Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 4

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1
Content available remote

Effect of sex and localization dependent differences of Na,K-ATPase properties in brain of rats

100%
Kolocayova B., Vrbjar N.
Journal of Physiology and Pharmacology
|
2020
|
tom 71
|
nr 2
2
Content available remote

Sex-specific response of renal Na,K-ATPase to prenatal angiotensin 2 exposure and increased salt intake in offspring

71%
Jagmasevic-Mezesova L., Svitok P., Kalocayova B., Zeman M., Vrbjar N.
Journal of Physiology and Pharmacology
|
2018
|
tom 69
|
nr 1
3
Content available remote

Localization dependent sensitivity of cerebral Na,K-ATPase to irradiation induced oxidative imbalance in rats

61%
Kolocayova B., Kovacicova I., Radosinska J., Tothova L., Fulop M., Slezak J., Vrbjar N.
Journal of Physiology and Pharmacology
|
2019
|
tom 70
|
nr 4
4
Content available remote

Effect of quercetin on kinetic properties of renal Na,K-ATPase in normotensive and hypertensive rats

61%
Mezesova L., Bartekova M., Javorkova V., Vlkovicova J., Breier A., Vrbjar N.
Journal of Physiology and Pharmacology
|
2010
|
tom 61
|
nr 5
The effect of quercetin, a plant-derived bioflavonoid with documented positive effect on the cardiovascular system, was examined after 4-week supplementation in the dose of 20 mg kg-1·day-1 to young male normotensive control (C) and to spontaneously hypertensive rats (SHR) over the period of their 5th-8th week of age. The study was focused on the influence of quercetin on properties of the renal Na,K-ATPase, a key system in maintaining the homeostasis of sodium in the organism. Spontaneous hypertension by itself enhanced the activity of Na,K-ATPase probably as a consequence of a higher number of active enzyme molecules, as suggested by the 15% increase of Vmax, along with improved affinity to ATP, as indicated by the 30% decrease in the value of Michaelis-Menten constant Km in untreated SHR vs. untreated normotensive rats. Quercetin induced a decrease of Na,K-ATPase activity in the presence of all ATP and Na+ concentrations investigated. Evaluation of kinetic parameters resulted in a constant Vmax value. The ATP-binding properties of the enzyme were not influenced by quercetin, as suggested by statistically insignificant changes in the value of Km both in controls and in SHR. On the other hand, the affinity to sodium decreased, as suggested by an increase in the KNa value by 22% and 31% in normotensive and hypertensive groups, respectively. This impairment in the affinity of the Na+-binding site of Na,K-ATPase molecules was probably responsible for the deteriorated enzyme function in the kidneys of quercetin treated animals.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.