Wyniki wyszukiwania

1

Peroxisome proliferator-activated receptor gamma [PPARgamma] and sepsis

100%

Von Knethen A., Soller M., Brune B.

Archivum Immunologiae et Therapiae Experimentalis

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2007

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tom 55

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nr 1

2

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The effect of omeprazole on treatment outcomes in patients with severe traumatic brain injury and sepsis

86%

Oliynyk O.

Health Problems of Civilization

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2021

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tom 15

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nr 2

Background. The interrelation between omeprazole use and the possibility of developing nosocomial pneumonia, acute kidney damage and Clostridium difficile-induced diarrhea in patients with sepsis requires further study. Material and methods. 200 patients with severe craniocerebral injury that underwent surgery for the pathology and developed sepsis in the postoperative period were examined in a blind, randomized placebo-controlled research study. The patients were divided into two groups. Patients in Group 1, as part of their therapy regimen for sepsis, received a daily dose of 0.2 mg/kg omeprazole as an intravenous infusion; patients in Group 2 received placebo instead of omeprazole, in addition to a similar therapy regimen as Group 1. Results. Among patients receiving omeprazole, the number of concomitant ventilatorassociated pneumonia cases increased by 1.32 times, the number of acute kidney damage cases by 1.33 times and the number of cases of Clostridium difficile toxin secretion with feces by 1.75 times. Conclusions. The routine use of omeprazole in the management of patients with sepsis may worsen treatment results.

3

Therapeutic approach to a child with acute respiratory distress syndrome: a report of two cases

86%

Nosal S., Durdik P., Luptakova A., Sutovska M., Nosal V., Jesenak M., Havlicekova Z., Hamzik J., Banovcin P.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

43-51

4

Hypothermia effects on liver and kidney oxidative stress parameters in an experimental model of sepsis in rats

86%

Sidonia B., Horatiu R., Vlad L., Francisc D., Ciprian O., Cosmin P., Liviu O., Sanda A.

Journal of Veterinary Research

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2020

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tom 64

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nr 1

5

Staphylococcal superantigens: do they play a role in sepsis?

86%

Holtfreter S., Broker B. M.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

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nr 1

6

Soluble selectin profiles associated with severe trauma

86%

Siemiatkowski A., Rogowski F., Wereszczynska-Siemiatkowska U., Malinowska L., Borkowski J.

Archivum Immunologiae et Therapiae Experimentalis

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2001

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tom 49

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nr 4

7

Immune balance in critically ill patients

72%

Pinsky M. R.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

|

nr 6 Spec.Iss.

439-442

8

Immunotherapy of sepsis: blind alley or call for personalized assessment?

72%

Prucha M., Zazula R., Russwurm S.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 1

9

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

72%

Kowalczyk A., Kleniewska P., Kolodziejczyk M., Skibska B., Goraca A.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 1

10

The therapeutic potential of interleukin 10 in infection and inflammation

72%

Kumar A., Creery W. D.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

|

nr 6 Spec.Iss.

529-538

11

Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study

72%

Hoser G. A., Skirecki T., Zlotorowicz M., Zielinska-Borkowska U., Kawiak J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

|

nr 3

12

Functional analysis of eicosanoids from white blood cells in sepsis and SIRS

72%

Baenkler M., Leykauf M., John S.

Journal of Physiology and Pharmacology. Supplement

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2006

|

tom 57

|

nr 12

25-33

Sepsis and SIRS are affections with major alterations in inflammatory activity. The impact of prostaglandins (PG) and leukotrienes (LT) produced from white blood cells (WBC) in this context is not completely understood. Thirty nine patients with sepsis or SIRS were investigated in comparison to 10 healthy controls. WBC were collected and separately exposed to arachidonic acid (AA) or to nothing else. After centrifugation, the generated PGE2 and LTCDE4 with or without stimulation were measured in the supernatant. LT-levels were significantly higher during sepsis/SIRS than in controls whereas PG-levels of patients were decreased to those of controls in basic condition. The relation between the level with and without stimulation showed a significant higher ratio in PG in contrast to LTs. The survivor’s ratio in LT levels was significantly higher than that of non-survivors, which did not differ from controls. Generation of LT from WBC is enhanced during sepsis/SIRS, but LT generation after stimulation only in survivors but not in non-survivors. This inability of WBC to generate LT during sepsis in non-survivors could be predictive regarding the outcome of sepsis/SIRS and may be part of the “immunoparalysis” seen during sepsis in association with bad outcome.

13

MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1

72%

Meng L., Cao H., Wan C., Jiang L.

Folia Histochemica et Cytobiologica

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2019

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tom 57

|

nr 4

14

Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock

72%

Jedynak M., Siemiatkowski A., Mroczko B., Groblewska M., Milewski R., Szmitkowski M.

Archivum Immunologiae et Therapiae Experimentalis

|

2018

|

tom 66

|

nr 4

15

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans

72%

Reiter R. J., Tan D., Mayo J. C., Sainz R. M., Leon J., Czarnocki Z.

