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Lekowrazliwosc oraz czestosc wystepowania wybranych grup bakterii izolowanych w 2001 roku od pacjentow Swietokrzyskiego Centrum Onkologii

100%

Durnas B., Gozdz S., Piestrak E., Zolcinska D., Dzierzanowska D.

Medycyna Doświadczalna i Mikrobiologia

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2003

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tom 55

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nr 3

285-295

Oceniono częstość występowania oraz lekowrażliwość drobnoustrojów najczęściej izolowanych z próbek materiału klinicznego pobranych od pacjentów Świętokrzyskiego Centrum Onkologii w Kielcach w 2001 roku, z uwzględnieniem podziału na rodzaje zakażeń. Najczęściej izolowano Escherichia coli i Staphylococcus aureus. Escherichia coli wytwarzające ESBL stanowiły 2,7% ogółu szczepów tego gatunku izolowanych z próbek materiału klinicznego pobranych od pacjentów hospitalizowanych, natomiast gronkowce złociste oporne na metycylinę 27,9% ogółu szczepów Staphylococcus aureus.

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Trends of premature mortality in Swietokrzyskie Province (Poland), years 2002-2010

100%

Gozdz S., Krzyzak M., Maslach D., Wrobel M., Bielska-Lasota M.

Roczniki Państwowego Zakładu Higieny

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2013

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tom 64

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nr 3

Background. Premature mortality in younger age groups influences the society as far as social and economic aspects are concerned. Therefore, it is important to come up with a tool which will allow to assess them, and will enable to implement only these health care measures that bring tangible benefits. That is the reason for introducing PYLL rate (PYLL - potential years of life lost), which is an addition to the analysis of premature mortality as it includes the number of deaths due to a particular cause and the age at death. Objective. The purpose of this study was to analyse the level and trends of PYLL rate according to death causes in years 2002 -2010in Świętokrzyskie Province. Material and methods. The material for the analysis was the information from the Central Statistical Office on the number of deaths due to all causes registered among the inhabitants of Świętokrzyskie Province in years 2002-2010. Causes of death were coded according to the 10th revision of the International Classification of Diseases. The analysis of premature mortality was carried out with the use of PYLL rate. PYLL rate was calculated according to the method proposed by Romeder, according to which the premature mortality was defined as death before the age of 70. The analysis of time trends of PYLL rate and the APC (annual percent change) of the PYLL rate were calculated usingjointpoint model as well as the Jointpoint Regression Program (Version 4.0.1 - January 2013). Results. In men, in years 2002 - 2007 PYLL rate increased by 1.5% per year (p<0.05). From year 2007 the trend went downward and PYLL rate decreased on average by 3.1% per year till year 2010. External causes of death, cardiovascular diseases and cancers in years 2002 - 2010 were the reason for almost 74.0% PYLL in men. In year 2010 PYLL rate due to all death causes amounted to 89 13.8/105 and was three times higher than in women (29 75.5/105). In women, however, during the analysed period PYLL rate did not change significantly, and was dominated by cancers, cardiovascular diseases and external death causes. Similarly to men, those three groups of death causes were responsible for an average 76.0% PYLL. Conclusions. The analysis of the causes of premature mortality in Świętokrzyskie Province shows that in the majority of cases it is due to preventable deaths, which calls for the necessity of more intensive measures in primary and secondary prevention as well as the improvement in treatment standards, mainly of cardiovascular diseases, cancers, injuries and accidents.

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The role of cathelicidin LL-37 in cancer development

72%

Piktel E., Niemirowicz K., Wnorowska U., Watek M., Wollny T., Gluszek K., Gozdz S., Levental I., Bucki R.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 1

4

Changes in survival of colorectal cancer patients in Swietokrzyskie Province (Southern Poland) from the second half of the 1990s to the early 21st century - a population-based study

72%

Macek P., Biskup M., Ciepiela P., Terek-Derszniak M., Sosnowska-Pasiarska B., Krol H., Smok-Kalwat J., Gozdz S.

Annals of Agricultural and Environmental Medicine

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2020

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tom 27

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nr 2

5

Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis

59%

Wegierek-Ciuk A., Arabski M., Kedzierawski P., Florek A., Solowiej D., Gozdz S., Lisowska H., Kowalik A., Kowalska M., Wojcik A., Polanska J., Lankoff A.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 2

Introduction and objective. According to the cancer epidemiology databases, cancer is the second leading cause of death in developing countries. Moreover, the WHO predicts a continuing increase in the incidence of cancer, extending this trend well into the next several decades. Hence, it seems obvious that the prediction of cancer susceptibility and early diagnosis is an important goal for modern biomedical sciences. The aim of this study is to clarify the value of chromosomal damage, capacity for the repair of double-strand breaks (DSBs), polymorphisms in DNA repair genes, and apoptosis as prognostic markers for prostate and cervical cancer. Materials and methods. 30 prostate cancer patients and 30 cervical cancer patients were enrolled into the study. In addition, 30 healthy female donors and 30 healthy male donors served as controls. The following endpoints were investigated: frequency of micronuclei, gamma-H2AX fluorescence, XRCC1 194C>T, XRCC1 399G>A, XRCC3 IVS5–14 A>G, OGG1 326 Ser>Cys polymorphisms and apoptosis. Results. Among all tested factors, only the homozygous variant (Arg/Arg) in XRCC1 (399 Arg/Gln) was strongly associated with prostate cancer risk, and only a low apoptotic response was connected with cervical cancer risk. The presented study confirmed a positive association between the frequency of MN and increased prostate and cervical cancer risk. However, such a biomarker is not cancer specific. In addition, the information gained by analyzing the gamma-H2AX fluorescence, as well apoptosis, had no value for predicting the risk of prostate and cervical cancers. Conclusions. The final conclusion of the study is that cancer susceptibility is a complex phenotype not readily detectable in relatively small studies by functional assays or analysis of SNP in few, selected genes.

Ograniczanie wyników

Lekowrazliwosc oraz czestosc wystepowania wybranych grup bakterii izolowanych w 2001 roku od pacjentow Swietokrzyskiego Centrum Onkologii

Trends of premature mortality in Swietokrzyskie Province (Poland), years 2002-2010

The role of cathelicidin LL-37 in cancer development

Changes in survival of colorectal cancer patients in Swietokrzyskie Province (Southern Poland) from the second half of the 1990s to the early 21st century - a population-based study

Searching for in vitro biomarkers of susceptibility to prostate and cervical cancers by analysis of chromosomal instability, gamma-H2AX foci, polymorphisms in DNA repair genes and apoptosis