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1

Rola kwasów tłuszczowych omega-3 i omega-6 w organizmie człowieka

100%
Materac E., Marczynski Z., Bodek K. H.
Bromatologia i Chemia Toksykologiczna
|
2013
|
tom 46
|
nr 2
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Selected excipients and surfactants in oral solid dosage form with extract of Phaseoli pericarpium (Phaseolus vulgaris L.)

100%
Marczynski Z., Kowalczykiewicz K., Bodek K. H.
Herba Polonica
|
2015
|
tom 61
|
nr 4
The common bean (Phaseolus vulgaris L.) is an annual plant grown in many countries all over the world including its different varieties in Poland. Herbal raw material are elongated pods – pericarp. Phaseoli pericarpium decreases the glucose blood level. Phaseoli pericarpium extracts manifest duretic properties, can be used in the treatment of edema, kidney diseases with decreased urinary excretion, nephrolithiasis. To investigate the usefullness of selected excipients as carriers of dry extract from Phaseolus vulgaris pericarp. Methods: The method of direct tableting was used. In the further stage, the obtained tablets were subjected to appropriate tests. The first stage of the study evaluates Prosolv SMCC 50, PROSOLV EASYtab, EMDEX, Carmellose calcium and PRUV. These were used to manufacture 4 batches of tablets. In the second stage, an oral solid dosage was manufactured on the basis of the formulation composition of batch 1 tablets (Phaseoli pericarpium extract, Prosolv SMCC 50, PRUV). Then, different surfactants (cholesterol oxyethylate nTE = 30, cholesterol oxyethylate nTE = 40, Rofam nTE = 50), were successively added to this formulation, to obtain 3 batches of tablets. All 7 batches were manufactured in the Erweka tableting machine. Then, they were subjected to morphological tests and physicochemical evaluation. The release of active substances to 3 selected acceptor fluids (water, artificial gastric juice, artificial intestinal juice) was measured in accordance with the requirements of the general and specific monographs in European Pharmacopoeia 7. Results: The manufactured tablets had a smooth uniform surface with no stains, spalls or mechanical damage and yellow color originating from the extract. The obtained tablets, with surfactants in their com- Herba Pol 2015; 61(4): 78-92 EXPERIMENTAL PAPER 79 Selected excipients and surfactants in oral solid dosage form with extract of Phaseoli pericarpium (Phaseolus vulgaris L.) Vol. 61 No. 4 2015 position, demonstrated pharmaceutical availability slightly higher than batch 1 tablets without surfactants. Conclusions: Excipients applied in appropriate proportions appear to be useful in the manufacturing of uncoated tablets containing extract of Phaseoli pericarpium.
3

Zastosowanie kwasów tłuszczowych omega-3 w profilaktyce i terapii chorób

100%
Materac E., Bodek K. H., Marczynski Z.
Bromatologia i Chemia Toksykologiczna
|
2013
|
tom 46
|
nr 3
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Extract from Zingiber officinale Rosc. in oral solid from of a drug

100%
Marczynski Z., Zgoda M. M., Bodek K. H.
Herba Polonica
|
2010
|
tom 56
|
nr 1
35-47
It has been decided to investigate the usefulness of selected acrylic acid polymers (Carbopols), chitosan and microcrystalline cellulose as dominating carriers of dry extract from ginger rhizome (Zingiber officinale Rosc.) in an oral solid form of a drug. The aim of the study was to obtain tablets in the course of direct tableting of controlled release of biologically active substances. Seven batches of tablets were manufactured in reciprocating instrumented tableting machine and the effect of the kind of applied adjuvant substances on the rate of biologically active substances release from the produced tablets was evaluated. Physicochemical parameters were determined in order to test the produced tablets. The tablets containing acrylic acid polymers (Carbopol 71 GNF, Carbopol 974 PNF) demonstrated the highest hardness. The tests of pharmaceutical availability of biologically active substances from tablets to the acceptor fluid 0,1 mol/l HCl and comparatively to hydrating intervention hypotonic fluid and to pediatric compensating fluid were performed. The investigations fulfilled general and detailed requirements of Polish Pharmacopoeia VII. Tablets containing Carbopol 71 GNF as dominating carrier of the extract, Vivapur 112 and Prosolv HD 90 demonstrated high pharmaceutical availability. Introduction of Prosolv SMCC 50 together with dominating carriers of the extract had a beneficial effect on pharmaceutical availability of biologically active substances from the tested tablets. It results from the carried out investigations that the kind of the applied adjuvant substances and differentiated osmolarity of model acceptor fluids significantly decide on pharmaceutical availability of hydrophilic therapeutic agents contained in dry extract from ginger rhizome. The adjuvant substances applied in adequate proportions appeared to be useful for manufacturing tablets containing dry extract from ginger rhizome.
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