Wyniki wyszukiwania

1

The renaissance of vitamin D

100%

Wierzbicka J., Piotrowska A., Zmijewski M. A.

Acta Biochimica Polonica

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2014

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tom 61

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nr 4

2

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

100%

Tukaj S., Trzonkowski P., Tukaj C.

Acta Biochimica Polonica

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2012

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tom 59

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nr 3

Inflammatory response has been recognized as a central feature in the development and progression of atherosclerosis, and VSMCs (Vascular Smooth Muscle Cells) - the main cellular component of media, play an important role in this process. Many reports indicate that the biologically active vitamin D metabolite - 1,25-dihydroxyvitamin D3 (1,25(OH)2D3 = calcitriol), besides its well established role in calcium homeostasis, plays an essential role in the regulation of the inflammation process. The aim of this study was to determine the regulatory effects of calcitriol, applied at two supra-physiological doses (10 nM and 100 nM), in VSMC culture. Secretion of the pro-inflammatory cytokines, IL-6 and TNF-α, was significantly attenuated in calcitriol-treated VSMC culture, but the level of anti-inflammatory TGF-β was generally unchanged. Since in advanced atherosclerosis lesions several cell types, including VSMCs, overproduce the HSP70 chaperone protein, we also checked the effects of calcitriol on its synthesis. The presence of 1,25(OH)2D3 did not affect HSP70 synthesis under physiological conditions but the synthesis of HSP70 in VSMCs exposed to heat shock was significantly inhibited by calcitriol (=100 nM). We observed that 1,25(OH)2D3 induced SOD 1 activity, stimulated the expression of IκB-α, and did not influence the level of NF-κB-p65 in VSMCs. The results of our study suggest that 1,25(OH)2D3 may serve as a natural anti-inflammatory agent and may therefore play a beneficial role in the physiology of VSMC in some contexts of atherosclerosis.

3

Subtypes of the Gc gene (vitamin D binding protein) in the Polish population

100%

Lesko D., Schlesinger D., Halasa J., Manczak M.

Archivum Immunologiae et Therapiae Experimentalis

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1988

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tom 36

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nr 6

4

Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves' disease

100%

Horst-Sikorska W., Ignaszak-Szczepaniak M., Marcinkowska M., Kaczmarek M., Stajgis M., Slomski R.

Acta Biochimica Polonica

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2008

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tom 55

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nr 2

371-380

Graves’ (GD) hyperthyroidism induces accelerated bone turnover that leads to decreased bone mineral density (BMD). The role of the VDR gene in predisposition to primary osteoporosis has been recognized. Recent studies show associations between the VDR gene polymorphisms and susceptibility to autoimmune diseases. Here we analyzed if VDR gene polymorphisms: BsmI, ApaI, TaqI, and Fok I may predispose women with Graves’ hyperthyroidism to BMD reduction or to disease development. The subjects were 75 premenopausal female Polish patients with GD and 163 healthy women. The genotyping was performed by the use of the restriction fragment length polymorphism analysis (RFLP). We studied the association of the VDR polymorphisms and their haplotypes with patients’ BMD and also SNPs and haplotypes association with Graves’ disease. We found a strong linkage disequilibrium for the BsmI, ApaI, and Taq I polymorphims that formed three most frequent haplotypes in Graves’ women: baT (47.9%), BAt (34.9%), and bAT (16.4%). We did not show statistically significant association of analyzed VDR polymorphisms or haplotypes with decreased bone mineral density in Graves’ patients. However, the presence of F allele had a weak tendency to be associated with Graves’ disease (with OR=1.93; 95% CI: 0.97–3.84; p=0.058). In conclusion: VDR gene polymorphisms do not predict the risk of decreased BMD in Polish women with Graves’. It may be speculated that the F allele carriers of the VDR Fok I polymorphism are predisposed to Graves’ disease development

5

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Dietary intake of vitamin D in obese children aged 1-3 years with simple obesity

100%

Strucinska M., Rowicka G., Dylag H., Riahi A., Bzikowska A.

