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Effect of calf thymus extract and zinc supplementation on the cellular response of mice exposed to restraint stress

100%

Obminska-Mrukowicz B., Szczypka M.

Polish Journal of Veterinary Sciences

2005

tom 08

nr 1

Modulatory effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field

100%

Klenerova V., Krejci I., Sida P., Hlinak Z., Hynie S.

Journal of Physiology and Pharmacology

2009

tom 60

nr 2

57-62

Oxytocin (OXY) has been shown to attenuate some of the physiological and behavioral alterations appearing in stressed rats. Carbetocin (CBT), an oxytocin analog [deamino-1-monocarba-(2-O-methyltyrosine)-oxytocin], was designed to exert prolonged action. In the present study we investigated the impact of these peptides on the behavioral changes in rats exposed repeatedly to restraint stressors. Wistar male rats were exposed to restraint for 1 hour; saline or drugs were administered intraperitoneally immediately after stress termination. Recording of the exploratory activity in the open-field started 60 min later. To explore the possibility of persisting effects of stress and/or drugs, the procedure was repeated for three consecutive days. Restraint moderately suppressed locomotion and rearing, and increased grooming. OXY in 0.3 mg/kg dose showed a tendency to restore the suppressed exploratory activity. In contrast, 1 mg/kg dose potentiated the stress-induced behavioral deficit. Both OXY doses slightly increased grooming. CBT in the same two doses restored the stress-induced deficits in locomotion and rearing but did not influence grooming. The locomotor depression after 1 mg dose of OXY was found also in non-stressed rats in contrast to the increased activity after CBT. The data support the view that post-stress administered CBT exerts a significant effect on the stress-altered spontaneous behavior.

Prefrontal catecholaminergic turnover and antioxidant defense system of chronically stressed rats

100%

Popovic N., Pajovic S. B., Stojiljkovic V., Pejic S., Todorovic A., Pavlovic I., Gavrilovic L.

Folia Biologica

2017

tom 65

nr 1

Ograniczanie wyników

1 Folia Biologica

1 Journal of Physiology and Pharmacology

1 Polish Journal of Veterinary Sciences

1 Gavrilovic L.

1 Hlinak Z.

1 Hynie S.

1 Klenerova V.

1 Krejci I.

1 Obminska-Mrukowicz B.

1 Pajovic S. B.

1 Pavlovic I.

1 Pejic S.

1 Popovic N.

1 Sida P.

1 Stojiljkovic V.

1 Szczypka M.

1 Todorovic A.

1 2017

1 2009

1 2005

Wyniki wyszukiwania

Effect of calf thymus extract and zinc supplementation on the cellular response of mice exposed to restraint stress

Modulatory effects of oxytocin and carbetocin on stress-induced changes in rat behavior in the open-field

Prefrontal catecholaminergic turnover and antioxidant defense system of chronically stressed rats