A field experiment was condueted in 2005–2007. Factors examined in the experiment included two potato cultivars (Balbina, Irga) and four weeding methods (control object, Plateen 41,5 WG, Racer 250 EC, Sencor 70 WG). On the chemically treated objects, as compared with mechanical weeding, the obtained increase of market yield of tubers was 22.9–126.9 dt/ha. The index of cost defrayal amounted to 1.69–5.60 and was the highest in the cultivar Irga in comparison with Balbina. Orientation indexes of profitability indicate that chemical protection of the potato was profitable.