Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: synthetic analogue

Sortuj według:

Ogranicz wyniki do:

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors

100%

Benyhe Z., Toth G., Wollemann M., Borsodi A., Helyes Z., Rougeot C., Benyhe S.

Journal of Physiology and Pharmacology

2014

tom 65

nr 4

Effect of synthetic GnRH analogues on ovarian follicular growth dynamic and oestrus

80%

Masiulis M., Zilinskas H., Rutkauskas A., Riskeviciene V.

Medycyna Weterynaryjna

2007

tom 63

nr 08

922-925

The aim of the present study was to evaluate the stimulating effect of synthetic GnRH analogues without the use of prostaglandins on ovarian follicular growth dynamic and oestrus. The study was made on 30, 3 to 9-year-old Lithuanian Black and White (LBW) and German Black and White (GBW) breed cows. The study was conducted in the Lithuanian Veterinary Academy practical training and research farm. Oestrus in 23 cows was stimulated using synthetic GnRH analogues Dalmarelin (Lecirelin) (Fatro S. p. A., Italy) and in 14 cows with the use of Depherelin® (Gonavet® 50, Veyx-Pharma GmbH, Germany). Dalmarelin (Lecirelin) induced oestrus in 100% of the stimulated cows, and Depherelin® (Gonavet® 50) induced oestrus in 92.9 % of stimulated cows. Following an injection of synthetic GnRH analogues, preparations Depherelin® and Dalmarelin, plasma progesterone concentration decreased, due to the ovulation of dominant follicle or onset of the new follicular wave. Cows stimulated with Dalmarelin had a faster follicular growth rate and bigger size of follicles at ovulation compared to Depherelin® and control group cows (p = 0.05). In the pregnancy trial that followed 45 days after artificial insemination, the highest percentage (43.5 %) of pregnant cows was determined in the group of cows stimulated with Dalmarelin.

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells

80%

Marcinkowska E., Kutner A.

Acta Biochimica Polonica

2002

tom 49

nr 2

Synthetic analogs of vitamin D for potential use in differentiation therapy should selectively regulate genes necessary for differentiation without inducing any perturbations in calcium homeostasis. PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have higher differentiation-inducing activity as estimated in HL-60 leukemia cell model. To examine how their increased differentiation-inducing activity is regulated we tested the hypothesis that membrane-mediated events, unrelated to nVDR, take part in the differentiation in response to PRI-1906 and PRI-2191. The induction of leukemia cell differentiation in response to the analogs of vitamin D was inhibited by LY294002 (phosphatidyl- inositol 3-kinase inhibitor), PD98059 (inhibitor of MEK1,2, an upstream regulator of extracellular-signal regulated kinase) and rapamycin (p70 S6K inhibitor) pointing out that activation of signal transduction pathways unrelated to nVDR is necessary for differentiation. On the other hand, inhibition of cytosolic phospholipase A2 accelerated the differentiation of HL-60 cells induced by either 1,25-D3 or by the vitamin D analogs suggesting possible existence of a feedback loop between extracellular-signal regulated kinases and phospholipase A2.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Journal of Physiology and Pharmacology

1 Medycyna Weterynaryjna

1 Benyhe S.

1 Benyhe Z.

1 Borsodi A.

1 Helyes Z.

1 Kutner A.

1 Marcinkowska E.

1 Masiulis M.

1 Riskeviciene V.

1 Rougeot C.

1 Rutkauskas A.

1 Toth G.

1 Wollemann M.

1 Zilinskas H.

1 2014

1 2007

1 2002

Wyniki wyszukiwania

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors

Effect of synthetic GnRH analogues on ovarian follicular growth dynamic and oestrus

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells