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Smad1 stabilization and delocalization in response to the blockade of BMP activity

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Li L., Wang J., Fung Ling Chau J., Liu H., Li B., Hao A., Li J.

Cellular and Molecular Biology Letters

2013

tom 18

nr 3

Signaling at the plasma membrane receptors is generally terminated by some form of feedback regulation, such as endocytosis and/or degradation of the receptors. BMP-Smad1 signaling can also be attenuated by BMP-induced expression of the inhibitory Smads, which are negative regulators of Smad1 transactivation activity and/or BMP antagonists. Here, we report on a novel Smad1 regulation mechanism that occurs in response to the blockade of BMP activity. Lowering the serum levels or antagonizing BMPs with noggin led to upregulation of Smad1 at the protein level in several cell lines, but not to upregulation of Smad5, Smad8 or Smad2/3. The Smad1 upregulation occurs at the level of protein stabilization. Upregulated Smad1 was relocalized to the perinuclear region. These alterations seem to affect the dynamics and amplitude of BMP2-induced Smad1 reactivation. Our findings indicate that depleting or antagonizing BMPs leads to Smad1 stabilization and relocalization, thus revealing an unexpected regulatory mechanism for BMP-Smad1 signaling.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Fung Ling Chau J.

1 Hao A.

1 Li B.

1 Li J.

1 Li L.

1 Liu H.

1 Wang J.

1 2013

Wyniki wyszukiwania

Smad1 stabilization and delocalization in response to the blockade of BMP activity