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W pracy sprawdzono wpływ jednorazowego podania myszom tetrabromobisfenolu-A na stężenie GSH i MDA w wątrobie oraz aktywność AlAT i ɣ-GT w surowicy. Zbadano także zanik [ 14C] tetrabromobisfenolu-A i jego kowalencyjnie związanych adduktów w wątrobie myszy. Zaobserwowano statystycznie znamienne obniżenie stężenia GSH i wzrost MDA oraz wzrost aktywności ɣ-GT.
In this study the attempt to assess nephrotoxicity of TBBF-A after repeated exposure was made, on the basis of selected biochemical parameters.
The aim of the present study was to investigate the influence of tetrabromobenzene after 28 days administration on biochemical indicators. The increase in relative liver mass as well as changes in the levels of cytochromes P-450 were observed. Porphyrins excreted in urine does not indicate strong porphyrogenic effect. No statistically significant changes were detected in other indicators of toxicity (MDA, GSH, ALT, rGT).
The aim of this study was to complete research on the porphyrogenic effect of hexabrombenzene (HBB) and tetrabromobisphenol-A (TBBP-A). Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography. Repeated HBB administration caused a 3-8 times increase of total concentration of high carboxylated porphyrins (octa- and heptacarboxyporphyrins). The concentrations of these porphyrins were significantly lower in the liver of rats exposed to tbbp-a. However, in the kidneys significant alterations in porphyrins concentrations concerned only HBB.
Hairy roots of Dracocephalum moldavica L. were induced using Agrobacterium rhizogenes strain A4. Transformed roots were obtained from shoot explants with low transformation frequency of up to 3 %. The effects of different liquid media: Murashige and Skoog (MS), Gamborg et al. (B5) and Woody Plant (WP) with full- and half-strength (1/2MS, 1/2B5, 1/2WP), on biomass accumulation and rosmarinic acid (RA) content were investigated. The hairy roots were cultured in photoperiod (16 h light/8 h dark) and darkness. Biomass of D. moldavica hairy roots was the highest (7.23 g flask-1 of fresh weight and 0.89 g flask-1 of dry weight) in the cultures grown in WP medium under periodic light. Ultra performance liquid chromatography analysis revealed the highest RA content (78 mg g-1 dry wt) in roots cultured in 1/2B5 medium under photoperiod conditions. It was about tenfold higher compared to roots of field-grown mother plants. Antioxidant activities and total phenolic contents of methanolic extracts of D. moldavica hairy roots cultured in 1/2B5 and WP media under photoperiod and darkness and roots of field grown plants were compared. All extracts were investigated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging and phosphomolybdenum reduction assays. Total phenolic contents were estimated by the Folin– Ciocalteu method. The methanolic extract of D. moldavica hairy roots grown in 1/2B5 medium under photoperiod possessed the strongest effects on reducing Mo and DPPH radical scavenging. The activities were significantly higher (p B 0.05) than those of methanolic extract of roots of intact plants grown in the field. The most active methanolic extract of hairy roots was characterized by the highest level of rosmarinic acid and total content of phenolic compounds.
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