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Interactions between pregabalin and phenobarbital in the mouse maximal electroshock-induced seizure model: an isobolographic analysis

100%

Luszczki J. J.

Journal of Pre-Clinical and Clinical Research

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2009

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tom 03

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nr 2

2

Acute adverse-eff ect profile of ethosuximide and stiripentol in the grip-strength test in mice

100%

Luszczki J. J.

Journal of Pre-Clinical and Clinical Research

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2009

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tom 03

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nr 1

3

Role of vitamin A in health and illness

63%

Marzeda P., Luszczki J. J.

Journal of Pre-Clinical and Clinical Research

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2019

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tom 13

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nr 3

4

Interaction of three-drug combination of lacosamide, carbamazepine and phenobarbital in the mouse maximal electroshock-induced seizure model – an isobolographic analysis

63%

Kondrat-Wrobel M. W., Luszczki J. J.

Health Problems of Civilization

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2016

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tom 10

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nr 1

Background. Epilepsy is one of the serious neurological diseases characterized by seizures that affect about 1% of people worldwide (65 million), and therefore, epilepsy can be considered as a disease of civilization. Although seizures are controllable with antiepileptic drugs (AEDs) in about 70% of cases, it remains still about 30% of epilepsy patients inadequately medicated with these AEDs, who need a full control of their seizure attacks. One of the treatment options in these patients is application of two or three AEDs in combination. The aim of this study was to characterize the anticonvulsant effects of a combination of three AEDs (i.e., carbamazepine [CBZ], lacosamide [LCM] and phenobarbital [PB]) at the fixed-ratio of 1:1:1 in the mouse maximal electroshock (MES)-induced seizure model. Materials and methods. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via auricular electrodes. Type I isobolographic analysis was used to analyze the three-drug combination. Results. Type I isobolographic analysis revealed that the combination of CBZ, LCM and PB (at the fixed-ratio of 1:1:1) exerted additive interaction with a slight tendency towards antagonism in the mouse MES-induced seizure model. Conclusions. A special caution is advised to patients taking LCM in combination with CBZ and PB because this three-drug combination offered additive interaction with a slight tendency towards antagonism in the mouse MES model.

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Effect of topiramate and its combination with SIB-1893 on body temperature in rats

51%

Luszczki J. J., Ossowska G., Czuczwar S. J.

Journal of Pre-Clinical and Clinical Research

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2009

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tom 03

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nr 2

6

Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice

51%

Luszczki J. J., Marzeda E., Kondrat-Wrobel M. W., Florek-Luszczki M.

Journal of Pre-Clinical and Clinical Research

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2014

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tom 08

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nr 1

7

Importance of cannabinoids in the functioning of the central nervous system

51%

Wroblewska-Luczka P., Florek-Luszczki M., Luszczki J. J.

Health Problems of Civilization

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2018

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tom 12

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nr 3

At present, there is a great emphasis of public opinion on the legalisation of medical marijuana, i.e. the top parts of the cannabis plants rich in tetrahydrocannabinol (THC). Nevertheless, in the cannabis plants, there are many various cannabinoids, including cannabidiol (CBD). Scientific reports to-date indicate the possibility for using pharmacologically active cannabinoids in the treatment of such diseases/symptoms as: anorexia, vomiting, neuropathic pain, inflammatory diseases, multiple sclerosis, degenerative diseases of the central nervous system (Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Tourette’s syndrome), epilepsy, schizophrenia, and obesity. The article presents up-to-date information on the results of experimental studies concerning the effectiveness of cannabinoids, with particular consideration of diseases related with the central nervous system, including epilepsy, neuropathic pain, mental disorders, as well as obesity and anorexia.

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Interaction of tiagabine with clonazepam in the mouse pentylenetetrazole-induced seizure model: a type I isobolographic analysis for parallel log-probit dose-response relationship lines

45%

Luszczki J. J., Krzyzanowski M., Sielski M., Wojda E., Swiader M. J.

Journal of Pre-Clinical and Clinical Research

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2008

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tom 02

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nr 2

9

Social functioning of elderly people living in rural areas

45%

Dziechciaz M., Chmielewski J., Florek-Luszczki M., Czarny-Dzialak M. A., Luszczki J. J.

Health Problems of Civilization

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2018

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tom 12

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nr 3

Background. The aim of this work was to assess social functioning of elderly people living in rural areas. Material and methods. The authors used own interview questionnaire to collect the data. The study was conducted in 504 citizens, older than 65 years, from eight villages. Results. Women were more frequently widowed than men, had low educational level and lived alone. As most responses showed (51.98%), the received benefits did not cover the respondents’ current needs and 5.95% of them claimed that they were insufficient. The remaining respondents, i.e. 42.06%, stated that the available resources fulfilled their needs. The respondents would also point to family’s aid (n=411; 81.55%) or spouse’s aid (n=147; 29.56%). Only 37 people benefited from social care (n=504; 7.34%), of which 24 (64.86%) claimed that the help provided by social care was insufficient. Conclusions. Old women in rural areas tend to live alone more frequently, are widowed and have lower level of education than men. The received financial benefits do not fully cover current needs of older residents of rural areas regardless of sex. Among people of over 65 years living in rural areas, the majority (81.55%) would point to family support and only 2.18% indicated social care as a source of income.

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Occupational exposure to pesticides - a challenge for environmental health specialists and occupational medicine practitioners

45%

Czarny-Dzialak M., Chmielewski J., Gietka M., Gworek B., Luszczki J. J.

Journal of Elementology

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2022

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tom 27

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nr 3

11

Clinical considerations on the relationship between epilepsy and cardiovascular diseases

45%

Trojnar M. P., Kimber-Trojnar Z., Trojnar M. K., Luszczki J. J., Czuczwar S. J.

Journal of Pre-Clinical and Clinical Research

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2007

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tom 01

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nr 1

12

Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis

45%

Luszczki J. J., Wlaz A., Kondrat-Wrobel M. W., Pyrka D., Florek-Luszczki M.

Journal of Pre-Clinical and Clinical Research

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2014

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tom 08

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nr 2

The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.

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No effect of 7-nitroindazole on the anticonvulsant action of vigabatrin and oxcarbazepine in pentylenetetrazole-induced seizures in mice

39%

Luszczki J. J., Szadkowski M., Zadrozniak A., Wojda E., Dudra-Jastrzebska M., Andres-Mach M.

Journal of Pre-Clinical and Clinical Research

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2008

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tom 02

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nr 2

14

Importance of water, its quality and proper management as a challenge in environmental education

39%

Zeber-Dzikowska I., Bak-Badowska J., Gietka M., Gworek B., Wroblewska I., Luszczki J. J.

Journal of Elementology

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2022

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tom 27

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nr 1

15

Diltiazem enhances the protective activity of oxcarbazepine against maximal electroshock-induced seizures in mice

39%

Zadrozniak A., Trojnar M. K., Trojnar M. P., Kimber-Trojnar Z., Dudra-Jastrzebska M., Andres-Mach M. M., Luszczki J. J.

Journal of Pre-Clinical and Clinical Research

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2008

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tom 02

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nr 2

16

Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

39%

Luszczki J. J., Wlodarczyk M., Glensk M., Marzeda E., Durmowicz D., Florek-Luszczki M.

Journal of Pre-Clinical and Clinical Research

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2013

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tom 07

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nr 1

17

Isobolographic characterization of interaction of levetiracetam with clobazam in the mouse 6 Hz psychomotor seizure model

39%

Luszczki J. J., Walz A., Marzeda E., Podgorska D., Durmowicz D., Florek-Luszczki M.

Journal of Pre-Clinical and Clinical Research

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2012

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tom 06

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nr 1

18

Assessment of rural area residents' awareness of municipal waste incineration

39%

Chmielewski J., Gietka M., Wojtowicz B., Luszczki J. J., Gworek B., Zeber-Dzikowska I.

Journal of Elementology

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2022

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tom 27

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nr 3

19

No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice

39%

Luszczki J. J., Jaskolska A., Dworzanski W., Kominek M., Mazurkiewicz L. P., Ossowska G.

Journal of Pre-Clinical and Clinical Research

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2010

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tom 04

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nr 1

20

No effect of water extract of Scutellariae radix on the anticonvulsant action of valproate, tiagabine and topiramate in two animal models of epilepsy

39%

Andres-Mach M., Dudra-Jastrzebska M., Heratym-Maj A., Czerwonka A., Raszewski G., Luszczki J. J.

Journal of Pre-Clinical and Clinical Research

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2009

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tom 03

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nr 2

Ograniczanie wyników

Interactions between pregabalin and phenobarbital in the mouse maximal electroshock-induced seizure model: an isobolographic analysis

Acute adverse-eff ect profile of ethosuximide and stiripentol in the grip-strength test in mice

Role of vitamin A in health and illness

Interaction of three-drug combination of lacosamide, carbamazepine and phenobarbital in the mouse maximal electroshock-induced seizure model – an isobolographic analysis

Effect of topiramate and its combination with SIB-1893 on body temperature in rats

Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice

Importance of cannabinoids in the functioning of the central nervous system

Interaction of tiagabine with clonazepam in the mouse pentylenetetrazole-induced seizure model: a type I isobolographic analysis for parallel log-probit dose-response relationship lines

Social functioning of elderly people living in rural areas

Occupational exposure to pesticides - a challenge for environmental health specialists and occupational medicine practitioners

Clinical considerations on the relationship between epilepsy and cardiovascular diseases

Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis

No effect of 7-nitroindazole on the anticonvulsant action of vigabatrin and oxcarbazepine in pentylenetetrazole-induced seizures in mice

Importance of water, its quality and proper management as a challenge in environmental education

Diltiazem enhances the protective activity of oxcarbazepine against maximal electroshock-induced seizures in mice

Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

Isobolographic characterization of interaction of levetiracetam with clobazam in the mouse 6 Hz psychomotor seizure model

Assessment of rural area residents' awareness of municipal waste incineration

No effect of agmatine on the protective activity of clobazam and pregabalin against maximal electroshock-induced seizures in mice

No effect of water extract of Scutellariae radix on the anticonvulsant action of valproate, tiagabine and topiramate in two animal models of epilepsy