Roczniki Państwowego Zakładu Higieny

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2015

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tom 66

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nr 4

Background. Obese children are predisposed to vitamin D deficiency. Most of the findings suggest that requirement for vitamin D is increased in obese children due to this vitamin sequestration in adipose tissue. Objective. The aim of the study was to evaluate dietary intake of vitamin D in children with simple obesity in relation to nutritional standards. Materials and Methods. The study included 73 children aged 1-3 years: 38 with simple obesity (group I) and 35 non-obese ones (group II - control). The inclusion criterion for the obese group was BMI z-score > +2.0, for the control group BMI z-score between -1.0 and +1.0.The intake of vitamin D was estimated using the Dieta 5.0 software on the basis of 3-days dietary record. Outcomes were related to nutritional standards. Differences in intake of energy and nutrients between both groups were assessed using the Mann-Whitney test (statistical significance was set at p = 0.05). Results. Vitamin D intake in both groups was below the nutritional standards (10 μg/400 IU). Median values / interquartile ranges of results were 2.0 / 1.3-5.9 μg and 4.0 / 1.1-7.6 μg daily, for obese and non-obese children, respectively. The risk of deficient vitamin D intake was observed in 94.7% of obese children and in 82.4% of control group. The main dietary source of vitamin D in both groups was growing-up milk/Junior formula. The median intake of energy, protein, fat and carbohydrates in the obese children were significantly higher than in the control group (p<0.05). Conclusions. In obese children aged 1-3 years adequate dietary intake of vitamin D was not achieved. Similarly, the intake of vitamin D by normal weight children was lower than recommended. Consequently, it is necessary to provide products rich in vitamin D in the diet of toddlers, particularly obese.

6

Effect of administration of two forms of vitamin D in a feed mixture on the strength traits of the femur bone of broiler chickens

84%

Michalczuk M., Szara T., Bereznowski A., Serwa U., Winkowski M.

Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego

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2010

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tom 06

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nr 2

7

Serum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients

84%

Golembiewska E., Safranow K., Kabat-Koperska J., Myslak M., Ciechanowski K.

Acta Biochimica Polonica

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2013

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tom 60

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nr 2

Aim: Active vitamin D (1,25-dihydroxyvitamin D3), PTH, fibroblast growth factor-23 (FGF-23) and Klotho protein are key regulators of phosphate metabolism. Hyperphosphatemia and increased FGF-23 level in patients with end-stage renal disease are associated with increased morbidity and mortality. The relationships among key regulators of phosphate metabolism are still being investigated. FGF-23, the humoral factor involved in phosphate metabolism, is strongly associated with serum phosphorus level. Klotho, a transmembrane protein expressed primarily in renal tubules, functions as an obligatory co-receptor for FGF-23. The soluble form of Klotho, produced by the shedding of the transmembrane protein, is detectable in body fluids. The purpose of the study was to assess if serum soluble alpha-Klotho level was related to phosphate metabolism parameters and residual renal function (RRF) in incident peritoneal dialysis (PD) patients. Methods: Thirty-five clinically stable patients 4 to 6 weeks after the onset of PD were included in the study. For each patient, clinical and laboratory data were reviewed. Serum phosphorus concentration, urinary and peritoneal phosphate clearance, serum FGF-23 and soluble Klotho protein concentrations were determined. Results: Serum soluble alpha-Klotho was strongly negatively correlated with 24-hour diuresis (Rs = -0.55, p = 0.004) and renal phosphate clearance (Rs = -0.40, p = 0.049), but not with RRF. Conclusions: Serum soluble Klotho protein concentration is inversely related to residual diuresis and renal phosphate clearance in incident PD patients.

8

Decreased serum adiponectin reflects low vitamin D, high interleukin 6, and poor physical performance in knee osteoarthritis

84%

Udomsinprasert W., Manoy P., Yuktanandana P., Tanavalee A., Anomasiri W., Honsawek S.

Archivum Immunologiae et Therapiae Experimentalis

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2020

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tom 68

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nr 3

9

Vitamin D and its relevance in the etiopathogenesis of oral cavity diseases

84%

Slebioda Z., Szponar E., Dorocka-Bobkowska B.

Archivum Immunologiae et Therapiae Experimentalis

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2016

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tom 64

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nr 5

10

Wyniki zastosowania metody zapobiegawczej do oznaczania biologicznej aktywnosci witaminy D, na podstawie pomiarów szerokości chrząstki przynasadowej

84%

Rakowska M., Kossakowska M.

