and 0.1 µg/ml could be seen. In contrast, cocktails of these agents exerted synergistic pro-apoptotic effects, accompanied by the activation of the caspase 3/7 system. This effect was paralleled by attenuating effects of Lclet 4/mitoxantrone cocktails on the invasive potential, metalloproteinase expression and motility of DU-145 cells. Multifaceted and additive effects of Lclet 4 and mitoxantrone on basic cellular traits crucial for prostate cancer progression indicate that the combined application of both agents at systemically neutral concentrations may provide the basis for new promising strategies of prostate cancer chemotherapy.
20

Connexin-dependent intercellular stress signaling in tissue homeostasis and tumor development

33%
Czyz J., Piwowarczyk K., Paw M., Luty M., Wrobel T., Catapano J., Madeja Z., Ryszawy D.
Acta Biochimica Polonica
|
2017
|
tom 64
|
nr 3
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