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Thrombolytic and antiplatelet action of Xanthinol nicotinate [Sadamin]: possible mechanisms

100%

Bieron K., Swies J., Kostka-Trabka E., Gryglewski R. J.

Journal of Physiology and Pharmacology

1998

tom 49

nr 2

Misoprostol as agonist of IP2 receptor

100%

Goszcz A., Bieron K., Grodzinska I.

Journal of Physiology and Pharmacology

2002

tom 53

nr 4,1

Fourteen patients with peripheral vascular disease received 200 µg of misoprostol 3 times a day during one month. The therapy with misoprostol caused clinical and biochemical improvement in all 14 patients. An elongation of pain free and maximum walking distance, shortening of pain duration and increase in arterial blood flow in both calves were observed. At the same time an activation of the fibrinolytic system, rise in the platelet aggregate ratio and increase in cAMP levels were noticed. It is suggested that misoprostol in human being caused rather activation of IP2 receptor.

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

2 Bieron K.

1 Goszcz A.

1 Grodzinska I.

1 Gryglewski R. J.

1 Kostka-Trabka E.

1 Swies J.

1 2002

1 1998

Wyniki wyszukiwania

Thrombolytic and antiplatelet action of Xanthinol nicotinate [Sadamin]: possible mechanisms

Misoprostol as agonist of IP2 receptor