Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 32

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  uric acid
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Introduction. Elevated uric acid (UA) is associated with arterial hypertension (AH), obesity, dyslipidemia and insulin resistance. However, its association with body components has not been previously investigated. Objective. The aim of this study was to evaluate the relationship between UA and cardiovascular risk factors, anthropometric parameters and body composition in patients with AH. Materials and method. In 138 patients with AH the following parameters were evaluated: UA, low and high density lipoproteins (LDL-C, HDL-C), triglycerides (TG), fasting glucose (FG), creatinine; body mass index (BMI), waist circumference (WC), fat mass (FM), fat free mass (FFM) and total body water (TBW). Results. Positive correlations were shown between UA and LDL-C (p=0.041), TG (p<0.001), FG (p=0.025) and creatinine (p<0.001) and negative between UA and HDL-C (p<0.001). Significant associations between UA and anthropometric parameters and body components, such as WC (p<0.001), BMI (p<0.001), FFM (p<0.001) and TBW (p<0.001), were also observed. In the multiple regression model, independent predictors of UA concentration were serum creatinine and TBW (R2=0.45; p<0.001). Conclusions. In patients with AH, uric acid was significantly related to cardiovascular risk factors, including obesity. However, the main anthropometric determinant of plasma UA concentration is FFM. The consideration of body composition in the interpretation of UA concentration appears to be justified, but the verification of this hypothesis requires further studies.
Using High Performance Liquid Chromatography, concentrations of uric acid in the surface waters of two non-glaciated catchments (Fugle and Dynamisk) on Spitsbergen were measured. Measurements of specific conductivity enabled us to perform tests on the dissolution of the carbonate rocks present in both catchments in both natural and aqueous solutions of uric acid. Samples of calcium urate were made and its water solubility determined. Given a knowledge of concentrations of uric acid. calcium ions and calcium urate solubility product. an estimate of the role of uric acid in the dissolution of carbonate rocks was possible. Uric acid increases the dissolution of carbonate rocks by c. 12.5% in case of the Fugle catchment and 7% in Dynamisk.
In a group of 129 obese men and women asymptomatic hyperuricaemia was found in 49 and gout in 30 patients. Moderate positive correlation between serum uric acid level and body mass index was observed. Serum uric acid level was higher in all groups of obese patients than in the control group. The mean rate clearance was significantly decreased in obese patients with hyperuricaemia and gout. The most prevalent was the metabolic type of hyperuricaemia found in 58% of males and in 43% of females, followed by the mixed type (in 27% of males and in 29% of females). The renal type of hyperuricaemia was found in 15% of men and 28% of women. A significant increase in beta2-microglobulin in serum and urine of patients with hyperuricaemia and gout was determined by the radioimmunologic test. These results point to the incipient kidney lesions.
Pretreatment and analysis of urea and uric acid in body fluids and those of newly identified toxic compounds in dental material are described. Urea is a major uremic toxin. The accumulation of urea in blood may promote serious uremia syndrome if not regularly removed. Thus, an accurate analysis of blood urea is required for precise diagnosis. There have not been reported so far for differential analysis of free blood urea from bound urea as well as urea from endogenous ammonium. The author found the simplest differential method of urea and endogenous ammonium analysis in blood using a strong cation exchange resin column. For pretreatment of blood urea, solid phase extraction and dialysis were compared. The solid phase extraction method was found to be superior to dialysis in terms of recovery rate. Separation efficiency and reproducibility of blood urea determination using HPLC and MECC were also compared. Identification of newly toxic compounds in dental material, was carried out by LC-MS-MS and determination to saliva was by HPLC combined with SPE.
The profile and normal concentrations of nucleotide metabolites in human saliva and reproducibility of these determinations were analyzed. Samples of human saliva collected from healthy individuals at weekly intervals, were deproteinized and analysed for the content of adenine nucleotides and their metabolites by reversed-phase HPLC. Initial ATP, hypoxanthine and uric acid concentrations were 0.52 0.15 µM, 1.91 0.37 µM and 184 22 µM respectively. A substantial individual variation persisted within 3 weeks of sampling excepted hypoxanthine which showed some unrelated variations. Determination of nucleotides and their catabolites in saliva due to its simplicity and reproducibility, may be of clinical value in diagnosis of local or systemic disorders.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 2 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.