Roczniki Państwowego Zakładu Higieny

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1962

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tom 13

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nr 3

11

Health outcomes of vitamin D. Part II. Role in prevention of diseases

84%

Wranicz J., Szostak-Wegierek D.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 4

Apart from the classic role of vitamin D, its hormonal active form, calcitriol is also characterized by pleiotropic effects on various organs and tissues. For the last several years, many researchers have shown an association between deficiency of vitamin D and the risk of type 2 diabetes mellitus (T2DM). Recent investigations suggested the need of vitamin D supplementation in T2DM prevention. It was shown that vitamin D deficiency decreases insulin secretion. It was also observed that proper vitamin D supplementation may improve the ability of the cells of the islets of Langerhans to synthesize many proteins de novo and to convert proinsulin to insulin. Apart from regulating bone metabolism and also calcium and phosphate homeostasis, 1,25(OH)2D3 exerts antiproliferative and pro-differentiating effects on a wide variety of cell types. It also induces apoptosis of cancer cells and slows their proliferation. In a number of major studies the relationship between low vitamin D levels and increased risk of various cancers was observed. It concerns colorectal, lung, prostate, breast and ovarian cancer. It was observed that in patients with low serum vitamin D concentrations such disorders as ischemic heart disease, heart attack, stroke, cardiac arrhythmia, and hypertension were more frequent and mortality was significantly higher. These results led the researchers to consider vitamin D deficiency as a potential risk factor for cardiovascular diseases. The possible mechanism in the pathogenesis of cardiovascular diseases that may be related to low levels of vitamin D, is its adverse effect on the renin-angiotensin-aldosterone system (RAAS). Calcitriol is also an important determinant of muscle cell proliferation and differentiation, as well as inhibition of apoptosis. Vitamin D is synthesized in the skin. However, there are only a few food products that are rich in vitamin D3, e.g.: fish oils, fish and fortified-products, such as dairy products and margarines. Individuals who are vulnerable to vitamin D deficiency should be supplemented.

12

Frequency of consumption of foods rich in calcium and vitamin D among school-age children

84%

Kostecka M.

Roczniki Państwowego Zakładu Higieny

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2016

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tom 67

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nr 1

Background. Calcium is one of the most important minerals for the human body which is essential for healthy bones and teeth. Vitamin D has hormone-like properties in the human body. It is supplied with the diet, but it is also synthesized by the body under exposure to UV radiation. Vitamin D controls calcium and phosphorus metabolism and is responsible for bone modeling and mineralization. Objective. The objective of this study was to evaluate eating habits and food preferences of school-age children meet the demand for calcium and vitamin D, and estimate the frequency of consumption of foods rich in these nutrients. Material and methods. A total of 197 parents of 7- to 9-year-olds attending randomly selected primary schools in Lublin and Świdnik were asked to fill out a questionnaire designed by the authors. The results were processed by the Chi-squared test in the Excel application. Results. Considerable differences in the consumption of milk and dairy products were observed between age groups. In the group of 7-year-olds, 57.5% of children drank milk and ate dairy products at least once a day, whereas in the group of 9-year-olds, only 16.6% of children ate dairy products at least once a day. The intake of foods rich in vitamin D was equally low among the surveyed children. Conclusions. School-age children may be at risk of calcium and vitamin D deficiencies due to low consumption of milk, dairy products and fish, and inadequate vitamin D supplementation. Parents should be educated about nutrition to change the family’s eating habits.

13

Health outcomes of vitamin D. Part I. Characteristics and classic role

84%

Wranicz J., Szostak-Wegierek D.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 3

Vitamin D is a compound responsible for maintaining mineral homeostasis. It protects against calcium and phosphate deficiency through the effects on the intestine, kidney, parathyroid gland and bone. All mechanisms that help maintain mineral homeostasis of the body are regulated by the vitamin D hormonal form - calcitriol. Synthesis of vitamin D starts in the skin as a non-enzymatic process, which begins during exposure to sunlight, when the absorption of ultraviolet B (UVB) radiation results in convertion of 7-dehydrocholesterol, a metabolite of cholesterol that is stored in the skin, to precholecalciferol (previtamin-D3) that is immediately converted into cholecalciferol (vitamin D3). After the skin synthesis cholecalciferol is transported to the liver where it undergoes hydroxylation, what results in formation of calcidiol (25(OH) D3). The second metabolic process takes place in the kidney, where calcidiol undergoes hydroxylation at the C-1 position to the hormonal, the most active metabolite - 1,25-dihydroxyvitamin D (calcitriol). Vitamin D deficiency may result in bone diseases, such as rickets in children and osteomalacia and osteoporosis in adults. Symptoms of osteomalacia affect mainly the skeletal system and are similar to that observed in rickets. It concerns thoracic kyphosis, pelvis deformities and also the varus knee. Osteoporosis is another condition that is related to abnormalities of mineral homeostasis. It is characterized by the progressive loss of bone mass, impaired bone microarchitecture, and consequently increased fragility and susceptibility to fracture. For the last several years other, non-classic actions of vitamin D3 have been discussed. It was engendered by the discovery of vitamin D3 receptor (VDR) in the most of body tissues and cells. Hence, there are many hypotheses which suggest the inverse relationship between vitamin D status and various diseases, such as cancer, autoimmune diseases, diabetes mellitus and others.

14

Assessment of vitamin D status in children aged 1-5 with simple obesity

84%

Dylag H., Rowicka G., Strucinska M., Riahi A.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 4

Background. Proper vitamin D intake is important due to its pleiotropic effect. It seems that obese population is a groups at risk of the vitamin D deficiency. Objective. To assess the vitamin D status in 1-5-year-old children with simple obesity. Material and Methods. The study included 100 children: classified according to their body mass index (BMI) as obese – Group I (n=50) and non-obese – Group II (n=50). Their serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined in the spring-summer and autumn-winter seasons and vitamin D intake (diet/supplements) was assessed. The study results were statistically analysed by means of Statistica 10PL. Results. In Group I the mean serum 25(OH)D level was 23.6±10.8 ng/ml, while in Group II it reached 26.6±9.8 ng/ml (p=0.08). The concentration ≤30 ng/ml was observed in 80% of children in Group I and in 70% of Group II. In autumnwinter and spring-summer period, respectively, 88.5% and 70.9% of the obese children had an insufficient vitamin D status (p=0.002). The mean daily intake of vitamin D was 128 IU (3.2 μg) in Group I and 188 IU (4.7 μg) in Group II. Conclusions. Children aged 1-5 (obese and non-obese) are a group at risk of the vitamin D deficiency, as a consequence of its insufficient intake and the lack of appropriate supplementation. Those particularly exposed to that risk are obese children in the autumn-winter season. Children aged 1-5 should be monitored with regard to their vitamin D status.

15

Vitamin D and forearm bone mineral density in adolescent girls

84%

Wajszczyk B., Charzewska J., Chabros E., Rogalska-Niedzwiedz M., Chwojnowska Z., Fabiszewska J.

Polish Journal of Food and Nutrition Sciences

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2006

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tom 15/56

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nr Spec.Issue 2

The objective of the study was to evaluate the content of vitamin D in the diet and in blood serum of adolescent girls and the impact thereof on the forearm bone mineral density. Fifty eight girls aged 12-13 years from Warsaw have been examined. Data regarding the intake of vitamin D have been obtained during three 24-h recalls undertaken in one year. The concentration of vitamin D in blood serum has been determined three times in the perspective of one year. Two measurements have been taken in winter, one in the summer. The forearm bone mineral density (BMD) in the non-dominating arm has been examined using p-DXA osteoplan in the middistal and ultradistal section. The diets of the girls examined are characterised by a very low content of vitamin D. The percentage of that content against recommended norm has remained at the level of 20-25%. In both winter periods the sufficient level of vitamin D in blood serum has been observed only among 8.9% of the girls. In the middistal section in the group of non-menstruating girls BMD have been significantly higher, when the level of vitamin D in blood serum exceeded 50 nmol/L.

16

The level of vitamin D-binding protein (DBP) in serum of foals

67%

Madej J. P.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2008

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tom 11

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nr 4

17

Analysis of the dietary factors contributing to the future osteoporosis risk in young Polish women

67%

Sidor P., Glabska D., Wlodarek D.

