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1
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The role of perivascular adipose tissue and endogenous hydrogen sulfide in vasoactive responses of isolated mesenteric arteries in normotensive and spontaneously hypertensive rats

100%
Cacanyiova S., Majzunova M., Golas S., Berenyiova A.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 2
2
Content available remote

Hypotrophic effect of long-term neuronal NO-synthase inhibition on heart and conduit arteries of the Wistar rats

100%
Kristek F., Cacanyiova S., Gerova M.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 2
21-27
We demonstrate the effect of long-term nNOS inhibition with 7-nitroindazole (7NI) on the heart and conduit arteries. Ten weeks old Wistar rats were used: two groups of controls and rats receiving 7-NI (10 mg/kg b.w./day) for 6 weeks in drinking water. Blood pressure (BP) was measured by the plethysmographic method. In first group mesenteric, carotid and coronary arteries were excised after perfusion fixation (120 mmHg) for morphological study, in second group mesenteric artery was taken for functional investigation. 7NI did not affect BP, heart/body weight was decreased. In all arteries inner diameter (ID) did not changed, wall thickness (WT) (intima+media), cross sectional area (CSA) (intima+media), and WT/ID decreased. In carotid artery volume density (VD) (percentual proportion) of intima and media did not change; VD and CSAs of endothelial and smooth muscle cells decreased, CSAs of extracellular matrix in intima and media did not change. No difference was found in relaxation of mesenteric artery to acetylcholine (10-9-10-5 mol/L). Contraction induced by transmural nerve stimulation (8Hz) augmented and contraction to exogennous noradrenaline (10-9-10-5 mol/L) attenuated. Long-term 7NI administration evoked pressure independent cardiac hypotrophy and due to decrease of endothelial and smooth muscle cell mass arterial wall hypotrophy associated with decreased contractile efficiency.
3
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Blood pressure-independent hypotrophy of the heart, kidneys and conduit arteries after 7-nitroindazole administration to Wistar rats from the prenatal period to adulthood

100%
Kristek F., Malekova M., Ondrias K., Cacanyiova S.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 1
4
Content available remote

Effect of chronic neuronal nitric oxide-synthase inhibition on arterial function and structure in spontaneously hypertensive rats

100%
Cacanyiova S., Kristek F., Malekova M., Ondrias K.
Journal of Physiology and Pharmacology
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2012
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tom 63
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nr 1
5
Content available remote

The role of oxidative stress in acetylcholine-induced relaxation of endothelium-denuded arteries

100%
Cacanyiova S., Dovinova I., Kristek F.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 2
6
Content available remote

Changes in the vasoactive effects of nitric oxide, hydrogen sulfide and the structure of the rat thoracic aorta: the role of age and essential hypertension

88%
Berenyiova A., Drobna M., Cebova M., Kristek F., Cacanyiova S.
Journal of Physiology and Pharmacology
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2018
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tom 69
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nr 4
7
Content available remote

The adaptive role of nitric oxide and hydrogen sulphide in vasoactive responses of thoracic aorta is triggered already in young spontaneously hypertensive rats

76%
Cacanyiova S., Berenyiova A., Kristek F., Drobna M., Ondrias K., Grman M.
Journal of Physiology and Pharmacology
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2016
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tom 67
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nr 4
8
Content available remote

Nitroso-sulfide coupled signaling triggers specific vasoactive effects in the intrarenal arteries of patients with arterial hypertension

64%
Cacanyiova S., Berenyiova A., Balis P., Kristek F., Grman M., Ondrias K., Breza J., Breza Jr J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 4
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