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1

Functional analysis of spermatocyte-specific hst70 gene promoter in transgenic mice

100%
Widlak W., Markkula M., Krawczyk Z., Huhtaniemi I.
Acta Biochimica Polonica
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1994
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tom 41
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nr 2
2

Effects of growth hormone on neuroendocrine function

100%
Bartke A., Chandrashekar V., Steger R. W.
Acta Neurobiologiae Experimentalis
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1996
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tom 56
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nr 3
3

Unexpected reaction of anti-H-2d serum with thymic lymphoma cells derived from transgenic B6-H-2b TCR anti-HY-Db mice

84%
Matuszyk J., Ziolo E., Kobzdej M., Strzadala L.
Archivum Immunologiae et Therapiae Experimentalis
|
1996
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tom 44
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nr 2-3
4

CD45 in memory and disease

84%
Tchilian E. Z., Beverley P. C. L.
Archivum Immunologiae et Therapiae Experimentalis
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2002
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tom 50
|
nr 2
5

Abnormal purine and pyrimidine nucleotide content in primary astroglia cultures from HGPRT - deficient transgenic mice

84%
Pelled D., Sperling O., Zoref-Shani E.
Cellular and Molecular Biology Letters
|
1999
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tom 04
|
nr 3
6
Content available remote

Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice

84%
Plaas M., Karis A., Innos J., Rebane E., Baekelandt V., Vaarmann A., Luuk H., Vasar E., Koks S.
Journal of Physiology and Pharmacology
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2008
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tom 59
|
nr 2
Lewy bodies are mainly composed of alpha-synuclein (SNCA) and specific mutations in SNCA gene are related to familial forms of Parkinson's disease (PD). The purpose of our study was to generate a mouse line with A30P knock-in point mutation in SNCA gene and to test if a single point-mutation is able to turn otherwise normal SNCA into a toxic form. The behavioral profile of SNCA A30P mice was followed for 16 months. Generally, these mice are healthy and viable without any obvious abnormalities. Starting from the age of 13 months mice developed a significant deficit in motor performance tests related to nigrostriatal function (ink-test and beam walk). In other tests (motility boxes, rotarod) mice continuously performed normally. Moreover, SNCA A30P mice expressed the altered sensitivity to VMAT2 inhibitor reserpine, possibly reflecting a functional deficiency of dopamine. Indeed, mice at 15 months of age had significantly reduced levels of dopamine and its major metabolite DOPAC in the striatum, and reduced levels of dopamine in the mesolimbic system. The present study confirms that SNCA plays an important role in the development of PD and an insertion of a single point mutation is sufficient to generate age-related decline in specific motor performance. The generated mouse line has a potential to become a model for PD with comparable time course and phenotype.
7

Autoimmunity caused by T cells escaping negative selection

67%
Rolink A.
Archivum Immunologiae et Therapiae Experimentalis
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2011
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tom 59
|
nr 5
8

Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1

67%
Piotrowska K., Sluczanowska-Glabowska S., Kucia M., Bartke A., Laszczynska M., Ratajczak M. Z.
Folia Histochemica et Cytobiologica
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2015
|
tom 53
|
nr 3
9
Content available remote

Comparison of acetaminophen toxicity in primary hepatocytes isolated from transgenic mice with different apolipoprotein E alleles

67%
Mezera V., Kucera O., Moravcova A., Peterova E., Rousar T., Rychtrmoc D., Sobotka O., Cervinkova Z.
Journal of Physiology and Pharmacology
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2015
|
tom 66
|
nr 6
10

Human antibody expression in transgenic mice

67%
Bruggemann M.
Archivum Immunologiae et Therapiae Experimentalis
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2001
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tom 49
|
nr 3
203-208
11

Loss of T cell receptor diminished tumorigenicity of thymocyte-derived lymphoma cells in the T cell receptor transgenic mice

67%
Kobzdej M., Matuszyk J., Ziolo E., Strzadala L.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
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nr 4
12

DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response

67%
Cao W., Hunter R., Strnatka D., McQueen C. A., Erickson R. P.
Journal of Applied Genetics
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2005
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tom 46
|
nr 2
Arylamine N-acetyltransferase (NAT) genes were targeted for inhibition using short hairpin RNA (shRNA) using two different RNA polymerase III promoters. Constructs were developed for NAT1 and NAT2, the endogenous mouse genes, and for human NAT1. There were fetal and neonatal deaths with these constructs, perhaps due in part to an interferon response as reflected in increases in oligoadenylate synthetase I mRNA levels. Seven out of 8 founders with the U6 promoter generated offspring but only 2 gave positive offspring. Out of 15 founders for H1 promoted constructs, only 4 had positive offspring. When transgenic lines were successfully established, the expression of the targeted genes was variable between animals and was not generally inhibitory.
13

From embryonic stem cells and induced pluripotent cells to lymphocytes

59%
Seiler K., Tornack J., Karjalainen K., Tsuneto M., Melchers F.
Archivum Immunologiae et Therapiae Experimentalis
|
2011
|
tom 59
|
nr 5
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