Roczniki Państwowego Zakładu Higieny

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2016

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tom 67

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nr 3

Background. The osteoporosis is becoming serious problem for the preventive healthcare, that is stated for Poland and western countries. The loss of bone mass in women may be even five times higher than in men, so in the osteoporosis preventive strategies, young women are indicated as best potential target group. Objective. The aim of the study was to analyze the osteoporosis risk, on the basis of diet assessment in young Polish women, while satisfying nutritional needs for bone health-related nutrients was taken into account. Material and Methods. The study was conducted in the group of 75 women, aged 20-30, who prepared three-day dietary record (14% of underweight, 15% of excessive body mass individuals). The intakes of nutrients being associated directly with risk of osteoporosis (protein, potassium, calcium, magnesium, vitamin D, vitamin B6, folates, vitamin B12, vitamin C) were analysed. Results. The vast majority (89%) of individuals was characterized by lower declared energy intake than calculated requirement. The majority was characterized by inadequate intake of potassium, calcium, magnesium, vitamin D and folates. Only 25% was characterized by an adequate intake of calcium and, while supplementation was taken into account, 10% was characterized by an adequate intake of vitamin D. Conclusions. Following diets declared by the analysed young women may be the factor increasing seriously the risk of osteoporosis, as well as the risk of other diet-related diseases. The low intake of majority of analysed nutrients in the analysed group may result mainly from low energy value of declared diets. Taking into account the proper BMI of the majority of analysed group of young women and low energy value of their declared diets, the common underreporting may be supposed, and it may contribute to osteoporosis risk overestimation.

18

Celowość i możliwości wzbogacania produktów zbożowych w Polsce

67%

Bartnik J.

Roczniki Państwowego Zakładu Higieny

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1963

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tom 14

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nr 2

19

Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats

67%

Testerink J., Degens H., Rittweger J., Shiraishi A., Jaspers R. T., De Haan A.

Journal of Physiology and Pharmacology

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2011

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tom 62

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nr 1

Vitamin D deficiency is associated with muscle weakness. It is unknown, however, how supra-physiological levels of vitamin D affect skeletal muscle. To investigate the effects of increased serum vitamin D (1,25 (OH)2D3 or 1,25D) levels on the contractile properties of the medial gastrocnemius muscle, adult and old female Fischer344 x Brown Norway F1 rats were orally treated with vehicle or the vitamin D analogue alfacalcidol for 1 or 6 weeks. Alfacalcidol treatment resulted in elevated 1,25D serum levels. This was accompanied by hypercalcaemia and a reduction in body mass, the latter largely attributable to a reduced food intake. However, kidney function, as reflected by normal creatinine serum levels, as well as heart mass were unaffected. The 17% reduction in maximal isometric force and power was explicable by a similar loss of muscle mass. The force-frequency relationship of the 6-week-treated old rats was shifted to the left, but neither the shape of the force-velocity relationship nor the fatigability of the muscle were altered. Supra-physiological doses of vitamin D were accompanied by significant reductions in body and muscle mass, but not by an improvement in muscle functioning. Weight loss was largely due to a reduced food intake, while the left shift in the force-frequency relation may be due to increased 1,25D levels.

20

LL-37 but not 25-hydroxy-vitamin D serum level correlates with healing of venous leg ulcers

67%

Krejner A., Litwiniuk M., Grzela T.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 5

Ograniczanie wyników

The renaissance of vitamin D

Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells

Subtypes of the Gc gene (vitamin D binding protein) in the Polish population

Association analysis of vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves' disease

Dietary intake of vitamin D in obese children aged 1-3 years with simple obesity

Effect of administration of two forms of vitamin D in a feed mixture on the strength traits of the femur bone of broiler chickens

Serum soluble Klotho protein level is associated with residual diuresis in incident peritoneal dialysis patients

Decreased serum adiponectin reflects low vitamin D, high interleukin 6, and poor physical performance in knee osteoarthritis

Vitamin D and its relevance in the etiopathogenesis of oral cavity diseases

Wyniki zastosowania metody zapobiegawczej do oznaczania biologicznej aktywnosci witaminy D, na podstawie pomiarów szerokości chrząstki przynasadowej

Health outcomes of vitamin D. Part II. Role in prevention of diseases

Frequency of consumption of foods rich in calcium and vitamin D among school-age children