Acta Biochimica Polonica

|

2003

|

tom 50

|

nr 4

This brief resume enumerates the multiple actions of melatonin as an antioxidant. This indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other organs. Additionally, however, it is found in invertebrates, bacteria, unicellular organisms as well as in plants, all of which do not have a pineal gland. Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiency of other antioxidants. There may be other functions of melatonin, yet undiscovered, which enhance its ability to protect against molecular damage by oxygen and nitrogen-based toxic reac- tants. Numerous in vitro and in vivo studies have documented the ability of both physiological and pharmacological concentrations to melatonin to protect against free radical destruction. Furthermore, clinical tests utilizing melatonin have proven highly successful; because of the positive outcomes of these studies, melatonin's use in disease states and processes where free radical damage is involved should be increased.

16

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels septic patients

72%

Piechota M., Banach M., Irzmanski R., Misztal M., Rysz J., Barylski M., Piechota-Urbanska M., Kowalski J., Pawlicki L.

Cellular and Molecular Biology Letters

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2007

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tom 12

|

nr 2

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

17

Studies on the effects of lipopolysaccharide on lipid peroxidation of erythrocyte and its reversal by mannitol and glycerol

72%

Bhattacharyya J., Datta A. G.

Journal of Physiology and Pharmacology

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2001

|

tom 52

|

nr 1

18

Exposition of newborn rats to bacterial endotoxin impairs pancreatic enzyme secretion at adult age

72%

Jaworek J., Nawrot-Porabka K., Leja-Szpak A., Szklarczyk J., Macko M., Bonior J., Stachura J., Konturek S. J., Pawlik W. W.

Journal of Physiology and Pharmacology

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2007

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tom 58

|

nr 2

Lipopolysaccharide (LPS, endotoxin) is the component of the cellular wall of Gram negative bacteria. Endotoxemia (sepsis) could produce multiorgan failure and in the early period of life LPS are responsible for the changes of metabolism and for the reduction of protein synthesis. The influence of neonatal endotoxemia on the pancreas at adults has not been investigated yet. The aim of this study was to assess the pancreatic exocrine function in the adult rats which have been subjected, in the neonatal period of life, to chronic LPS pretreatment. LPS from E. coli or S. typhi at doses of 5, 10 or 15 mg/kg-day was administered intraperitoneally (i.p.) to the suckling rats (30 g) during 5 consecutive days. Three months later these animals (300 g) were equipped with pancreato-biliary fistulae for the in vivo secretory study. Amylase release from isolated pancreatic acini obtained from these rats was also assessed. Pancreatic tissue samples were taken for histological assessment and for the determination of gene expression for CCK1 receptor by RT-PCR. Pancreatic amylase secretions stimulated by caerulein or by diversion of pancreatic-biliary juice to the exterior (DBPJ) was significantly, and dose-dependently reduced in the adult rats which have been subjected in infancy to chronic pretreatment with LPS from E. coli or S. typhi, as compared to the untreated control. In these animals basal secretion was unaffected. In the rats pretreated with LPS in the suckling period of life caerulein-induced amylase release from isolated pancreatic acini was significantly decreased, as compared to the untreated with LPS control. This was accompanied by dose-dependent reduction of mRNA signal for CCK1 receptor on pancreatic acini. Neonatal endotoxemia failed to affect significantly pancreatic morphology as well as plasma amylase level in the adult rats. We conclude that neonatal endotoxemia reduces gene expression for CCK1 receptor and could produce impairment of the exocrine pancreatic function at adult age.

19

Immunological status of septic and trauma patients. I. High tumor necrosis factor alpha serum levels in septic and trauma patients are not responsible for increased mortality; a prognostic value of serum interleukin 6

72%

Adamik B., Zimecki M., Wlaszczyk A., Kubler A.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

|

nr 2-3

20

Stroke, myocardial infarction, acute and chronic inflammatory diseases: caspase and other apoptotic molecules as targets for drug development

72%

Kreuter M., Langer C., Kerkhoff C., Reddanna P., Kania A. L., Maddika S., Chlichlia K., Bui T. N., Los M.

Archivum Immunologiae et Therapiae Experimentalis

|

2004

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tom 52

|

nr 3

Ograniczanie wyników

Peroxisome proliferator-activated receptor gamma [PPARgamma] and sepsis

The effect of omeprazole on treatment outcomes in patients with severe traumatic brain injury and sepsis

Therapeutic approach to a child with acute respiratory distress syndrome: a report of two cases

Hypothermia effects on liver and kidney oxidative stress parameters in an experimental model of sepsis in rats

Staphylococcal superantigens: do they play a role in sepsis?

Soluble selectin profiles associated with severe trauma

Immune balance in critically ill patients

Immunotherapy of sepsis: blind alley or call for personalized assessment?

The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis

The therapeutic potential of interleukin 10 in infection and inflammation

Absolute counts of peripheral blood leukocyte subpopulations in intraabdominal sepsis and pneumonia-derived sepsis: a pilot study

Functional analysis of eicosanoids from white blood cells in sepsis and SIRS

MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1

Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock

Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans